Horm Metab Res 2021; 53(05): 341-349
DOI: 10.1055/a-1422-3243
Endocrine Care

Differential Effects of Various Androgens on Polycystic Ovary Syndrome

Sebastião Freitas de Medeiros
1  Department of Gynecology and Obstetrics, Medical School, Federal University of Mato Grosso, Cuiabá, MT, Brazil
2  Tropical Institute of Reproductive Medicine, Cuiabá, MT, Brazil
,
Bruna Barcelo Barbosa
2  Tropical Institute of Reproductive Medicine, Cuiabá, MT, Brazil
,
Ana Karine Lin Winck Yamamoto de Medeiros
2  Tropical Institute of Reproductive Medicine, Cuiabá, MT, Brazil
3  University of Cuiabá, MT, Brazil
,
Matheus Antônio Souto de Medeiros
2  Tropical Institute of Reproductive Medicine, Cuiabá, MT, Brazil
,
Márcia Marly Winck Yamamoto
2  Tropical Institute of Reproductive Medicine, Cuiabá, MT, Brazil
› Author Affiliations

Abstract

The hyperandrogenism in polycystic ovary syndrome (PCOS) is associated with the risk for the future development of the cardiovascular disease. The objective of the study is to verify whether different androgens have the same harmful effect. This cross-sectional study enrolled 823 women with PCOS: 627 (76.2%) with biochemical hyperandrogenism and 196 (23.8%) with normal androgen levels. The role of individual androgen was evaluated using univariate and multivariate logistic regression. In normoandrogenemic PCOS (NA-PCOS), free androgen index (FAI) predicted significant abnormality in visceral adipose index (VAI, OR=9.2, p=0.002) and dehydroepiandrosterone (DHEA) predicted against alteration in β-cell function (OR=0.5, p=0.007). In hyperandrogenemic PCOS (HA-PCOS), FAI predicted derangements in waist triglyceride index (WTI), VAI, and lipid accumulation product (LAP) (OR ranging from 1.6 to 5.8, p<0.05). DHEA weakly predicted against VAI (OR 0.7, p=0.018), dehydroepiandrosterone sulfate (DHEAS) tended to predict against the conicity index (OR=0.7, p=0.037). After multiple regression, FAI retained significant strength to predict various anthropometric and metabolic abnormalities (OR ranging from 1.1 to 3.0, p<0.01), DHEA was kept as a protector factor against WTI, LAP, and VAI (OR ranging from 0.6 to 0.9; p<0.01) and DHEAS against the conicity index (OR=0.5, p<0.001). In conclusion, the free androgen index was the most powerful predictor of anthropometric and metabolic abnormalities of polycystic ovary syndrome. Conversely, DHEA and DHEAS demonstrated protective effects against disorders in some markers of obesity and abnormal metabolism.

Supplementary Material



Publication History

Received: 22 December 2020

Accepted after revision: 04 March 2021

Publication Date:
20 April 2021 (online)

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