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Planta Med 2021; 87(10/11): 850-859
DOI: 10.1055/a-1519-5847
Biological and Pharmacological Activity
Original Papers

Malaria in Guinean Rural Areas: Prevalence, Management, and Ethnotherapeutic Investigations in Dionfo, Sub-Prefecture of Labe[ # ]

Aliou Mamadou Baldé
1   Institut de Recherche et de Développement des Plantes Médicinales et Alimentaires de Guinée, Dubréka, BP 6411 Conakry, Guinée
2   Faculté des Sciences et Techniques de la Santé, Université Gamal Abdel Nasser de Conakry, Guinée
,
Alpha Oumar Balde
2   Faculté des Sciences et Techniques de la Santé, Université Gamal Abdel Nasser de Conakry, Guinée
,
Bilo Bah
2   Faculté des Sciences et Techniques de la Santé, Université Gamal Abdel Nasser de Conakry, Guinée
,
Halimatou Barry
2   Faculté des Sciences et Techniques de la Santé, Université Gamal Abdel Nasser de Conakry, Guinée
,
Saidou Traore
1   Institut de Recherche et de Développement des Plantes Médicinales et Alimentaires de Guinée, Dubréka, BP 6411 Conakry, Guinée
,
Fatoumata Bah
3   Faculté des Sciences, Université Julius Nyéréré de Kankan
,
Mamadou Aliou Balde
2   Faculté des Sciences et Techniques de la Santé, Université Gamal Abdel Nasser de Conakry, Guinée
,
Aissata Camara
2   Faculté des Sciences et Techniques de la Santé, Université Gamal Abdel Nasser de Conakry, Guinée
,
Mohamed Sahar Traore
1   Institut de Recherche et de Développement des Plantes Médicinales et Alimentaires de Guinée, Dubréka, BP 6411 Conakry, Guinée
2   Faculté des Sciences et Techniques de la Santé, Université Gamal Abdel Nasser de Conakry, Guinée
,
Elhadj Saidou Balde
1   Institut de Recherche et de Développement des Plantes Médicinales et Alimentaires de Guinée, Dubréka, BP 6411 Conakry, Guinée
2   Faculté des Sciences et Techniques de la Santé, Université Gamal Abdel Nasser de Conakry, Guinée
,
Ibrahima Kalil Sylla
1   Institut de Recherche et de Développement des Plantes Médicinales et Alimentaires de Guinée, Dubréka, BP 6411 Conakry, Guinée
,
Sadou Diallo
4   Tradithérapeute professionnel, Dionfo-Centre, Labé, Guinée
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Abstract

As part of a validation program of antimalarial traditional recipes, an ethnotherapeutic approach was applied in Dionfo, a meso-endemic Guinean rural area where conventional health facilities are insufficient. A prevalence investigation indicated a malarial burden of 4.26%. Ethnomedical and ethnobotanical surveys led to a collection of 63 plant species used against malaria from which Terminalia albida (Combretaceae) was one of the most cited. Ethnotherapeutic evaluation of a remedy based on T. albida was applied to 9 voluntary patients suffering from uncomplicated malaria. Treatment of 7 to 14 days led to an improvement of clinical symptoms and a complete parasite clearance achievement of 8/9 patients without side effects. In addition to antiplasmodial activity in vitro and in vivo previously described, this study indicates an efficacy to support the antimalarial traditional use of T. albida, which could constitute a first-aid treatment when access to other medicines is delayed in the Dionfo community. Ethnotherapeutical investigation could be a valuable approach to guide subsequent investigations on traditional remedies.

Key words

malaria - Guinea - rural areas - ethnotherapeutic - Terminalia albida

# Dedicated to Professor Arnold Vlietinck on the occasion of his 80th birthday.




Publication History

Received: 30 January 2021

Accepted after revision: 30 May 2021

Article published online:
06 July 2021

© 2021. Thieme. All rights reserved.

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