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Zeitschrift für Phytotherapie 2022; 42(05): 229-234
DOI: 10.1055/a-1406-4844
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Echtes Seifenkraut, Saponaria officinalis L.

Thu Ha Ngo
,
MatthiasF. Melzig
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ZUSAMMENFASSUNG

Das Echte Seifenkraut, Saponaria officinalis L., ist eine weit verbreitete Pflanze, die schon seit der Antike wegen ihrer vielfältigen Wirkungen therapeutisch und zu Reinigungszwecken eingesetzt wird. Phytotherapeutisch dienen Saponaria-Drogen wegen ihres Gehaltes an Triterpensaponinen als Expektorans und Sekretolytikum. Die Saponine wirken auch antimykotisch sowie immunstimulierend. Daneben induziert das in den Samen der Pflanze vorkommende Lektin Saporin zytotoxische Effekte und wird gegenwärtig als Bestandteil von Immunotoxinen in der Krebstherapie eingesetzt.

ABSTRACT

Common Soapwort, Saponaria officials L., is a widespread plant that has been used therapeutically and for cleaning purposes since ancient times because of its diverse effects. Phytotherapeutically, Saponaria drugs serve as expectorants and secretolytics because of their content of triterpene saponins. The saponins also have antifungal and immunostimulant effects. In addition, the lectin saporin found in the seeds of the plant induces cytotoxic effects and is currently used as a component of immunotoxins in cancer therapy.

Schlüsselwörter

Saponaria officinalis (L.) - Echtes Seifenkraut - traditionelle Medizin - Pharmakologie - Phytochemie

Key words

Soapwort - Saponaria officinalis (L.) - traditional medicine - pharmacology - phytochemistry


Publication History

Article published online:
24 October 2022

© 2022. Thieme. All rights reserved.

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  • Literatur

  • 1 Berendes J. Des Pedanios Dioskurides aus Anazarbos Arzneimittellehre in fünf Büchern. 2. Buch. Cap. 192. Stuttgart: Ferdinand Enke Verlag; 1902. 241.
    Google Scholar
  • 2 Madaus G. Lehrbuch der biologischen Heilmittel. Bd. III. Hildesheim, New York: Georg Olm Verlag; 1979: 2444-2449
    Google Scholar
  • 3 Fuchs L. Von Seyffenkraut. In: Fuchs L. New Kreüterbuch. Basel 1543. Köln: Taschen-Verlag; 2001. Cap. CCCI
    Google Scholar
  • 4 Karg S, Märkle T. Seifenkraut: Ein (ur-)altes Wasch- und Heilmittel. Archäobotanische Nachweise, Schriftquellen und Experimente zu den Nutzungsmöglichkeiten des Seifenkrautes Saponaria officinalis L. In: Stobbe A, Tegtmeier U, Hrsg. Verzweigungen, Eine Würdigung für A.J. Kalis u. J. Meurers-Balke. Frankfurter Archäologische Schriften. 2012. 18. 159-169
    Google Scholar
  • 5 Sauerhoff F. Etymologisches Wörterbuch der Pflanzennamen. Stuttgart: WVG; 2003: 559-560
    Google Scholar
  • 6 Van Wyk B, Wink C, Wink M. Handbuch der Arzneipflanzen. Stuttgart: WVG; 2015. 315.
    Google Scholar
  • 7 Chirva VY, Kintya PK. Structure of saponosid A. Khim Prir Soedin 1969; 5: 188
    PubMedGoogle Scholar
  • 8 Saponaria rubrae radix. In: Blaschek W, Hrsg. Wichtl Teedrogen und Phytopharmaka. 6. Aufl.. Stuttgart: WVG; 2016: 596-597
    Google Scholar
  • 9 Koike K, Jia Z, Nikaido T. New triterpenoid saponins and sapogenins from Saponaria officinalis . J Nat Prod 1999; 62: 1655-1659
    CrossrefPubMedGoogle Scholar
  • 10 Jurek I, Goral I, Mierzynska Z. et al. Effect of synthetic surfactants and soapwort (Saponaria officinalis L.) extract on skin-mimetic model lipid monolayers. Biochim Biophys Acta Biomembr 2019; 1861: 556-564
    CrossrefPubMedGoogle Scholar
  • 11 Stirpe F, Gasperi-Campani A, Barbieri L. et al. Ribosome-inactivating proteins from the seeds of Saponaria officinalis L. (soapwort), of Agrostemma githago L. (corn cockle) and of Asparagus officinalis L. (asparagus), and from the latex of Hura crepitans L. (sandbox tree). Biochem J 1983; 216: 617-625
    CrossrefPubMedGoogle Scholar
  • 12 Kumar M, Dattagupta S, Kannan KK. et al. Purification, crystallisation and preliminary X-ray diffraction study of ribosome inactivating protein: saporin. Biochim Biophys Acta 1999; 1429: 506-511
    CrossrefPubMedGoogle Scholar
  • 13 Petrović GM, Ilić MD, Stankov-Jovanović VP. et al. Phytochemical analysis of Saponaria officinalis L. shoots and flowers essential oils. Nat Prod Res 2018; 32: 331-334
    CrossrefPubMedGoogle Scholar
  • 14 Schilcher H, Kammerer S, Wegener T. Hrsg. Leitfaden Phytotherapie. 4. Aufl.. München: Elsevier; 2010. 292.
    Google Scholar
  • 15 Hänsel R, Steinegger E. Pharmakognosie – Phytopharmazie. 9. Aufl.. Heidelberg: Springer; 2010: 871-872
    CrossrefGoogle Scholar
  • 16 Sengul M, Ercisli S, Yildiz H. et al. Antioxidant, antimicrobial activity and total phenolic content within the aerial parts of Artemisia absinthium, Artemisia santonicum and Saponaria officinalis . Iran J Pharm Res 2011; 10: 49-56
    PubMedGoogle Scholar
  • 17 Said O, Khamaysi I, Kmail A. et al. In vitro and randomized, double-blind, placebo-controlled trial to determine the efficacy and safety of nine antiacne medicinal plants. Evid Based Complement Alternat Med 2020; 2020: 3231413
    CrossrefPubMedGoogle Scholar
  • 18 Sadowska B, Budzyńska A, Więckowska-Szakiel M. et al. New pharmacological properties of Medicago sativa and Saponaria officinalis saponin-rich fractions addressed to Candida albicans . J Med Microbiol 2014; 63: 1076-1086
    CrossrefPubMedGoogle Scholar
  • 19 Gerabek WE, Haage BD, Keil G, Wegner W. Hrsg. Enzyklopädie Medizingeschichte. Berlin, New York: de Gruyter; 2007. 977.
    CrossrefGoogle Scholar
  • 20 Vonarburg B. Homöotanik. Arzneipflanzen in der Homöopathie. Stuttgart: Haug; 2009: 530-532
    Google Scholar
  • 21 Teuscher E, Lindequist U, Melzig MF. Biogene Arzneimittel. 8. Aufl.. Stuttgart: WVG; 2020: 260-262
    CrossrefGoogle Scholar
  • 22 Wink M, Ashour ML, El-Readi MZ. Secondary metabolites from plants inhibiting ABC transporters and reversing resistance of cancer cells and microbes to cytotoxic and antimicrobial agents. Front Microbiol 2012; 3: 130
    CrossrefPubMedGoogle Scholar
  • 23 Barbieri L. Polynucleotide: adenosine glycosidase activity of saporin-L1: effect on various forms of mammalian DNA. Biochim Biophys Acta 2000; 1480: 258-266
    CrossrefPubMedGoogle Scholar
  • 24 Stirpe F, Bailey S, Miller SP. et al. Modification of ribosomal RNA by ribosome-inactivating proteins from plants. Nucleic Acids Res 1988; 16: 1349-1357
    CrossrefPubMedGoogle Scholar
  • 25 Weng A, Thakur M, von Mallinckrodt B. et al. Saponins modulate the intracellular trafficking of protein toxins. J Control Release 2012; 164: 74-86
    CrossrefPubMedGoogle Scholar
  • 26 Thorpe PE, Brown AN, Bremner JA. et al. An immunotoxin composed of monoclonal anti-Thy 1.1 antibody and a ribosome-inactivating protein from Saponaria officinalis: Potent antitumor effects in vitro and in vivo. J Natl Cancer Inst 1985; 75: 151-159
    PubMedGoogle Scholar
  • 27 Thakur M, Mergel K, Weng A. et al. Targeted tumor therapy by epidermal growth factor appended toxin and purified saponin: an evaluation of toxicity and therapeutic potential in syngeneic tumor bearing mice. Mol Oncol 2013; 7: 475-483
    CrossrefPubMedGoogle Scholar
  • 28 Heisler I, Sutherland M, Bachran C. et al. Combined application of saponin and chimeric toxins drastically enhances the targeted cytotoxicity on tumor cells. J Control Release 2005; 106: 123-137
    CrossrefPubMedGoogle Scholar
  • 29 Weng A, Bachran C, Fuchs H. et al. Enhancement of saporin cytotoxicity by Gypsophila saponins – More than stimulation of endocytosis. Chem Biol Interact 2009; 181: 424-429
    CrossrefPubMedGoogle Scholar
  • 30 Bomford R, Stapleton M, Winsor S. et al. Adjuvanticity and ISCOM formation by structurally diverse saponins. Vaccine 1992; 10: 572-577
    CrossrefPubMedGoogle Scholar
  • 31 Turmagambetova AS, Alexyuk PG, Bogoyavlenskiy AP. et al. Adjuvant activity of saponins from Kazakhstani plants on the immune responses to subunit influenza vaccine. Arch Virol 2017; 162: 3817-3826
    CrossrefPubMedGoogle Scholar
  • 32 Sama S, Jerz G, Thakur M. et al. Structure-activity relationship of transfection-modulating saponins – A pursuit for the optimal gene trafficker. Planta Med 2019; 85: 513-518
    Article in Thieme ConnectPubMedGoogle Scholar
  • 33 Sidhu GS, Oakenfull DG. A mechanism for the hypocholesterolaemic activity of saponins. Br J Nutr 1986; 55: 643-649
    CrossrefPubMedGoogle Scholar
  • 34 Budan A, Bellenot D, Freuze I. et al. Potential of extracts from Saponaria officinalis and Calendula officinalis to modulate in vitro rumen fermentation with respect to their content in saponins. Biosci Biotechnol Biochem 2014; 78: 288-295
    CrossrefPubMedGoogle Scholar
  • 35 Francis G, Kerem Z, Makkar HP. et al. The biological action of saponins in animal systems: a review. Br J Nutr 2002; 88: 587-605
    CrossrefPubMedGoogle Scholar
  • 36 Sefrioui MR, El Othmani IS, Filali H. et al. Evaluation of spermicidal activity of saponosides from Saponaria officinalis/Caryophyllaceae, Glycyrrhizia glabra/Fabaceae and Herniaria glabra/Caryophyllaceae. Med Pharm Rep 2021; 94: 239-247
    PubMedGoogle Scholar
  • 37 Polito L, Bortolotti M, Mercatelli D. et al. Saporin-S6: a useful tool in cancer therapy. Toxins (Basel) 2013; 5: 1698-1722
    CrossrefPubMedGoogle Scholar
  • 38 Böttger S. Untersuchungen zur synergistischen Zytotoxizität zwischen Saponinen und Ribosomen inaktivierenden Proteinen Typ 1 [Dissertation]. Freie Universität Berlin. 2013
    PubMedGoogle Scholar
  • 39 Jia Z, Koike K, Nikaido T. Major triterpenoid saponins from Saponaria officinalis . J Nat Prod 1998; 61: 1368-1373
    CrossrefPubMedGoogle Scholar