Intrahepatische Schwangerschaftscholestase

Zusammenfassung

Die intrahepatische Schwangerschaftscholestase (ICP) ist eine seltene, aber potenziell schwerwiegende Schwangerschaftskomplikation, deren Leitsymptom ein die schwangere Frau quälender Pruritus bei erhöhten Serumspiegeln der Gallensäuren ist. Erhöhte Serumkonzentration gilt als Prädiktor für ein schlechtes perinatales Outcome bis hin zum intrauterinen Tod. Als Therapie der Wahl hat sich Ursodesoxycholsäure (UDCA) zur signifikanten Symptomverbesserung und Verminderung der Cholestase in der klinischen Versorgung etabliert. Die engmaschige Überwachung und Behandlung von Schwangeren mit einer schweren intrahepatischen Cholestase sollte immer in einem Perinatalzentrum interdisziplinär durch Perinatologen und Hepatologen erfolgen, damit neben den maternalen Beschwerden die wesentlich erhöhte perinatale Morbidität und Mortalität minimiert werden.

Schlüsselwörter

Schwangerschaftscholestase - Pruritus - Gallensäuren - Schwangerschaftsvorsorge - Geburtseinleitung - Fruchttod

Publikationsverlauf

Eingereicht: 19. Juni 2020

Angenommen nach Revision: 02. Juni 2021

Artikel online veröffentlicht:
09. August 2021

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