Exp Clin Endocrinol Diabetes
DOI: 10.1055/a-1474-8193
Review

The Effect of Prandial Insulin Applied for Fat Protein Units on Postprandial Glucose Excursions in Type 1 Diabetes Patients with Insulin Pump Therapy: Results of a Randomized, Controlled, Cross-Over Study

Thomas Haak
1  Diabetes Clinic, Bad Mergentheim, Gemany
2  FIDAM – Research Institute Diabetes Academy, Mergentheim, Gemany
,
Ekaterina Herrmann*
1  Diabetes Clinic, Bad Mergentheim, Gemany
,
Bernhard Lippmann-Grob
1  Diabetes Clinic, Bad Mergentheim, Gemany
2  FIDAM – Research Institute Diabetes Academy, Mergentheim, Gemany
,
Astrid Tombek
1  Diabetes Clinic, Bad Mergentheim, Gemany
,
Norbert Hermanns
1  Diabetes Clinic, Bad Mergentheim, Gemany
2  FIDAM – Research Institute Diabetes Academy, Mergentheim, Gemany
,
Michael Krichbaum
2  FIDAM – Research Institute Diabetes Academy, Mergentheim, Gemany
› Author Affiliations

Abstract

Objective This randomized cross-over study aimed to compare different algorithms for calculating prandial insulin considering the fat and protein content of a standardized meal in type 1 diabetes patients using insulin pump therapy (CSII).

Methods Twenty-six patients received a standardized evening meal for three consecutive days using different algorithms for insulin dose adjustment: A) exclusive consideration of carbohydrate content without considering fat-protein content, B) high-dose algorithm considering additional insulin for fat protein units (FPUs) with the same factor as for carbohydrates, and C) low-dose algorithm considering additional insulin for FPUs with half the factor as for carbohydrates. The primary outcome was the proportion of interstitial glucose values in the target range (≥ 70 to ≤ 180 mg/dl) during the post-prandial 12-hour follow-up period. Secondary outcomes were the occurrence of hypo- and hyperglycemic episodes and the coverage with carbohydrates for treatment of hypoglycemia.

Results The percentage of glucose values in the target range was significantly higher when fat-protein content was not considered, whereas, in the hyperglycemic range, it did not differ significantly among the three groups. The percentage of hypoglycemic glucose values were the highest in the groups considering fat-protein content and lowest in the group not considering FPUs with no significant difference between the two groups in terms of FPUs.

Conclusions In adult type 1 diabetes patients using CSII, it is not recommended to consider a high fat and protein content in the diet when calculating prandial insulin dosage with the selected algorithms, as this increases the risk of hypoglycemia disproportionately.

* E. Herrmann actually is affiliated with Medicover Oldenburg MVZ.




Publication History

Received: 16 September 2020
Received: 13 March 2021

Accepted: 17 March 2021

Publication Date:
20 April 2021 (online)

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