CC BY-NC-ND 4.0 · Geburtshilfe Frauenheilkd 2021; 81(05): 539-548
DOI: 10.1055/a-1464-1221
GebFra Science
Review/Übersicht

Update Mammakarzinom 2021 Teil 2 – fortgeschrittene Stadien, Langzeitfolgen und Biomarker

Article in several languages: English | deutsch
Nina Ditsch
1   Department of Gynecology and Obstetrics, University Hospital Augsburg, Augsburg, Germany
,
Elmar Stickeler
2   Department of Gynecology and Obstetrics, RWTH University Hospital Aachen, Aachen, Germany
,
Annika Behrens
3   Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany
,
Erik Belleville
4   ClinSol GmbH & Co. KG, Würzburg, Germany
,
Peter A. Fasching
3   Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany
,
Tanja N. Fehm
5   Department of Gynecology and Obstetrics, University Hospital Düsseldorf, Düsseldorf, Germany
,
Andreas D. Hartkopf
6   Department of Obstetrics and Gynecology, University of Tübingen, Tübingen, Germany
,
Christian Jackisch
7   Department of Obstetrics and Gynecology, Sana Klinikum Offenbach, Offenbach, Germany
,
Wolfgang Janni
8   Department of Gynecology and Obstetrics, Ulm University Hospital, Ulm, Germany
,
Cornelia Kolberg-Liedtke
9   Department of Gynecology and Obstetrics, University Hospital Essen, Essen, Germany
,
Hans-Christian Kolberg
10   Department of Gynecology and Obstetrics, Marienhospital Bottrop, Bottrop, Germany
,
Diana Lüftner
11   Charité University Hospital, Department of Hematology, Oncology and Tumour Immunology, University Medicine Berlin, Berlin, Germany
,
Michael P. Lux
12   Klinik für Gynäkologie und Geburtshilfe, Frauenklinik St. Louise, Paderborn, St. Josefs-Krankenhaus, Salzkotten, St. Vincenz Krankenhaus GmbH, Paderborn, Germany
,
Volkmar Müller
13   Department of Gynecology, Hamburg-Eppendorf University Medical Center, Hamburg, Germany
,
Andreas Schneeweiss
14   National Center for Tumor Diseases (NCT), Heidelberg University Hospital and German Cancer Research Center, Heidelberg, Germany
,
Florian Schütz
15   Gynäkologie und Geburtshilfe, Diakonissen-Stiftungs-Krankenhaus Speyer, Speyer, Germany
,
Carla E. Schulmeyer
3   Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany
,
Hans Tesch
16   Oncology Practice at Bethanien Hospital Frankfurt, Frankfurt, Germany
,
Christoph Thomssen
17   Department of Gynaecology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany
,
Christoph Uleer
18   Praxisgemeinschaft Frauenärzte am Bahnhofsplatz, Hildesheim, Germany
,
Michael Untch
19   Clinic for Gynecology and Obstetrics, Breast Cancer Center, Genecologic Oncology Center, Helios Klinikum Berlin Buch, Berlin, Germany
,
Manfred Welslau
20   Onkologie Aschaffenburg, Aschaffenburg, Germany
,
Achim Wöckel
21   Department of Gynecology and Obstetrics, University Hospital Würzburg, Würzburg, Germany
,
Lena A. Wurmthaler
3   Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany
,
Rachel Würstlein
22   Breast Center, Department of Gynecology and Obstetrics and CCC Munich Ludwig Maximilians University, LMU University Hospital, Munich, Germany
,
Marc Thill
23   Agaplesion Markus Krankenhaus, Department of Gynecology and Gynecological Oncology, Frankfurt, Germany
,
Bahriye Aktas
24   Klinik und Poliklinik für Gynäkologie, Universitätsklinikum Leipzig, Leipzig, Germany
› Author Affiliations

Zusammenfassung

In dieser Übersichtsarbeit werden relevante Aspekte kürzlich veröffentlichter Studien zur Behandlung von Brustkrebspatientinnen in fortgeschrittenen Stadien sowie zu Biomarkern beim Mammakarzinom zusammenfassend dargestellt und diskutiert. In den letzten Jahren wurde eine Vielzahl von Medikamenten für alle molekularen Subtypen bis zu Phase-III-Studien entwickelt. In Bezug auf die Immuncheckpoint-Inhibitoren wurde in letzter Zeit für die metastasierte Situation der optimale Chemotherapie-Kombinationspartner diskutiert. Mit oralen Taxanen könnte sich eine neue Art von oralen Chemotherapien etablieren. Die Datenlage zu Biomarkern für die Anwendung der CDK4/6-Inhibitoren wächst, was auch eine Weiterentwicklung für andere molekulare Subtypen bedeuten könnte. Beim HER2+, metastasierten Mammakarzinom wurden neue Substanzen entwickelt, die auch nach massiver Vorbehandlung und/oder zerebraler Metastasierung noch gute Remissionen zeigen. Ebenso wächst das Wissen um zielgerichtete Therapien mit Antikörper-Wirkstoff-Konjugaten (ADC) gegen Trop-2, die bei triple-negativen Mammakarzinomen (TNBC) eine therapeutische Bereicherung bedeuten könnten. Des Weiteren steht das Verständnis des Fertilitätserhaltes nach einer Brustkrebserkrankung im klinischen Fokus. Hier schaffen gepoolte Analysen einen neuen Einblick.



Publication History

Received: 17 March 2021

Accepted after revision: 23 March 2021

Article published online:
03 May 2021

© 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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