Sodium Aminodiboranate, a New Reagent for Chemoselective Reduction of Aldehydes and Ketones to Alcohols

Jin Wang; Yu Guo; Shouhu Li; Xuenian Chen

doi:10.1055/a-1479-5008

Synlett, Table of Contents

Synlett 2021; 32(11): 1104-1108
DOI: 10.1055/a-1479-5008

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Sodium Aminodiboranate, a New Reagent for Chemoselective Reduction of Aldehydes and Ketones to Alcohols

Jin Wang

^aSchool of Chemistry and Chemical Engineering, Henan Key Laboratory of Boron Chemistry and Advanced Energy Materials, Henan Normal University, Xinxiang, Henan 453007, P. R. of China

^bCollege of Chemistry and Chemical Engineering, Mudanjiang Normal University, Mudanjiang 157011, P. R. of China

,

Yu Guo

^aSchool of Chemistry and Chemical Engineering, Henan Key Laboratory of Boron Chemistry and Advanced Energy Materials, Henan Normal University, Xinxiang, Henan 453007, P. R. of China

,

Shouhu Li

^aSchool of Chemistry and Chemical Engineering, Henan Key Laboratory of Boron Chemistry and Advanced Energy Materials, Henan Normal University, Xinxiang, Henan 453007, P. R. of China

,

Xuenian Chen∗

^aSchool of Chemistry and Chemical Engineering, Henan Key Laboratory of Boron Chemistry and Advanced Energy Materials, Henan Normal University, Xinxiang, Henan 453007, P. R. of China

^cGreen Catalysis Center and College of Chemistry, Zhengzhou University, Zhengzhou 450001, P. R. of China

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Abstract

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Abstract

Sodium aminodiboranate (NaNH₂(BH₃)₂, NaADBH) is a new member of the old borane family, which exhibits superior performance in chemoselective reduction. Experimental results show that NaADBH can rapidly reduce aldehydes and ketones to the corresponding alcohols in high efficiency and selectivity under mild conditions. There are little steric and electronic effects on this reduction.

Key words

sodium aminodiboranate - hydrogenation - reduction - aldehydes - ketones

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References

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