Z Geburtshilfe Neonatol
DOI: 10.1055/a-1410-8379
Original Article

A Question of Timing: 10-year Retrospective Analysis on the Use of Antenatal Steroids for Imminent Preterm Birth

Dieter Matlac
1  Department of Obstetrics and Gynaecology, Universitätsklinikum Schleswig-Holstein – Campus Lübeck, Lübeck, Germany
,
Sinje Jonassen
1  Department of Obstetrics and Gynaecology, Universitätsklinikum Schleswig-Holstein – Campus Lübeck, Lübeck, Germany
,
Mats Ingmar Fortmann
2  Department of Pediatrics, Universitätsklinikum Schleswig-Holstein – Campus Lübeck, Lübeck, Germany
,
Achim Rody
1  Department of Obstetrics and Gynaecology, Universitätsklinikum Schleswig-Holstein – Campus Lübeck, Lübeck, Germany
,
Verena Bossung
1  Department of Obstetrics and Gynaecology, Universitätsklinikum Schleswig-Holstein – Campus Lübeck, Lübeck, Germany
› Author Affiliations
Funding: This study did not receive any funding.

Abstract

Objective Antenatal steroids improve the neonatal outcome if they are administered within a therapeutic window of seven days before preterm birth. The aim of this study was to evaluate the timing of antenatal steroids for imminent preterm birth at a single center in Germany.

Material and Methods A 10-year retrospective analysis of 843 preterm births between 24/0 and 33/6 weeks was performed from January 2008 to December 2017 at a German university hospital. We evaluated the timing of antenatal steroids according to the indication for their application. Descriptive statistics and binomial regression were performed to analyze factors influencing the timing of antenatal steroid administration.

Results Of 843 preterm births below 34 weeks included in our study, 752 pregnant women received antenatal steroids (89.2%). Only 301/843 women (35.7%) gave birth within the optimal window of 7 days after antenatal steroids. 91/843 women (10.8%) did not receive steroids. 130/843 women (15.4%) only received one dose, 76/843 (9.0%) gave birth within 8 to 14 days, and 245/843 (29.1%) more than 14 days later. In a binomial regression model, preterm premature rupture of membranes (OR 3.40, 95% CI 1.81 to 6.39, p<0.001), fetal growth restriction (OR 3.27, 95% CI 1.63 to 6.58, p=0.001), and preeclampsia (OR 2.83, 95% CI 1.37 to 5.83, p=0.005) were positively associated with optimal timing.

Conclusion Two thirds of women with preterm birth before 34 weeks received antenatal steroids outside the optimal therapeutic window. Further research is needed to achieve an optimal effect of antenatal steroids on neonatal outcome and to reduce untimely as well as unnecessary interventions.



Publication History

Received: 24 January 2021

Accepted: 23 February 2021

Publication Date:
22 April 2021 (online)

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