Seltene Erkrankungen der Orbita

Zusammenfassung

Dieser Übersichtsartikel stellt eine Zusammenstellung seltener Erkrankungen der Orbita dar. Es werden angeborene Fehlbildungen und strukturelle Läsionen, entzündliche Erkrankungen, gutartige und bösartige epitheliale sowie nicht epitheliale Tumoren erörtert. Da in der Orbita zahlreiche Gewebetypen auf engstem Raum beieinanderliegen, kommen dort besonders viele Erkrankungen vor, sodass der Vollständigkeit und dem Tiefgang bei den einzelnen Abhandlungen natürliche Grenzen gesetzt sind. Die Kapitel beinhalten eine Übersicht über das jeweilige klinische Erscheinungsbild, wichtige Stichpunkte zur Diagnostik, Therapie und gegebenenfalls zur Prognose der Erkrankung. Dabei wurde versucht, die besonders charakteristischen Merkmale der einzelnen Erkrankungen herauszuarbeiten, sodass trotz der kurzen Darstellung die relevanten Aspekte enthalten sind.

Schlüsselwörter

Tumor - Entzündung - Fehlbildung - Gefäßanomalie

Publication History

Article published online:
30 April 2021

• Literatur

• 1 Poloschek CM, Lagreze WA, Ridder GJ. et al. [Clinical and neuroradiological diagnostics of orbital tumors]. Ophthalmologe 2011; 108: 510-518
• 2 Plontke SK, Glien A, Kisser U. et al. [Diseases and Surgery of the Orbit]. Laryngorhinootologie 2020; 99: 896-917
• 3 AWMF. Rekonstruktion von Orbitadefekten (S2e-Leitlinie), Registernummer: 007/099. In: Arbeitsgemeinschaft medizinisch wissenschaftlicher Fachgesellschaften (AWMF); 2013
• 4 Fay A, Dolman PJ. Laboratory Serologic Investigations.In Fay A, Dolman PJ , Hrsg. Diseases and Disorders of the Orbit and Ocular Adnexa E-book. Elsevier; 2017: 57–77
• 5 Bonavolonta G, Tranfa F, de Conciliis C. et al. Dermoid cysts: 16-year survey. Ophthalmic Plast Reconstr Surg 1995; 11: 187-192
• 6 Jordan DR, Spitellie P, Brownstein S. et al. Orbital cholesterol granuloma and cholesteatoma: significance of differentiating the two. Ophthalmic Plast Reconstr Surg 2007; 23: 415-417
• 7 Sherman RP, Rootman J, Lapointe JS. Orbital dermoids: clinical presentation and management. Br J Ophthalmol 1984; 68: 642-652
• 8 Shields JA, Kaden IH, Eagle RC. et al. Orbital dermoid cysts: clinicopathologic correlations, classification, and management. The 1997 Josephine E. Schueler Lecture. Ophthalmic Plast Reconstr Surg 1997; 13: 265-276
• 9 Delfini R, Missori P, Iannetti G. et al. Mucoceles of the paranasal sinuses with intracranial and intraorbital extension: report of 28 cases. Neurosurgery 1993; 32: 901-906 discussion 906
• 10 Heichel J, Struck HG, Hammer T. et al. [Pediatric acute dacryocystitis due to frontoethmoidal mucocele]. HNO 2019; 67: 458-462
• 11 Nicollas R, Facon F, Sudre-Levillain I. et al. Pediatric paranasal sinus mucoceles: etiologic factors, management and outcome. Int J Pediatr Otorhinolaryngol 2006; 70: 905-908
• 12 Holtmann C, Brachert M, Spaniol K. et al. [Dacryolith in a lacrimal duct]. Ophthalmologe 2016; 113: 244-247
• 13 Tanaboonyawat S, Idowu OO, Copperman TS. et al. Dacryops - A review. Orbit 2020; 39: 128-134
• 14 Junemann A, Holbach LM. [Epithelial giant inclusion cyst 50 years after enucleation without orbital implant]. Klin Monbl Augenheilkd 1998; 212: 127-128
• 15 Kalantzis GK, Verity DH, Rose GE. Periocular implantation cysts: a late complication of ophthalmic surgery. Eye (Lond) 2014; 28: 1004-1007
• 16 Gupta R, Seith A, Guglani B. et al. Congenital cystic eye: features on MRI. Br J Radiol 2007; 80: e137-140
• 17 Guthoff R, Klein R, Lieb WE. Congenital cystic eye. Graefes Arch Clin Exp Ophthalmol 2004; 242: 268-271
• 18 Kuchle HJ, Normann J, Lubbering I. [Congenital cystic eye]. Klin Monbl Augenheilkd 1986; 188: 239-241
• 19 Schittkowski MP, Guthoff RF. Injectable self inflating hydrogel pellet expanders for the treatment of orbital volume deficiency in congenital microphthalmos: preliminary results with a new therapeutic approach. Br J Ophthalmol 2006; 90: 1173-1177
• 20 Schittkowski MP, Guthoff RF. Systemic and ophthalmological anomalies in congenital anophthalmic or microphthalmic patients. Br J Ophthalmol 2010; 94: 487-493
• 21 Badtke G, Tost M. Anophthalmus congenitus.In Velhagen K , Hrsg. Der Augenarzt, Band XI. Leipzig: VEB Georg Thieme; 1986: 328–344
• 22 Badtke G, Tost M. Mikrophthalmus congenitus.In Velhagen K , Hrsg. Der Augenarzt, Band XI. Leipzig: VEB Georg Thieme; 1986: 312–328
• 23 Chaudhry IA, Arat YO, Shamsi FA. et al. Congenital microphthalmos with orbital cysts: distinct diagnostic features and management. Ophthalmic Plast Reconstr Surg 2004; 20: 452-457
• 24 Oguz H, Ozturk A, San I. Congenital nasolacrimal duct occlusion with clinical anophthalmos: a possible new association. Ophthalmic Genet 2003; 24: 181-185
• 25 Pejic M, Luecke K, Meoded A. et al. Pediatric Cephaloceles: A Multimodality Review. Appl Radiol 2020; 49: 26-32
• 26 Terry A, Patrinely JR, Anderson RL. et al. Orbital meningoencephalocele manifesting as a conjunctival mass. Am J Ophthalmol 1993; 115: 46-49
• 27 Vashisht S, Ghai S, Hatimota P. et al. Cystic lesions of the orbit : A CT spectrum. Indian Journal of Radiology and Imaging 2003; 13: 139
• 28 Modi P, Shah NA, Bhalodia JN. et al. ORBITAL TUMORS IN CHILDREN: A DESCRIPTIVE STUDY AT TERTIARY CARE CENTRE. The Journal of medical research 2013; 3: 362-366
• 29 Green WR, Zimmerman LE. Ectopic lacrimal gland tissue. Report of eight cases with orbital involvement. Arch Ophthalmol 1967; 78: 318-327
• 30 Scheiner AJ, Frayer WC, Rorke LB et al. Ectopic brain tissue in the orbit. Eye (Lond) 1999; 13: ( Pt 2) 251–254
• 31 Damato PJ, Damato FJ. Neonatal Orbital Teratoma. Br J Ophthalmol 1962; 46: 685-691
• 32 Herman TE, Vachharajani A, Siegel MJ. Massive congenital orbital teratoma. J Perinatol 2009; 29: 396-397
• 33 Sesenna E, Ferri A, Thai E. et al. Huge orbital teratoma with intracranial extension: a case report. J Pediatr Surg 2010; 45: e27-31
• 34 Duke-Elder S. Anomalies of the Bony Orbit. In: Duke-Elder S, Hrsg. System of Ophthalmology Vol III: Normal and abnormal Development Part 2, Congenital Deformities: Henry Kimpton. 1964: 942-949
• 35 Exner S, Bogusch G, Sokiranski R. Cribra orbitalia visualized in computed tomography. Ann Anat 2004; 186: 169-172
• 36 Islam N, Mireskandari K, Rose GE. Orbital varices and orbital wall defects. Br J Ophthalmol 2004; 88: 833-834
• 37 Duke-Elder S. Deformities of the Face.In Duke-Elder S , Hrsg. System of Ophthalmology Vol III: Normal and abnormal Development Part 2, Congenital Deformities: Henry Kimpton. 1964; 1007–1035
• 38 Kawamoto HK. The kaleidoscopic world of rare craniofacial clefts: order out of chaos (Tessier classification). Clin Plast Surg 1976; 3: 529-572
• 39 Fearon JA. Rare craniofacial clefts: a surgical classification. J Craniofac Surg 2008; 19: 110-112
• 40 Tessier P. Anatomical classification facial, cranio-facial and latero-facial clefts. J Maxillofac Surg 1976; 4: 69-92
• 41 Heike CL, Hing AV, Aspinall CA. et al. Clinical care in craniofacial microsomia: a review of current management recommendations and opportunities to advance research. Am J Med Genet C Semin Med Genet 2013; 163C: 271-282
• 42 Dupont S, Catala M, Hasboun D. et al. Progressive facial hemiatrophy and epilepsy: a common underlying dysgenetic mechanism. Neurology 1997; 48: 1013-1018
• 43 Fea AM, Aragno V, Briamonte C. et al. Parry Romberg syndrome with a wide range of ocular manifestations: a case report. BMC Ophthalmol 2015; 15: 119
• 44 Duke-Elder S. Deformities of the Skull.In Duke-Elder S , Hrsg. System of Ophthalmology Vol III: Normal and abnormal Development Part 2, Congenital Deformities: Henry Kimpton. 1964: 1035–1072
• 45 Freudlsperger C, Castrillón-Oberndorfer G, Hoffmann J. et al. Isolierte, nichtsyndromale Kraniosynostosen. Der MKG-Chirurg 2013; 6: 301-313
• 46 Governale LS. Craniosynostosis. Pediatr Neurol 2015; 53: 394-401
• 47 Kotrikova B, Muhling J. [Surgery of craniofacial deformities]. Klin Monbl Augenheilkd 2004; 221: 970-977
• 48 Wilkie AOM, Johnson D, Wall SA. Clinical genetics of craniosynostosis. Curr Opin Pediatr 2017; 29: 622-628
• 49 Mundlos S. Cleidocranial dysplasia: clinical and molecular genetics. J Med Genet 1999; 36: 177-182
• 50 Dubourg C, Bendavid C, Pasquier L. et al. Holoprosencephaly. Orphanet J Rare Dis 2007; 2: 8
• 51 Lustig LR, Holliday MJ, McCarthy EF. et al. Fibrous dysplasia involving the skull base and temporal bone. Arch Otolaryngol Head Neck Surg 2001; 127: 1239-1247
• 52 Stark Z, Savarirayan R. Osteopetrosis. Orphanet J Rare Dis 2009; 4: 5
• 53 Lannon DA, Earley MJ. Cherubism and its charlatans. Br J Plast Surg 2001; 54: 708-711
• 54 Grass S, Welkoborsky HJ, Mobius H. et al. [Orbital complications]. HNO 2018; 66: 800-811
• 55 Lehnerdt G, Peraud A, Berghaus A. et al. [Orbital and intracranial complications of acute sinusitis. Diagnostics and therapy in children and adolescents]. HNO 2011; 59: 75-86 quiz 87-78
• 56 Stammberger H. [Complications of inflammatory paranasal sinus diseases including iatrogenically-induced complications]. Eur Arch Otorhinolaryngol Suppl 1993; 1: 61-102
• 57 Welkoborsky HJ, Grass S, Deichmuller C. et al. Orbital complications in children: differential diagnosis of a challenging disease. Eur Arch Otorhinolaryngol 2015; 272: 1157-1163
• 58 Hamed-Azzam S, AlHashash I, Briscoe D. et al. Rare Orbital Infections ~ State of the Art ~ Part II. J Ophthalmic Vis Res 2018; 13: 183-190
• 59 Rootman J. Diseases of the orbit.Second edition Aufl. Lippincott Williams & Wilkins; Philadelphia: 2003
• 60 Madge SN, Prabhakaran VC, Shome D. et al. Orbital tuberculosis: a review of the literature. Orbit 2008; 27: 267-277
• 61 Fay A, Dolman PJ. Diseases and Disorders of the Orbit and Ocular Adnexa Expert Consult. In Fay A, Dolman PJ (eds). Elsevier; 2017
• 62 Heichel J, Griebsch M, Siebolts U. et al. [Bilateral periocular necrotizing fasciitis with unilateral orbital involvement]. Ophthalmologe 2020; 117: 1121-1125
• 63 Huber L, Budjan J, Rotter N. et al. [Necrotizing fasciitis in the head and neck region-three case reports and a review of the literature]. HNO 2020; 68: 935-943
• 64 Amrith S, Hosdurga Pai V, Ling WW. Periorbital necrotizing fasciitis -- a review. Acta Ophthalmol 2013; 91: 596-603
• 65 Wong CH, Chang HC, Pasupathy S. et al. Necrotizing fasciitis: clinical presentation, microbiology, and determinants of mortality. J Bone Joint Surg Am 2003; 85: 1454-1460
• 66 Lazzeri D, Lazzeri S, Figus M. et al. Periorbital necrotising fasciitis. Br J Ophthalmol 2010; 94: 1577-1585
• 67 Wladis EJ, Levin F, Shinder R. Clinical Parameters and Outcomes in Periorbital Necrotizing Fasciitis. Ophthalmic Plast Reconstr Surg 2015; 31: 467-469
• 68 Federspil P. German Society of Oto-Rhino-Laryngology H, Neck S. [Guidelines: Antibiotic treatment of infections of the head and neck: consensus report on behalf of the presidency of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery edited by P. Federspil, Homburg/Saar]. . HNO 2009; 57: 377-394
• 69 Barrani M, Massei F, Scaglione M. et al. Unusual onset of a case of chronic recurrent multifocal osteomyelitis. Pediatr Rheumatol Online J 2015; 13: 60
• 70 Dagan O, Barak Y, Metzker A. Pyoderma gangrenosum and sterile multifocal osteomyelitis preceding the appearance of Takayasu arteritis. Pediatr Dermatol 1995; 12: 39-42
• 71 Huber AM, Lam PY, Duffy CM. et al. Chronic recurrent multifocal osteomyelitis: clinical outcomes after more than five years of follow-up. J Pediatr 2002; 141: 198-203
• 72 Hu AC, Ng WKY. Orbital Osteomyelitis in the Pediatric Patient. J Craniofac Surg 2021; 32: 206-209
• 73 Cornely OA, Alastruey-Izquierdo A, Arenz D. et al. Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium. Lancet Infect Dis 2019; 19: e405-e421
• 74 Bakhshaee M, Bojdi A, Allahyari A. et al. Acute invasive fungal rhinosinusitis: our experience with 18 cases. Eur Arch Otorhinolaryngol 2016; 273: 4281-4287
• 75 van Burik JA, Hare RS, Solomon HF. et al. Posaconazole is effective as salvage therapy in zygomycosis: a retrospective summary of 91 cases. Clin Infect Dis 2006; 42: e61-65
• 76 Songu M, Unlu HH, Gunhan K. et al. Orbital exenteration: A dilemma in mucormycosis presented with orbital apex syndrome. Am J Rhinol 2008; 22: 98-103
• 77 Nicolai P, Lombardi D, Tomenzoli D. et al. Fungus ball of the paranasal sinuses: experience in 160 patients treated with endoscopic surgery. Laryngoscope 2009; 119: 2275-2279
• 78 Johnson TE, Casiano RR, Kronish JW. et al. Sino-orbital aspergillosis in acquired immunodeficiency syndrome. Arch Ophthalmol 1999; 117: 57-64
• 79 Levin LA, Avery R, Shore JW. et al. The spectrum of orbital aspergillosis: a clinicopathological review. Surv Ophthalmol 1996; 41: 142-154
• 80 Siddiqui AA, Shah AA, Bashir SH. Craniocerebral aspergillosis of sinonasal origin in immunocompetent patients: clinical spectrum and outcome in 25 cases. Neurosurgery 2004; 55: 602-611 discussion 611-603
• 81 Nielsen EW, Weisman RA, Savino PJ. et al. Aspergillosis of the sphenoid sinus presenting as orbital pseudotumor. Otolaryngol Head Neck Surg 1983; 91: 699-703
• 82 Sivak-Callcott JA, Livesley N, Nugent RA. et al. Localised invasive sino-orbital aspergillosis: characteristic features. Br J Ophthalmol 2004; 88: 681-687
• 83 Lamoth F, Calandra T. Early diagnosis of invasive mould infections and disease. J Antimicrob Chemother 2017; 72: i19-i28
• 84 McCarthy M, Rosengart A, Schuetz AN. et al. Mold infections of the central nervous system. N Engl J Med 2014; 371: 150-160
• 85 Green WR, Font RL, Zimmerman LE. Asperillosis of the orbit. Report of ten cases and review of the literature. Arch Ophthalmol 1969; 82: 302-313
• 86 Denning DW. Therapeutic outcome in invasive aspergillosis. Clin Infect Dis 1996; 23: 608-615
• 87 Robert Koch-Institut. Infektionsepidemiologisches Jahrbuch meldepflichtiger Krankheiten für 2019 Berlin: Robert Koch-Institut; 2020
• 88 Gomez Morales A, Croxatto JO, Crovetto L. et al. Hydatid cysts of the orbit. A review of 35 cases. Ophthalmology 1988; 95: 1027-1032
• 89 Xiao A, Xueyi C. Hydatid cysts of the orbit in Xinjiang: a review of 18 cases. Orbit 1999; 18: 151-155
• 90 Kars Z, Kansu T, Ozcan OE. et al. Orbital echinococcosis. Report of two cases studied by computerized tomography. J Clin Neuroophthalmol 1982; 2: 197-199
• 91 Chtira K, Benantar L, Aitlhaj H. et al. The surgery of intra-orbital hydatid cyst: a case report and literature review. Pan Afr Med J 2019; 33: 167
• 92 Senyuz OF, Yesildag E, Celayir S. Albendazole therapy in the treatment of hydatid liver disease. Surg Today 2001; 31: 487-491
• 93 Pushker N, Bajaj MS, Balasubramanya R. Disseminated cysticercosis involving orbit, brain and subcutaneous tissue. J Infect 2005; 51: e245-248
• 94 Walrath JD, Lalin SC, Leib ML. Cysticercosis isolated to the orbit. Ophthalmic Plast Reconstr Surg 2003; 19: 243-244
• 95 Sotelo J, Escobedo F, Rodriguez-Carbajal J. et al. Therapy of parenchymal brain cysticercosis with praziquantel. N Engl J Med 1984; 310: 1001-1007
• 96 Nentwich MM, Pleyer U, Schaller UC. et al. [International ophthalmology and travel medicine]. Ophthalmologe 2016; 113: 83-94
• 97 Mombaerts I, Rose GE, Garrity JA. Orbital inflammation: Biopsy first. Surv Ophthalmol 2016; 61: 664-669
• 98 Ben Simon GJ, Yoon MK, Atul J. et al. Clinical manifestations of orbital mass lesions at the Jules Stein Eye Institute, 1999-2003. Ophthalmic Surg Lasers Imaging 2006; 37: 25-32
• 99 Nölle B, Both M. Idiopathische Orbitaentzündung.In Pleyer U , Hrsg. Entzündliche Augenerkrankungen. Berlin, Heidelberg: Springer- Verlag; 2016: 48–57
• 100 Swamy BN, McCluskey P, Nemet A. et al. Idiopathic orbital inflammatory syndrome: clinical features and treatment outcomes. Br J Ophthalmol 2007; 91: 1667-1670
• 101 Fujii H, Fujisada H, Kondo T. et al. Orbital pseudotumor: histopathological classification and treatment. Ophthalmologica 1985; 190: 230-242
• 102 Mombaerts I, Goldschmeding R, Schlingemann RO. et al. What is orbital pseudotumor?. Surv Ophthalmol 1996; 41: 66-78
• 103 Rootman J, Nugent R. The classification and management of acute orbital pseudotumors. Ophthalmology 1982; 89: 1040-1048
• 104 Rootman J, McCarthy M, White V. et al. Idiopathic sclerosing inflammation of the orbit. A distinct clinicopathologic entity. Ophthalmology 1994; 101: 570-584
• 105 Iaconetta G, Stella L, Esposito M. et al. Tolosa-Hunt syndrome extending in the cerebello-pontine angle. Cephalalgia 2005; 25: 746-750
• 106 Speth MM, Metternich FU, Mina R. et al. Tolosa-Hunt-Syndrom, das sich als migrierende, auf Kortikosteroid reagierende CN3- und CN6-Lähmung bei verschatteten Keilbeinhöhlen darstellt. forum hno: omnimed Verlag 05/2020;
• 107 Halabi T, Sawaya R. Successful Treatment of Tolosa-Hunt Syndrome after a Single Infusion of Infliximab. J Clin Neurol 2018; 14: 126-127
• 108 Mormont E, Laloux P, Vauthier J. et al. Radiotherapy in a case of Tolosa-Hunt syndrome. Cephalalgia 2000; 20: 931-933
• 109 Perez CA, Evangelista M. Evaluation and Management of Tolosa-Hunt Syndrome in Children: A Clinical Update. Pediatr Neurol 2016; 62: 18-26
• 110 Zhang X, Zhang W, Liu R. et al. Factors that influence Tolosa-Hunt syndrome and the short-term response to steroid pulse treatment. J Neurol Sci 2014; 341: 13-16
• 111 Espinoza GM, Liu JL. Orbital Vasculitides-Differential Diagnosis. Curr Rheumatol Rep 2019; 21: 54
• 112 Tiegs-Heiden CA, Eckel LJ, Hunt CH. et al. Immunoglobulin G4-related disease of the orbit: imaging features in 27 patients. AJNR Am J Neuroradiol 2014; 35: 1393-1397
• 113 Erdei A, Steiber Z, Molnar C. et al. Exophthalmos in a young woman with no graves' disease - a case report of IgG4-related orbitopathy. BMC Ophthalmol 2018; 18: 5
• 114 Jurkov M, Olze H, Klauschen F. et al. [IgG4-Related Orbitopathy as an Important Differential Diagnosis of Advanced Silent Sinus Syndrome. German version]. HNO 2020; 68: 864-868
• 115 Mulholland GB, Jeffery CC, Satija P. et al. Immunoglobulin G4-related diseases in the head and neck: a systematic review. J Otolaryngol Head Neck Surg 2015; 44: 24
• 116 Detiger SE, Karim AF, Verdijk RM. et al. The treatment outcomes in IgG4-related orbital disease: a systematic review of the literature. Acta Ophthalmol 2019; 97: 451-459
• 117 Plaza JA, Garrity JA, Dogan A. et al. Orbital inflammation with IgG4-positive plasma cells: manifestation of IgG4 systemic disease. Arch Ophthalmol 2011; 129: 421-428
• 118 Perumal B, Black EH, Levin F. et al. Non-infectious orbital vasculitides. Eye (Lond) 2012; 26: 630-639
• 119 Sfiniadaki E, Tsiara I, Theodossiadis P. et al. Ocular Manifestations of Granulomatosis with Polyangiitis: A Review of the Literature. Ophthalmol Ther 2019; 8: 227-234
• 120 Mukhtyar C, Flossmann O, Hellmich B. et al. Outcomes from studies of antineutrophil cytoplasm antibody associated vasculitis: a systematic review by the European League Against Rheumatism systemic vasculitis task force. Ann Rheum Dis 2008; 67: 1004-1010
• 121 Holle JU, Voigt C, Both M. et al. Orbital masses in granulomatosis with polyangiitis are associated with a refractory course and a high burden of local damage. Rheumatology (Oxford) 2013; 52: 875-882
• 122 Perry SR, Rootman J, White VA. The clinical and pathologic constellation of Wegener granulomatosis of the orbit. Ophthalmology 1997; 104: 683-694
• 123 Chang SY, Keogh KA, Lewis JE. et al. IgG4-positive plasma cells in granulomatosis with polyangiitis (Wegener's): a clinicopathologic and immunohistochemical study on 43 granulomatosis with polyangiitis and 20 control cases. Hum Pathol 2013; 44: 2432-2437
• 124 Martinez Del Pero M, Chaudhry A, Jones RB. et al. B-cell depletion with rituximab for refractory head and neck Wegener's granulomatosis: a cohort study. Clin Otolaryngol 2009; 34: 328-335
• 125 Takanashi T, Uchida S, Arita M. et al. Orbital inflammatory pseudotumor and ischemic vasculitis in Churg-Strauss syndrome: report of two cases and review of the literature. Ophthalmology 2001; 108: 1129-1133
• 126 Cottin V, Cordier JF. Churg-Strauss syndrome. Allergy 1999; 54: 535-551
• 127 Masi AT, Hunder GG, Lie JT. et al. The American College of Rheumatology 1990 criteria for the classification of Churg-Strauss syndrome (allergic granulomatosis and angiitis). Arthritis Rheum 1990; 33: 1094-1100
• 128 Vaglio A, Moosig F, Zwerina J. Churg-Strauss syndrome: update on pathophysiology and treatment. Curr Opin Rheumatol 2012; 24: 24-30
• 129 Guillevin L, Lhote F, Gayraud M. et al. Prognostic factors in polyarteritis nodosa and Churg-Strauss syndrome. A prospective study in 342 patients. Medicine (Baltimore) 1996; 75: 17-28
• 130 Nagel MA, White T, Khmeleva N. et al. Analysis of Varicella-Zoster Virus in Temporal Arteries Biopsy Positive and Negative for Giant Cell Arteritis. JAMA Neurol 2015; 72: 1281-1287
• 131 Borruat FX, Bogousslavsky J, Uffer S. et al. Orbital infarction syndrome. Ophthalmology 1993; 100: 562-568
• 132 Stone JH, Tuckwell K, Dimonaco S. et al. Trial of Tocilizumab in Giant-Cell Arteritis. N Engl J Med 2017; 377: 317-328
• 133 Seyahi E. Takayasu arteritis: an update. Curr Opin Rheumatol 2017; 29: 51-56
• 134 Tugal-Tutkun I. Systemic vasculitis and the eye. Curr Opin Rheumatol 2017; 29: 24-32
• 135 Misra DP, Wakhlu A, Agarwal V. et al. Recent advances in the management of Takayasu arteritis. Int J Rheum Dis 2019; 22 (Suppl. 01) 60-68
• 136 Iliescu DA, Timaru CM, Batras M. et al. Cogan's Syndrome. Rom J Ophthalmol 2015; 59: 6-13
• 137 Tayer-Shifman OE, Ilan O, Tovi H. et al. Cogan's syndrome--clinical guidelines and novel therapeutic approaches. Clin Rev Allergy Immunol 2014; 47: 65-72
• 138 Grasland A, Pouchot J, Hachulla E. et al. Typical and atypical Cogan's syndrome: 32 cases and review of the literature. Rheumatology (Oxford) 2004; 43: 1007-1015
• 139 Gluth MB, Baratz KH, Matteson EL. et al. Cogan syndrome: a retrospective review of 60 patients throughout a half century. Mayo Clin Proc 2006; 81: 483-488
• 140 Padoan R, Cazzador D, Pendolino AL. et al. Cogan's syndrome: new therapeutic approaches in the biological era. Expert Opin Biol Ther 2019; 19: 781-788
• 141 Kokturk A. Clinical and Pathological Manifestations with Differential Diagnosis in Behcet's Disease. Patholog Res Int 2012; 2012: 690390
• 142 Hammami S, Yahia SB, Mahjoub S. et al. Orbital inflammation associated with Behcet's disease. Clin Exp Ophthalmol 2006; 34: 188-190
• 143 Urruticoechea-Arana A, Cobo-Ibanez T, Villaverde-Garcia V. et al. Efficacy and safety of biological therapy compared to synthetic immunomodulatory drugs or placebo in the treatment of Behcet's disease associated uveitis: a systematic review. Rheumatol Int 2019; 39: 47-58
• 144 Bettiol A, Silvestri E, Di Scala G. et al. The right place of interleukin-1 inhibitors in the treatment of Behcet's syndrome: a systematic review. Rheumatol Int 2019; 39: 971-990
• 145 Hedrich CM, Schnabel A, Hospach T. Kawasaki Disease. Front Pediatr 2018; 6: 198
• 146 Demirsoy S, Gucuyener K, Olgunturk R. et al. A case of Kawasaki syndrome associated with preseptal cellulitis in orbita. Turk J Pediatr 1988; 30: 55-59
• 147 Felz MW, Patni A, Brooks SE. et al. Periorbital vasculitis complicating Kawasaki syndrome in an infant. Pediatrics 1998; 101: E9
• 148 Sheard RM, Pandey KR, Barnes ND. et al. Kawasaki disease presenting as orbital cellulitis. J Pediatr Ophthalmol Strabismus 2000; 37: 123-125
• 149 Son MB, Gauvreau K, Burns JC. et al. Infliximab for intravenous immunoglobulin resistance in Kawasaki disease: a retrospective study. J Pediatr 2011; 158: 644-649 e641
• 150 Read RW. Clinical mini-review: systemic lupus erythematosus and the eye. Ocul Immunol Inflamm 2004; 12: 87-99
• 151 Arthurs BP, Khalil MK, Chagnon F. et al. Orbital infarction and melting in a patient with systemic lupus erythematosus. Ophthalmology 1999; 106: 2387-2390
• 152 Nabili S, McCarey DW, Browne B. et al. A case of orbital myositis associated with rheumatoid arthritis. Ann Rheum Dis 2002; 61: 938-939
• 153 Sanchez IJ, Finger DR, Bradshaw DJ. Orbital inflammatory syndrome and systemic lupus erythematosus. J Clin Rheumatol 1995; 1: 295-298
• 154 Kokotis P, Theodossiadis P, Bouros C. et al. Bilateral ocular myositis as a late complication of dermatomyositis. J Rheumatol 2005; 32: 379-381
• 155 Lokdarshi G, Pushker N, Bajaj MS. Sclerosing Lesions of the Orbit: A Review. Middle East Afr J Ophthalmol 2015; 22: 447-451
• 156 Petrarolha SM, Rodrigues BS, Filho FD. et al. Unilateral Eyelid Edema as Initial Sign of Orbital Sarcoidosis. Case Rep Ophthalmol Med 2016; 2016: 6912927
• 157 Rosenbaum JT, Choi D, Wilson DJ. et al. Parallel Gene Expression Changes in Sarcoidosis Involving the Lacrimal Gland, Orbital Tissue, or Blood. JAMA Ophthalmol 2015; 133: 770-777
• 158 Mavrikakis I, Rootman J. Diverse clinical presentations of orbital sarcoid. Am J Ophthalmol 2007; 144: 769-775
• 159 Demirci H, Christianson MD. Orbital and adnexal involvement in sarcoidosis: analysis of clinical features and systemic disease in 30 cases. Am J Ophthalmol 2011; 151: 1074-1080 e1071
• 160 McNab AA. The 2017 Doyne Lecture: the orbit as a window to systemic disease. Eye (Lond) 2018; 32: 248-261
• 161 Pasadhika S, Rosenbaum JT. Ocular Sarcoidosis. Clin Chest Med 2015; 36: 669-683
• 162 Aluclu MU, Keklikci U, Guzel A. et al. Melkersson-Rosenthal syndrome with partial oculomotor nerve palsy. Ann Saudi Med 2008; 28: 135-137
• 163 Shapiro M, Peters S, Spinelli HM. Melkersson-Rosenthal syndrome in the periocular area: a review of the literature and case report. Ann Plast Surg 2003; 50: 644-648
• 164 Cocuroccia B, Gubinelli E, Annessi G. et al. Persistent unilateral orbital and eyelid oedema as a manifestation of Melkersson-Rosenthal syndrome. J Eur Acad Dermatol Venereol 2005; 19: 107-111
• 165 Pierre-Filho Pde T, Rocha EM, Natalino R. et al. Upper eyelid oedema in Melkersson-Rosenthal syndrome. Clin Exp Ophthalmol 2004; 32: 439-440
• 166 Khandpur S, Malhotra AK, Khanna N. Melkersson-Rosenthal syndrome with diffuse facial swelling and multiple cranial nerve palsies. J Dermatol 2006; 33: 411-414
• 167 Rawlings NG, Valenzuela AA, Allen LH. et al. Isolated eyelid edema in Melkersson-Rosenthal syndrome: a case series. Eye (Lond) 2012; 26: 163-166
• 168 Ramaswamy B, Singh R, Manusrut M. et al. Sclerosing lipogranuloma of the eyelid: unusual complication following nasal packing in endoscopic sinus surgery. BMJ Case Rep. 2015 2015.
• 169 Witschel H, Geiger K. Paraffin induced sclerosing lipogranuloma of eyelids and anterior orbit following endonasal sinus surgery. Br J Ophthalmol 1994; 78: 61-65
• 170 Herrmann B, Rozot P, Baylac F. et al. [Lipogranuloma of the orbit. Apropos of a case]. J Fr Ophtalmol 1996; 19: 780-784
• 171 AlGhafri L, Galindo-Ferreiro A, Maktabi A. et al. Idiopathic orbital lipogranuloma. Int J Ophthalmol 2017; 10: 494-496
• 172 Jakobiec FA, Rai R, Rashid A. et al. Bilateral Eyelid Pseudoptosis From Lipogranulomas of the Preaponeurotic Fat Pads. Ophthalmic Plast Reconstr Surg 2015; 31: e125-131
• 173 Paik JS, Cho WK, Park GS. et al. Eyelid-associated complications after autogenous fat injection for cosmetic forehead augmentation. BMC Ophthalmol 2013; 13: 32
• 174 Park JY, Kim N. Periorbital Lipogranuloma after Facial Autologous Fat Injection and Its Treatment Outcomes. Korean J Ophthalmol 2016; 30: 10-16
• 175 Cafaro G, Croia C, Argyropoulou OD. et al. One year in review 2019: Sjogren's syndrome. Clin Exp Rheumatol 2019; 37 (Suppl. 118) 3-15
• 176 Mathews PM, Hahn S, Hessen M. et al. Ocular complications of primary Sjogren syndrome in men. Am J Ophthalmol 2015; 160: 447-452 e441
• 177 Danlos FX, Daoued F, Seror R. et al. Orbital Myositis and Primary Sjogren Syndrome. J Rheumatol 2015; 42: 1536-1537
• 178 Tonami H, Matoba M, Kuginuki Y. et al. Clinical and imaging findings of lymphoma in patients with Sjogren syndrome. J Comput Assist Tomogr 2003; 27: 517-524
• 179 Luemsamran P, Rootman J, White VA. et al. The role of biopsy in lacrimal gland inflammation: A clinicopathologic study. Orbit 2017; 36: 411-418
• 180 Ohshima K, Matsuo N, Yokoe S. et al. [A case of lacrimal gland malignant lymphoma, associated with Sjogren's syndrome]. Nippon Ganka Gakkai Zasshi 1991; 95: 386-392
• 181 Carubbi F, Cipriani P, Marrelli A. et al. Efficacy and safety of rituximab treatment in early primary Sjogren's syndrome: a prospective, multi-center, follow-up study. Arthritis Res Ther 2013; 15: R172
• 182 Kimura T. On the unusual granulations combined with hyperplastic changes of lymphatic tissue. Trans Soc Pathol Jpn 1948; 37: 179-180
• 183 Buder K, Ruppert S, Trautmann A. et al. Angiolymphoid hyperplasia with eosinophilia and Kimura's disease - a clinical and histopathological comparison. J Dtsch Dermatol Ges 2014; 12: 224-228
• 184 Claros P, Fokouo V, Nyada F. et al. Kimura's disease of the orbit: A modern diagnostic challenge. Eur Ann Otorhinolaryngol Head Neck Dis 2017; 134: 287-289
• 185 Googe PB, Harris NL, Mihm MC. Kimura's disease and angiolymphoid hyperplasia with eosinophilia: two distinct histopathological entities. J Cutan Pathol 1987; 14: 263-271
• 186 Kodama T, Kawamoto K. Kimura's disease of the lacrimal gland. Acta Ophthalmol Scand 1998; 76: 374-377
• 187 Monzen Y, Kiya K, Nishisaka T. Kimura's Disease of the Orbit Successfully Treated with Radiotherapy Alone: A Case Report. Case Rep Ophthalmol 2014; 5: 87-91
• 188 Bullock JD, Bartley GB, Campbell RJ. et al. Necrobiotic xanthogranuloma with paraproteinemia. Case report and a pathogenetic theory. Ophthalmology 1986; 93: 1233-1236
• 189 Shams PN, Rasmussen SL, Dolman PJ. Adult-Onset Asthma Associated With Simultaneous Conjunctival, Eyelid, and Orbital Xanthogranulomatosis Responsive to Systemic Immunosuppression. Ophthalmic Plast Reconstr Surg 2015; 31: e162-163
• 190 Elner VM, Mintz R, Demirci H. et al. Local corticosteroid treatment of eyelid and orbital xanthogranuloma. Ophthalmic Plast Reconstr Surg 2006; 22: 36-40
• 191 Efebera Y, Blanchard E, Allam C. et al. Complete response to thalidomide and dexamethasone in a patient with necrobiotic xanthogranuloma associated with monoclonal gammopathy: a case report and review of the literature. Clin Lymphoma Myeloma Leuk 2011; 11: 298-302
• 192 Cives M, Simone V, Rizzo FM. et al. Erdheim-Chester disease: a systematic review. Crit Rev Oncol Hematol 2015; 95: 1-11
• 193 Estrada-Veras JI, O'Brien KJ, Boyd LC. et al. The clinical spectrum of Erdheim-Chester disease: an observational cohort study. Blood Adv 2017; 1: 357-366
• 194 Merritt H, Pfeiffer ML, Richani K. et al. Erdheim-Chester disease with orbital involvement: Case report and ophthalmic literature review. Orbit 2016; 35: 221-226
• 195 Manousaridis K, Casper J, Schittkowski MP. et al. [Erdheim-Chester disease of the orbit with compressive optic neuropathy]. Ophthalmologe 2010; 107: 266-269
• 196 Veyssier-Belot C, Cacoub P, Caparros-Lefebvre D. et al. Erdheim-Chester disease. Clinical and radiologic characteristics of 59 cases. Medicine (Baltimore) 1996; 75: 157-169
• 197 Altman J, Winkelmann RK. Diffuse normolipemic plane xanthoma. Generalized xanthelasma. Arch Dermatol 1962; 85: 633-640
• 198 Zak IT, Altinok D, Neilsen SS. et al. Xanthoma disseminatum of the central nervous system and cranium. AJNR Am J Neuroradiol 2006; 27: 919-921
• 199 Khezri F, Gibson LE, Tefferi A. Xanthoma disseminatum: effective therapy with 2-chlorodeoxyadenosine in a case series. Arch Dermatol 2011; 147: 459-464
• 200 Minkov M, Lehrnbecher T. S1-Leitlinie 025/015 „Langerhanszell-Histiozytose (LCH) im Kindesalter In. 2017
• 201 Bertelmann E, Minko N, Lohneis P. et al. Benigne Neoplasien der Orbita. Klin Monatsbl Augenheilkd 2011; 228: 1113-1130
• 202 Maccheron LJ, McNab AA, Elder J. et al. Ocular adnexal Langerhans cell histiocytosis clinical features and management. Orbit 2006; 25: 169-177
• 203 Esmaili N, Harris GJ. Langerhans Cell Histiocytosis of the Orbit: Spectrum of Disease and Risk of Central Nervous System Sequelae in Unifocal Cases. Ophthalmic Plast Reconstr Surg 2016; 32: 28-34
• 204 Vemuganti GK, Naik MN, Honavar SG. Rosai dorfman disease of the orbit. J Hematol Oncol 2008; 1: 7
• 205 Bothra N, Kaliki S, Gowrishankar S. et al. Isolated unilateral eyelid Rosai-Dorfman disease. Oman J Ophthalmol 2018; 11: 300-302
• 206 Rosai J, Dorfman RF. Sinus histiocytosis with massive lymphadenopathy. A newly recognized benign clinicopathological entity. Arch Pathol 1969; 87: 63-70
• 207 Foucar E, Rosai J, Dorfman R. Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): review of the entity. Semin Diagn Pathol 1990; 7: 19-73
• 208 McClellan SF, Ainbinder DJ. Orbital Rosai-Dorfman disease: a literature review. Orbit 2013; 32: 341-346
• 209 Ezeanosike E, Ezeanosike OB, Akpan SI. et al. Rhabdomyoblastic differentiation in rosai dorfman disease of the orbit in a 12-year-old male. Niger J Clin Pract 2018; 21: 1670-1673
• 210 Fajgenbaum DC, van Rhee F, Nabel CS. HHV-8-negative, idiopathic multicentric Castleman disease: novel insights into biology, pathogenesis, and therapy. Blood 2014; 123: 2924-2933
• 211 Goel R, Raut A, Agarwal A. et al. A Rare Presentation of Orbital Castleman's Disease. Case Rep Ophthalmol Med 2020; 2020: 1012759
• 212 Schrock A, Gutgemann I, Keiner S. [Castleman's disease in ear, nose, and throat practice]. HNO 2007; 55 (Suppl. 01) E29-32
• 213 Talat N, Belgaumkar AP, Schulte KM. Surgery in Castleman's disease: a systematic review of 404 published cases. Ann Surg 2012; 255: 677-684
• 214 van Rhee F, Wong RS, Munshi N. et al. Siltuximab for multicentric Castleman's disease: a randomised, double-blind, placebo-controlled trial. Lancet Oncol 2014; 15: 966-974
• 215 Kesper C, Viestenz A, Siebolts U. et al. [Orbital Amyloidosis - Comparison of Two Different Clinical Courses]. Klin Monbl Augenheilkd 2020; 237: 35-40
• 216 Leibovitch I, Selva D, Goldberg RA. et al. Periocular and orbital amyloidosis: clinical characteristics, management, and outcome. Ophthalmology 2006; 113: 1657-1664
• 217 Mora-Horna ER, Rojas-Padilla R, Lopez VG. et al. Ocular adnexal and orbital amyloidosis: a case series and literature review. Int Ophthalmol 2016; 36: 281-298
• 218 Naxer S, Behnes CL, Schittkowski MP. [Amyloidosis--a rare differential diagnosis of an orbital tumour]. Klin Monbl Augenheilkd 2011; 228: 555-564
• 219 Ladner-Merz S, Muller-Ladner U. [Amyloidoses]. Z Rheumatol 2008; 67: 677-682 quiz 683
• 220 Khaira M, Mutamba A, Meligonis G. et al. The use of radiotherapy for the treatment of localized orbital amyloidosis. Orbit 2008; 27: 432-437
• 221 Eghbali A, Hassan S, Seehra G. et al. Ophthalmological findings in Gaucher disease. Mol Genet Metab 2019; 127: 23-27
• 222 Prakalapakorn SG, Proia AD, Yanovitch TL. et al. Ocular and histologic findings in a series of children with infantile pompe disease treated with enzyme replacement therapy. J Pediatr Ophthalmol Strabismus 2014; 51: 355-362
• 223 Slingerland NW, Polling JR, van Gelder CM. et al. Ptosis, extraocular motility disorder, and myopia as features of pompe disease. Orbit 2011; 30: 111-113
• 224 Winter AW, Salimi A, Ospina LH. et al. Ophthalmic manifestations of Gaucher disease: the most common lysosomal storage disorder. Br J Ophthalmol 2019; 103: 315-326
• 225 Yanovitch TL, Banugaria SG, Proia AD. et al. Clinical and histologic ocular findings in pompe disease. J Pediatr Ophthalmol Strabismus 2010; 47: 34-40
• 226 Wabbels B, Ali N, Kunz WS. et al. [Chronic progressive external ophthalmoplegia and Kearns-Sayre syndrome : interdisciplinary diagnosis and therapy]. Ophthalmologe 2008; 105: 550-556
• 227 Pfeiffer MJ. [Chronic Progressive External Ophthalmoplegia Ptosis: Problems with Diagnostics and Treatment]. Klin Monbl Augenheilkd 2018; 235: 31-33
• 228 Pitceathly RD, Morrow JM, Sinclair CD. et al. Extra-ocular muscle MRI in genetically-defined mitochondrial disease. Eur Radiol 2016; 26: 130-137
• 229 Rahman S, Blok RB, Dahl HH. et al. Leigh syndrome: clinical features and biochemical and DNA abnormalities. Ann Neurol 1996; 39: 343-351
• 230 McKelvie P, Infeld B, Marotta R. et al. Late-adult onset Leigh syndrome. J Clin Neurosci 2012; 19: 195-202
• 231 Lake NJ, Compton AG, Rahman S. et al. Leigh syndrome: One disorder, more than 75 monogenic causes. Ann Neurol 2016; 79: 190-203
• 232 Han J, Lee YM, Kim SM. et al. Ophthalmological manifestations in patients with Leigh syndrome. Br J Ophthalmol 2015; 99: 528-535
• 233 Fichter N, Schittkowski M, Guthoff R. Erkrankungen der Tränendrüse. Ophthalmologe 2005; 102: 399-425
• 234 Moreiras J. Tumors of the lacrimal gland - Orbit – examination, diagnosis, mircrosurgery, pathology. 2004
• 235 Font R, Gamel J. Epithelial tumours of the lacrimal gland: an analysis of 265 cases.In Jakobiec F (ed) Ocular and adnexal tumours. Aesculapius, Birmingham. 1978
• 236 Riedel K, Markl A, Hasenfratz G. et al. Epithelial tumors of the lacrimal gland: Clinico-pathologic correlation and management. Neurosurg Rev 1990; 13: 289-298
• 237 Andreasen S, Esmaeli B, Holstein L. et al. An Update on Tumors of the Lacrimal Gland. Asia-Pac. J Ophthalmol 2017; 6: 159-172
• 238 Cates C, Manners R, Rose G. Pleomorphic adenoma of the lacrimal gland in a 10 year old girl. Br J Ophthalmol 2002; 86: 249-250
• 239 Faktorovich E, Crawford J, Char D. Benign mixed tumor (pleomorphic adenoma) of the lacrimal gland in a 6-year-old boy. Am J Ophthalmol 1996; 122: 446-447
• 240 Mercado G, Gunduz K, Shields C. et al. Pleomorphic adenoma of the lacrimal gland in a teenager. Arch Ophthalmol 1998; 116: 962-963
• 241 Ni C, Kuo P, Dryja T. Histopathological classification of 272 primary epithelial tumors of the lacrimal gland. Chin Med J 1992; 105: 481-485
• 242 Rose G, Wright J. Pleomorphic adenoma of the lacrimal gland. Br J Ophthalmol 1992; 76: 395-400
• 243 Stefko S, DiBernardo C, Green W. et al. Pleomorphic adenoma of the lacrimal gland with extensive calcification. Arch Ophthalmol 2004; 122: 778-780
• 244 Stupp T, Pavlidis M, Buchner T. Pleomorphic Adenoma of the Lacrimal Gland in a Child After Treatmentof Acute Lymphoblastic Leukemia. Arch Ophthalmol 2004; 122: 1538-1540
• 245 Bonavolontà G, Tranfa F, Staibano S. et al. Warthin Tumor of the Lacrimal Gland. Am J Ophthalmol 1997; 124: 857-858
• 246 Ghosh D, Ekka J. Adenolymphoma of the lacrimal gland: A very rare case report. Int J Ocul Oncol oculoplasty 2018; 4: 144-145
• 247 Bartoletti-Stella A, Salfi N, Ceccarelli C. et al. Mitochondrial DNA Mutations in Oncocytic Adnexal Lacrimal Glands of the Conjunctiva. ARCH OPHTHALMOL 2011; 129: 664-666
• 248 Calle C, Castillo I, Eagle R. et al. Oncocytoma of the Lacrimal Gland: Case Report and Review of the Literature. Orbit 2006; 25: 243-247
• 249 Cameron J, Barras C. Oncocytoma of the eyelid. ACTA OPHTHALMOL SCAND 2004; 83: 125
• 250 George E, Swanson P, Newman B. et al. Oculocutaneous oncocytic tumors: clinicopathologic and immunohistochemical study of 2 cases with literature review. Am J Dermatopathol 2007; 29: 279-285
• 251 Morand B, Bettega G, Bland V. et al. Oncocytoma of the eyelid: an aggressive benign tumor. Ophthalmology 1998; 105: 2220-2224
• 252 Shields C, Shields J. Tumors of the conjunctiva and cornea. Survey of Ophthalmology 2004; 49: 3-24
• 253 Shields C, Shields J, Arbizo V. Oncocytoma of the caruncle. Am J Ophthalmol 1986; 102: 315-319
• 254 Surakiatchanukul T, Sioufi K, Pointdujour-Lim R. et al. Caruncular Oncocytoma Mimicking Malignant Melanoma. Ocul Oncol Pathol 3: 320-323
• 255 Bolzoni A, Pianta L, Farina D. et al. Benign myoepithelioma of the lacrimal gland: report of a case. Eur Arch Otorhinolaryngol 2005; 262: 186-188
• 256 Font R, Garner A. Myoepithelioma of the lacrimal gland: report of a case with spindle cell morphology. Brit J Ophthalmol 1992; 76: 634-636
• 257 Grossniklaus H, Wojno T, Wilson M. et al. Myoepithelioma of the Lacrimal Gland. Arch Ophthalmol 1997; 115: 1588-1590
• 258 Heathcote J, Hurwitz J, Dardick I. A Spindle-Cell Myoepithelioma of the Lacrimal Gland. Arch Ophthalmol 1990; 108: 1135-1139
• 259 Nickol T, E R Kleinsasser O. Myoepitheliome der Parotis. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde. 1998
• 260 Bajaj M, Pushker N, Kashyap S. Cystadenoma of the lacrimal gland. Orbit 2002; 21: 301-305
• 261 Bernardini F, Devoto M. JO C. Epithelial tumors of the lacimal gland: an update. Curr Opin in Ophthalmol 2008; 19: 409-413
• 262 Silbert J, Braich P, Misra R. Basal cell cystadenoma of the lacrimal gland: diagnostic pitfalls of a basaloid pattern in lacrimal tumours. Internat Ophthalmol. 2011 DOI: 43-46
• 263 Wang L, Zhang SK, Ma Y. et al. Papillary cystadenoma of the parotid gland: A case report. World J Clin Cases 2019; 7: 366-372
• 264 Pfeiffer M, Yin V, Bell D. et al. Sclerosing Polycystic Adenosis of the Lacrimal Gland. Ophthalmology 2013; 120: 873
• 265 Speight P, Barrett A. Salivary gland tumours: diagnostic challenges and an update on the latest WHO classification. Diagn Histopathol 2020; 26: 147-158
• 266 Brunnmann R, Ro J, Ordonez N. et al. Extrapleural Solitary Fibrous Tumor: A Clinicopathologic Study of 24 Cases. Mod Pathol 1999; 12: 1034-1042
• 267 Mupas-Uy J, Kitaguchia Y, Takahashia Y. et al. Solitary Fibrous Tumor in the Lacrimal Gland Fossa: A Case Report. Case Rep Ophthalmol 2016; 7: 398-403
• 268 Okike N, Bernatz P, Woolner L. Localized mesothelioma of the pleura. Benign and malignant variants. J Thorac Cardiovasc Surg 1978; 75: 363-372
• 269 Scott I, Tanenbaum M, Rubin D. Solitary fibrous tumor of the lacrimal gland fossa. Ophthalmology 1996; 103: 1613-1618
• 270 Vallat-Decouvelaere A, Dry S, Fletcher C. Atypical and malignant solitary fibrous tumor in extrathoracic locations; evidence of their comparability to intra-thoracic tumors. Am J Surg Pathol 1998; 22: 1501-1511
• 271 Woo K, Suh Y, Kim Y. Solitary fibrous tumor of the lacrimal sac. Ophthalmic Plast Reconstr Surg 1999; 15: 450-453
• 272 Bielory BP, Turbin RE, Mirani NM. et al. Radiographic and histological findings in an atypical orbital myxoma. Ophthalmol Eye Dis 2011; 3: 55
• 273 Demirci H, Shields CL, Eagle RCJ. et al. Report of a conjunctival myxoma case and review of the literature. Arch Ophthalmol 2006; 124: 735-738
• 274 Kini Rao A, Nayal B. Conjunctival myxoma-a case report. Malays J Med Sci 2013; 20: 92-94
• 275 Parikh D, Mukherjee B. Lacrimal gland myxoma. Indian J Ophthalmol 2017; 65: 887-889
• 276 Rambhatla S, Subramanian N, Gangadhara Sundar JK. et al. Myxoma of the orbit. Indian J Ophthalmol 2003; 51: 85-87
• 277 Bajaj M, Pushker N, Fibrous SK. histiocytoma of the lacrimal gland. Ophthal Plast Reconstr Surg 2007; 23: 145-147
• 278 Andrew N, Coupland S, Pirbhai A. et al. Lymphoid hyperplasia of the orbit and ocular adnexa: A clinical pathologic review. Survey of Ophthalmology 2016; 61: 778-790
• 279 Shields J, Shields C, Scartozzi R. Survey of 1264 patients with orbital tumors and simulating lesions: the 2002 Montgomery lecture, part 1. Ophtalmology. 2004 DOI: 997-1008
• 280 Wittekind C. TNM-Klassifikation maligner Tumoren. Achte Auflage. Aufl. WILEY-VCH; 2017
• 281 Devoto M, Croxatto J. Primary cystadenocarcinoma of the lacrimal gland. Ophthalmology 2003; 110: 2006-2010
• 282 Takahira M, Nakamura Y, Shimizu S. et al. Carcinosarcoma of the Lacrimal Gland Arising From a Pleomorphic Adenoma. Am J Ophthalmol 2005; 140: 340-341
• 283 Daisuke Y, Toshiyuki O, Shuichi Y. Case of primary neuroendocrine carcinoma in lacrimal gland. Acta Ophthalmol 2013; 91: 252
• 284 Gess A, Silkiss R. A merkel cell carcinoma of the lacrimal gland. Ophthal Plast Reconstr Surg. 28. 11-13
• 285 El-Naggar A, Chan J, Grandis J. World Health organization classification of head and neck tumours. 2017 DOI:
• 286 Weis E, Rootman J, Joly T. et al. Epithelial lacrimal gland tumors: pathologic classification and current understanding. Arch Ophthalmol 2009; 127: 1016-1028
• 287 Gamel J, Font R. Adenoidcystic carcinoma of the lacrimal gland: the clinical significance of a basaoid histologic pattern. Human Pathol 1982; 13: 219-225
• 288 Friedrich R, Bleckmann V. Adenoid cystic carcinoma of the salivary and lacrimal glands origin: localization, classification, clinical pathological correlation, treatment results and long-term follow-up control in 84 patients. Anticancer Res 2003; 23: 937-940
• 289 Goldberg R. Intraarterial chemotherapy. A welcome new idea for the management of adenoidcystic carcinoma of the lacrimal gland. Arch Ophthalmol 1998; 116: 372-373
• 290 Hamper K, Lazar F, Dietel M. Prognostic factors for adenoid cystic carcinoma of the head and neck: a retrospectiv evaluation of 96 cases. J Oral Pathol Med 1990; 19: 101-107
• 291 Henderson J. In Orbital Tumors New York: Raven Press;. 1994: 323-342
• 292 Lee D, Campbell R, Waller R. A clinicopathologic study of primary adenoid cystic carcinoma of the lacrimal gland. Ophthalmology 1985; 92: 128-134
• 293 Strianese D, Baldi G, Staibano S. Expression of apoptosis-related markers in malignant epithelial tumors of the lacrimal gland and their relation to clinical outcome. Br J Ophthalmol 2007; 91: 1239-1243
• 294 Tse D, Benedetto P, Dubovy S. Clinical analysis oft he effect on intraarterial cytoreductive chemotherapy in the treatment of lacrimal gland andoid cystic carcinoma. Am J Ophthalmol 2006; 141: 44-53
• 295 Wright J, Rose G, Garner A. Primary malignant neoplasms of the lacrimal gland. Br J Ophthalmol 1992; 76: 401-407
• 296 Karcioglu Z. Orbital Tumors. Diagnosis and Management. New York: Springer; 2005
• 297 Ahmad S, Esmaeli B, Williams M. American Joint Committee on Cancer classification predicts outcome of patients with lacrimal gland adenoid cystic carcinoma. Ophthalmology 2009; 116: 1210-1215
• 298 GROUP IHANS. Cervical lymph node metastasis in adenoid cystic carcinoma of the sinonasal tract, nasopharynx, lacrimal glands and external auditory canal: a collective international review. J Laryngol Otol 2016; 130: 1093-1097
• 299 Xiao R, Sethi R, Feng A. et al. The role of elective neck dissection in patients with adenoid cystic carcinoma of the head and neck. Laryngoscope 2019; 129: 2094-2104
• 300 Bördlein I. Mit schweren Ionen gegen hartnäckige Tumoren. Deutsches Ärzteblatt 2004; 101: 1718-1720
• 301 Hayashi K, Koto M, Ikawa H. et al. Efficacy and safety of carbon-ion radiotherapy for lacrimal gland carcinomas with extraorbital extension: a retrospective cohort study. Oncotarget 2018; 9: 12932-12940
• 302 Lesueur P, Rapeaud E, De Marzi L. et al. Adenoid Cystic Carcinoma of the Lacrimal Gland: High Dose Adjuvant Proton Therapy to Improve Patients Outcomes. Front Oncol 2020; 10: 135
• 303 Wolkow N, Jakobiec F, Lee H. et al. Long-term Outcomes of Globe-Preserving Surgery With Proton Beam Radiation for Adenoid Cystic Carcinoma of the Lacrimal Gland. Am J Ophthalmol. 2018 195.
• 304 Shields J, Shields C, Freire J. Plaque radiotherapy for selected orbital malignancies: preliminary observations: hte 2002 Montgomery Lecture, part 2. Ophthal Plast Reconstr Surg 2003; 19: 91-95
• 305 Tyl J, Blank L, Koornneef L. Brachytherapy in orbital tumors. Ophthalmology 1997; 104: 1475-1479
• 306 Gündüz A, Yesiltas Y, Shileds C. Overview of benign and malignant lacrimal gland tumors. Curr Opin Ophthalmol 2018; 29: 458-468
• 307 Ashton N. Epithelial tumors of the lacrimal gland. Mod Probl Ophthalmol 1975; 14: 306-323
• 308 Perzin K, Jakobiec F, Lovolsi V. Lacrimal gland malignant mixed tumors (carcinomas arising in benign mixed tumors): a clinicopathologic study. Cancer 1980; 45: 2593-2606
• 309 Shields C, Shields J, Eagle R. Clinicopathologic review of 142 cases of lacrimal gland lesions. Ophthalmology 1989; 96: 431-435
• 310 Henderson J, Farrow G. Primary malignant mixed tumors of the lacrimal gland. Report of 10 cases. Ophthalmology 1980; 87: 466-475
• 311 Jakobiec F, Bilyk J, Font R. Ophthalmic Pathology. An Atlas and Textbook. 4th ed. Aufl. Philadelphia. WB Saunders; 1996
• 312 Chen A, Garcia J, Bucci M. et al. The role of postoperative radiation therapy in carcinoma ex pleomorphic adenoma of the parotid gland. Int J Radiat Oncol Biol Phys 2007; 67: 138-143
• 313 Takahira M, Minato H, Takahashi M. Cystic carcinoma ex pleomorphic adenoma of the lacrimal gland. Ophthal Plast Reconstr Surg 2007; 23: 407-409
• 314 Hwang S, Kim K. High-grade Mucoepidermoid Carci- noma of the Lacrimal Gland. Korean J Ophthalmol 2018; 32: 426-427
• 315 Heaps R, Miller N, Albert D. Primary adenocarcinoma of the lacrimal gland. Ophtalmology 1993; 100: 1856-1860
• 316 von Holstein S, Coupland S. , D B. Epithelial Tumors of the Lacrimal Gland: a clinical, histopathological, surgical, and oncological survey. Acta Ophthalmol 2013; 91: 195-206
• 317 Dennie T. Metastastic her-2 amplified lacrimal gland carcinoma with response to lapatinib treatment. Case Rep Oncol Med 2015; 2015: 1-3
• 318 Totuk O, Demir M, Yapicier O. et al. Low-Grade Mucoepidermoid Carcinoma of the Lacrimal Gland in a Teenaged Patient. Case Rep Ophthalmol Med. 2017
• 319 Eviatar J, Hornblass A. Mucoepidermoid carcinoma of the lacrimal gland: 25 cases and a review and update of the literature. Ophthal Plast Reconstr Surg 1993; 9: 170-181
• 320 Sofinski S, Brown B, Rao N. Mucoepidermoid carcinoma of the lacrimal gland. Case report and review of the literature. Ophthalmic Plast Reconstr Surg 1986; 2: 147-151
• 321 Thorvaldsson S, Beahrs O, Woolner L. et al. Mucoepidermoid tumors of the major salivary glands. Am J Surg 1970; 120: 432-438
• 322 Katz E, Rootman J, Dolman P. et al. Primary Ductal Adenocarcinoma of the Lacrimal Gland. Ophthalmology 1996; 103: 157-162
• 323 Yang H, Wu C, Tsai C. et al. Primary ductal adenocarcinoma of lacrimal gland: Two case reports and review of the literature. Taiwan J Ophthalmol 2018; 8: 42-48
• 324 Ishida M, Hotta M, Kushima R. et al. Case of ductal adenocarcinoma ex pleomorphic adenoma of the lacrimal gland. Rinsho Byori 2009; 57: 746-751
• 325 Andreasen S, Grauslund M, Heegaard S. Lacrimal gland ductal carcinomas: clinical, morphological and genetic characterization and implications for targeted treatment. Acta Ophthalmol 2017; 95: 299-306
• 326 Jaspers H, Verbist B, Schoffelen R. et al. Androgen Receptor–Positive Salivary Duct Carcinoma: A Disease Entity With Promising New Treatment Options. J Clin Oncol 2011; 29: 473-476
• 327 See T, Stålhammar G, Tang T. et al. Primary ductal adenocarcinoma of the lacrimal gland: A review and report of five cases. Survey of Ophthalmology 2020; 65: 371-380
• 328 Anesi A, Negrello S, Lucchetti D. et al. Clinical Management of Acinic Cell Carcinoma of the Lacrimal Gland. Case Rep Oncol 2019; 12: 777-790
• 329 De Rosa G, Zeppa P, Tranta F. Acinic Cell Carcinoma in a Lacrimal Gland: first case report. Cancer 1986; 57: 1988-1991
• 330 Jang J, Kie J, Lee S. Acinic cell carcinoma of the lacrimal gland with intracranial extension. Ophthalmic Plast Reconstr Surg 2001; 17: 454-457
• 331 Rosenbaum P, Mahadevia P, Goodman L. Acinic cell carcinoma of the lacrimal gland. Arch Ophthalmol 1995; 113: 781-785
• 332 Briscoe D, Mahmood S, Bonshek R. et al. Primary sebaceous carcinoma of the lacrimal gland. Br J Ophthalmol 2001; 85: 625-626
• 333 Harvey P, Parsons M, Rennie I. Primary sebaceous carcinoma of lacrimal gland: a previously unreported primary neoplasm. Eye 1994; 8: 592-595
• 334 Kiratli H, Tarlan B, Fırat P. Primary sebaceous carcinoma of the lacrimal gland. Orbit 2012; 31: 352-354
• 335 Park H, Choi S. Primary sebaceous carcinoma of lacrimal gland: A case report and review of literature. World J Clin Cases 2018; 6: 1194-1198
• 336 Yamamoto N, Mizoe J, Hasegawa A. et al. Primary sebaceous carcinoma of the lacrimal gland treated by carbon ion radiotherapy. Int J Clin Oncol 2003; 8: 386-390
• 337 Herrera G. Light microscopic, ultrastructural and immunocytochemical spectrum of malignant lacrimal and salsivary gland tumors, including malignant mixed tumors. Pathobiology 1990; 58: 312-322
• 338 Iida K, Shikishima K, Okido M. et al. A case of malignant myoepithelioma in the lacrimal gland. Nippon Ganka Gakkai Zasshi 2001; 105: 42-46
• 339 Larbcharoensub N, Pangpunyakulchai D, Aroonroch R. et al. Lacrimal myoepithelial carcinoma ex recurrent pleomorphic adenoma: A clinicopathological report and review of the literature. Mol Clin Oncol 2018; 8: 209-213
• 340 Nagao T, Sugano I, Ishida Y. Salivary gland mmalignant myoepithelioma: a clinicopathologic and immunohistochemical study of ten cases. Cancer 1998; 83: 1292-1299
• 341 Xu T, Liao Z, Tang J. et al. Myoepithelial carcinoma of the headand neck: A report of 23 casesand literature review. Cancer Treatment. Communications 2014; 2: 24-29
• 342 Mahdi Y, Azami M, Daoudi R. et al. Diagnostic pitfall: primary myoepithelial carcinoma of the lacrimal gland, case report and literature review. BMC Clinical Pathology 2018; 18: 1-7
• 343 Yu G, Ma D, Sun K. Myoepithelial carcinoma of the salivary glands: behavior and management. Chin Med J 2003; 116: 163-165
• 344 Soumarová R, Lovasová Z, Vaňková M. Radiotherapy in malignant myoepithelioma of the soft palate – case report. Case Rep Oncol 2009; 2: 116-120
• 345 Nieder C, Schneller F, Grosu A. Radiotherapy and chemotherapy for myoepithelioma of the sellar region. Strahlenther Onkol 2005; 181: 260-263
• 346 Fenton S, Srinivasan S, Harnett A. et al. Primary squamous cell carcinoma of the lacrimal gland. Eye 2003; 17: 424-425
• 347 Su G, Patipa M, Font R. Primary squamous cell carcinoma arising from an epithelium-lined cyst of the lacrimal gland. Ophthal Plast Reconstr Surg 2005; 21: 383-385
• 348 Hotta K, Arisawa T, Mito H. et al. Primary squamous cell carcinoma of the lacrimal gland. Clin Experiment Ophthalmol 2005; 33: 534-536
• 349 Bernardini F, Orcioni G, Croxatto J. Oncocytic carcinoma of the lacrimal gland in a patient with neurofibromatosis. Ophthal Plast Reconstr Surg 2010; 26: 486-488
• 350 Kalantzis G, Norris J, El-Hindy N. et al. Oncocytic adenocarcinoma of the lacrimal gland: an unusual presentation. Eye 2013; 27: 104-105
• 351 Selva D, Davis G, Dodd T. Polymorphous Low-Grade Adenocarcinoma of the Lacrimal Gland. ARCH OPHTHALMOL 2004; 122: 915-917
• 352 Bortz J, Zhang P, Eagle R. et al. Secretory Carcinoma of the Lacrimal Gland: A Rare Case Report. Ophthalmic Plast Reconstr Surg 2018; 34: 154-157
• 353 Hyrczaa M, Andreasen S, Melchiorc L. et al. Primary Secretory Carcinoma of the Lacrimal Gland: Report of a New Entity. Am J Ophthalmol 2018; 193: 178-183
• 354 Kadir S. Synovial Sarcoma involving lacrimal gland: A rare clinical entity. Int J Ocu Oncol Oculoplast. 1: 14–18
• 355 Likhvantseva V, Safonova T, Kuzmin K. Primary granulocytic sarcoma of lacrimal gland. Vestn Oftalmol 2016; 132: 82-89
• 356 Yilmaz A, Saydam G, Sahin F. et al. Granulocytic sarcoma: a systematic review. Am J Blood Res 2013; 3: 265-270
• 357 Rajabi M, Riazi H, Hosseini S. et al. Malignant Peripheral Nerve Sheath Tumor of Lacrimal Nerve: A Case Report. Orbit 2015; 34: 41-44
• 358 Stark A, Hugo H, Buhl R. et al. Tumoren peripherer Nerven. Dtsch Arztebl 2002; 99: 928-933
• 359 Gündüz K, Shields J, Eagle R.. Malignant Rhabdoid Tumor of the Orbit. Arch Ophthalmol 1998; 116: 243-246
• 360 Johnson L, Sexton F, Goldberg S. Poorly differentiated primary orbital sarcoma (presumed malignant rhabdoid tumor): radiologic and histopathologic correlation. Arch Ophthalmol 1991; 109: 1275-1278
• 361 Orphanet. Rhabdoidtumor. In: Orphanet; 2020
• 362 Rootman J, Damji K, Dimmick J. Malignant rhabdoid tumor of the orbit. Ophthalmology 1989; 96: 1650-1654
• 363 Walford N, Deferrai R, Slater R. Intraorbital rhabdoid tumour following bilateral retinoblastoma. Histopathology 1992; 20: 170-173
• 364 Niffenegger J, Jakobiec F, Shore J. et al. Adult extrarenal rhabdoid tumor of the lacrimal gland. Ophthalmology 1992; 99: 567-574
• 365 Ferry J, Fung C, Zukerberg L. et al. Lymphoma of the ocular adnexa: A study of 353 cases 2007; 31: 170-184
• 366 Rasmussen P, Ralfkiaer E, Prause J. Malignant lymphoma of the lacrimal gland. A nation-based study. Arch Ophthalmol 2011; 129: 1275-1280
• 367 Johnson T, Tse D, Byrne G. Ocular adnexal lymphoid tumors: a clinicopathologic and molecular genetic study of 77 patients. Ophthal Plast Reconstr Surg 1999; 15: 171-179
• 368 Polito E, Galieni P, Leccisotti A. Clinical and radiological presentation of 95 orbital lymphoid tumors. Graefes Arch Clin Exp Ophthalmol 1996; 234: 504-509
• 369 Aranow M. Ocular adnexal lymphoma: evidence-based treatment approach. Int Ophthalmol Clin 2015; 55: 97-109
• 370 König L, Stade R, Rieber J. Radiotherapy of indolent orbital lymphomas: two radiation concepts. Strahlenther Onkol 2016; 192: 414-421
• 371 de Leval L, Jaffe E. Lymphoma Classification. Cancer J 2020; 26: 176-185
• 372 Shields J, Shields C, Eagle R. Metastatic renal cell carcinoma to the palpebral lobe of the lacrimal gland. Ophthal Plast Reconstr Surg 2001; 17: 191-194
• 373 Fowler J, Terplan K. Fibroma of the Orbit. Arch Ophthalmol 1942; 28: 263-271
• 374 Mortada A. Fibroma of the orbit. Brit J Ophthal 1971; 55: 350
• 375 Rong A, Ulloa-Padilla J, Blessing N. et al. Subperiosteal fibroma of the orbit. Orbit 2018; 37: 378-380
• 376 Rabelo N, da Silva V, do Espírito Santo M. et al. Orbit ossifying fibroma – Case report and literature review. Surg Neurol Int 2020; 11: 35
• 377 Sheikh BY. Cranial aneurysmal bone cyst “with special emphasis on endovascular management”. Acta Neurochir (Wien) 1999; 141: 601-610 discussion 610-601
• 378 Glien A, Meyer B, Wernert N. et al. [Orbital aneurysmal bone cyst in a 2-year-old child]. HNO 2007; 55: 281-286
• 379 Wang JC, Zhang M, Zhao XX. Aneurysmal bone cyst of the orbit. Chin Med J (Engl) 2015; 128: 562-563
• 380 Yu JW, Kim KU, Kim SJ. et al. Aneurysmal bone cyst of the orbit : a case report with literature review. J Korean Neurosurg Soc 2012; 51: 113-116
• 381 Ruiter DJ, van Rijssel TG, van der Velde EA. Aneurysmal bone cysts: a clinicopathological study of 105 cases. Cancer 1977; 39: 2231-2239
• 382 Biesecker JL, Marcove RC, Huvos AG. et al. Aneurysmal bone cysts. A clinicopathologic study of 66 cases. Cancer 1970; 26: 615-625
• 383 Schajowicz F. Tumors and tumorlike lesions of bone 2. Aufl. Berlin-Heidelberg-New York: Springer-Verlag; 1994
• 384 Oliveira AM, Chou MM. USP6-induced neoplasms: the biologic spectrum of aneurysmal bone cyst and nodular fasciitis. Hum Pathol 2014; 45: 1-11
• 385 Fay A, Dolman PJ. Laboratory Serologic Investigations.In Fay A, Dolman PJ , Hrsg. Diseases and Disorders of the Orbit and Ocular Adnexa E-book. Elsevier; 2017: 314
• 386 Mallen JR, Caranfa JT, Zimmerman D. et al. Atypical presentation of a solid-variant orbital aneurysmal bone cyst with a literature review. Neurochirurgie 2018; 64: 431-433
• 387 Chawla B, Khurana S, Kashyap S. Giant cell reparative granuloma of the orbit. Ophthalmic Plast Reconstr Surg 2013; 29: e94-95
• 388 Kamoshima Y, Sawamura Y, Imai T. et al. Giant cell tumor of the frontal bone in a girl: case report. Neurol Med Chir (Tokyo) 2011; 51: 798-800
• 389 Smolarz-Wojnowska A, Essig H, Gellrich NC. et al. [Orbital tumours in children and adolescents. Differential diagnostics and clinical symptoms]. Ophthalmologe 2010; 107: 543-548
• 390 Vernet O, Ducrey N, Deruaz JP. et al. Giant cell tumor of the orbit. Neurosurgery 1993; 32: 848-851
• 391 Yip CM, Lee HP, Hsu SS. et al. Left orbital roof giant cell tumor of bone: A case report. Surg Neurol Int 2018; 9: 127
• 392 Yamaguchi T, Dorfman HD. Giant cell reparative granuloma: a comparative clinicopathologic study of lesions in gnathic and extragnathic sites. Int J Surg Pathol 2001; 9: 189-200
• 393 de Lange J, van den Akker HP, van den Berg H. Central giant cell granuloma of the jaw: a review of the literature with emphasis on therapy options. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007; 104: 603-615
• 394 Auclair PL, Cuenin P, Kratochvil FJ. et al. A clinical and histomorphologic comparison of the central giant cell granuloma and the giant cell tumor. Oral Surg Oral Med Oral Pathol 1988; 66: 197-208
• 395 de Lange J, van Rijn RR, van den Berg H. et al. Regression of central giant cell granuloma by a combination of imatinib and interferon: a case report. Br J Oral Maxillofac Surg 2009; 47: 59-61
• 396 Roman-Romero L, Gonzalez-Garcia R. Cholesterol granuloma of the orbit. Report of cases and analysis of controversial treatment. J Maxillofac Oral Surg 2011; 10: 166-169
• 397 Loeffler KU, Kommerell G. Cholesterol granuloma of the orbit--pathogenesis and surgical management. Int Ophthalmol 1997; 21: 93-98
• 398 Selva D, Phipps SE, O'Connell JX. et al. Pathogenesis of orbital cholesterol granuloma. Clin Exp Ophthalmol 2003; 31: 78-82
• 399 Daus W, Voges J, Schwechheimer K. et al. [Cholesterol granuloma of the orbits--clinicopathologic study]. Klin Monbl Augenheilkd 1988; 193: 195-199
• 400 Hsu HT, Liao WC, Wu CC. et al. Cholesterol granuloma of the orbit. Kaohsiung J Med Sci 2017; 33: 422-423
• 401 Rong AJ, Erickson BP, Blessing NW. et al. Orbital cholesterol granuloma: A report and discussion of orbital findings. Am J Ophthalmol Case Rep 2019; 15: 100468
• 402 Arat YO, Chaudhry IA, Boniuk M. Orbitofrontal cholesterol granuloma: distinct diagnostic features and management. Ophthalmic Plast Reconstr Surg 2003; 19: 382-387
• 403 Aferzon M, Millman B, O'Donnell TR. et al. Cholesterol granuloma of the frontal bone. Otolaryngol Head Neck Surg 2002; 127: 578-581
• 404 Kabra R, Patel S, Shanbhag S. Orbital Chondroma: A rare mesenchymal tumor of orbit. Indian J Ophthalmol 2015; 63: 551-554
• 405 Garrity J, Henderson J. Henderson’s Orbital Tumors.In 4th ed. Aufl. USA: Lippincott Williams and Wilkis; 2007: 103–104
• 406 Rootman J, Connell J. Primary bone tumors of orbit. Surv Ophthalmol 2004; 49: 328-342
• 407 Shields J, Bakewell B, Augsburger J. et al. Classification and incidence of space-occupying lesions of the orbit. A survey of 645 biopsies. Arch Ophthalmol 1984; 102: 1606-1611
• 408 Pushker N, Meel R, Sharma S. et al. Giant orbital Schwannoma with fluid-fluid-levels. Br J Ophthalmol 2010; 95: 1168
• 409 Misra S, Gogri P, Misra N. et al. Recurrent neurofibroma of the orbit. Australas Med J 2013; 30: 189-191
• 410 Lee L, Gigantelli J, Kincaid M. Localized neurofibroma of the orbit: a radiographic and histopathologic study. Ophthal Plast Reconstr Surg 2000; 16: 241-246
• 411 Turbin R, Thompson C, Kennerdell J. et al. A long-term visual outcome comparison in patients with optic nerve sheath meningioma managed with observation, surgery, radiotherapy, or surgery and radiotherapy. Ophtalmology 2002; 109: 890-899
• 412 Schittkowski M, Fichter N., Orbitale Neoplasien Teil I. Einführung, vaskuläre und neurogene Neoplasien. Ophthalmologe 2012; 109: 1033-1046
• 413 Jain D, Ebrahimi K, Miller N. et al. Intraorbital meningiomas: a pathologic review using current World Health Organization criteria. Arch Pathol Lab Med 2010; 134: 766-770
• 414 Eddleman C, Liu J. Optic nerve sheath meningioma: current diagnosis and treatment. Neurosurg Focus 2007; 23: E4
• 415 Saeed P, Rootman J, Nugent R. et al. Optic nerve sheath meningiomas. Ophthalmology 2003; 110: 2019-2030
• 416 Ramey W, Arnold S, Chiu A. et al. A Rare Case of Optic Nerve Schwannoma: Case Report and Review of the Literature. Cureus 2015; 7: e265
• 417 Gnekow A. Low-grade chiasmatic-hypothalamic glioma-carboplatin and vincristine chemotherapy effectively defers radiotherapy within a comprehensive treatment strategy - report from the multicenter treatment study for children and adolescents with a low grade glimoa - HIT-LGG 1996 - of the Society of Paediatric Oncology and Hematology (GPOH). Klin Padiatr 2004; 216: 331-342
• 418 Sharif S. Second primary tumors in neurofibromatosis 1 patients treated for optic nerve glioma: substantial risks after radiotherapy. J Clin Oncol 2006; 24: 2570-2575
• 419 Wilhelm H. Primary optic nerve tumors. Curr Opin Neurol 2009; 22: 11-18
• 420 Emesz M, Arlt E, Krall E. et al. Granularzelltumor der Orbita. Der. Ophthalmologe 2014; 111: 866-870
• 421 Huang N, Rayess H, Svider P. et al. Orbital Paraganglioma: A Systematic Review. J Neurol Surg B Skull Base 2017; 79: 407-412
• 422 Makhdoomi R, Nayil K, Santosh V. et al. Orbital paraganglioma--a case report and review of the literature. Clin Neuropathol 2010; 29: 100-104
• 423 Al-Khiary H, Ayoubi A, Elkhamary S. Primary orbital ganglioneuroma in a 2-year-old healthy boy. Saudi J Ophthalmol 2010; 24: 101-104
• 424 Cannon T, Brown H, Hughes B. Orbital Ganglioneuroma in a Patient With Chronic Progressive Proptosis. Arch Ophthalmol 2004; 122: 1712-1714
• 425 Hatsukawa Y, Furukawa A, Kawamura H. et al. Rhabdomyoma of the orbit in a child. Am J Ophthalmol 1997; 123: 142-144
• 426 Li Y, Li N, Zang W. et al. Rhabdomyoma of the orbit. J Pediatr Ophthalmol Strabismus 2008; 45: 113-115
• 427 Myung J, Kim I, Chun J et al. Rhabdomyoma of the orbit: a case report. Pediatric Radiolog. y. 32: 589–592
• 428 Gündüz K, Günalp I, Erden E. et al. Orbital leiomyoma: report of a case and review of the literature. Surv Ophthalmol 2004; 49: 237-242
• 429 Merani R, Khannah G, Mann S. et al. Orbital leiomyoma: a case report with clinical, radiological and pathological correlation. Clin Exp Ophthalmol 2005; 33: 408-411
• 430 Shah N, Chang W, White V. et al. Orbital lipoma: 2 cases and review of literature. Ophthalmic Plast Reconstr Surg 2007; 23: 202-205
• 431 Franchi G, Sleilati E, Soupre V. et al. Melanotic neuroectodermal tumour of infancy involving the orbit and maxilla: surgical management and follow-up strategy. Br J Plast Surg 2002; 55: 526-529
• 432 Koob M, Fayard C, Pariente D. et al. Prenatal diagnosis of orbital melanotic neuroectodermal tumor in infancy. Ultrasound Obstet Gynecol 2015; 46: 247-252
• 433 Soles B, Wilson A, Lucas D. et al. Melanotic Neuroectodermal Tumor of Infancy. Arch Pathol Lab Med 2018; 142: 1358-1363
• 434 NIH. Childhood Rhabdomyosarcoma Treatment (PDQ®)–Health Professional Version. In: National Cancer Institute at the National Institutes of Health; 2020
• 435 Al-Bargi H, Al-Maiman M. Orbital fibrosarcoma: a case report and literature review. Egypt J Oral Maxillofac Surg 2012; 3: 45-48
• 436 Bahrami A, Folpe A. Adult-type fibrosarcoma: A reevaluation of 163 putative cases diagnosed at a single institution over a 48-year period. Am J Surg Pathol 2010; 34: 1504-1513
• 437 Scruggs B, Ho S, Valenzuela A. Diagnostic challenges in primary orbital fibrosarcoma: a case report. Clin Ophthalmol 2014; 8: 2319-2323
• 438 Almater A, Alfaleh A, Alshomar K et al. Retinoblastoma: Update on Current Management, Retinoblastoma - Past, Present and Future. In Alkatan H, Hrsg.Retinoblastoma: IntechOpen; 2019
• 439 Cassoux N, Lumbroso L, Levy-Gabriel C. et al. Retinoblastoma: Update on Current Management. Asia-Pac. J Ophthalmol 2017; 6: 290-295
• 440 WHO. RETINOBLASTOMA - 2014 Review of Cancer Medicines on the WHO List of Essential Medicines. In: Union for International Cancer Control; 2014
• 441 Caignard A, Faguer R, Mercier P. et al. Optic nerve and visual pathways primary glioblastoma treated with radiotherapy and temozolomide chemotherapy. Eur J Ophthalmol 2014; 24: 637-640
• 442 Waheed S, Huang B, Zamora C. Glioblastoma involving the optic nerve. Am J Neuroradiol 2018; 41: e
• 443 Alireza M, Amelot A, Chauvet D. Poor prognosis and challenging treatment of optic nerve malignant gliomas: Literature review and case report series. World Neurosurg 2017; 97: e1-e6
• 444 Ashour O, Stalling M, Ramsey J. et al. Intraocular Medulloepithelioma. RadioGraphics 2018; 38: 194-199
• 445 Verdijk R. On the Classification and Grading of Medulloepithelioma of the Eye. Ocul Oncol Pathol 2016; 2: 190-193
• 446 Hei Y, Kang L, Yang X. Orbital alveolar soft part sarcoma: A report of 8 cases and review of the literature. Oncol Lett 2018; 15: 304-314
• 447 Inci E, Korkut N, Erem M. et al. [Alveolar soft tissue sarcoma]. HNO 2004; 52: 145-149
• 448 Rose A, Kabiru J, Rose G. Alveolar soft-part sarcoma of the orbit. Afr J Paediatr Surg 2011; 8: 82-84
• 449 Dirksen U, Jürgens H. S1-Leitlinie: Ewing-Sarkome des Kindes- und Jugendalters. Stand 06/2014, DOI: AWMF-Register Nr. 025/006
• 450 Kaliki S, Rathi S, Palkonda V. Primary orbital Ewing sarcoma family of tumors: a study of 12 cases. Eye 2018; 32: 615-621
• 451 Chaugule S, Putambekar A, Gavade S. et al. Primary Orbital Leiomyosarcoma in an Adult Male. Ophthal Plast Reconstr Surg 2019; 35: e27-e29
• 452 Klippenstein K, Wesley R, Glick A. Orbital Leiomyosarcoma After Retinoblastoma. Ophthalmic Surg Lasers Imaging. Retina 1999; 30: 579-583
• 453 Yeniad B, Tuncer S, Peksayar G. et al. Primary Orbital Leiomyosarcoma. Ophth. Plast Reconstr Surg 2009; 25: 154-155
• 454 Cai Y, McMenamin E, Geoff R. et al. Primary liposarcoma of the orbit: A clinicopathologic study of seven cases. Ann Diagn Pathol 2001; 5: 255-266
• 455 Garrity J, Henderson J, Cameron J. Henderson's Tumors of Primitive Mesoderm, Striated muscle, Adipose Tissue and Smooth muscle.In Garrity JA HJ, Cameron JD , Hrsg. Henderson's orbital tumors. 4th edition. AuflPhiladelphia: Lippincott Williams and Wilkins; 2007: 123–141
• 456 Alkatan H, Chaudhry I, Al-Qahtani A. Epithelioid sarcoma of the orbit. Ann Saudi Med 2011; 31: 187-189
• 457 Inazawa N, Hatakeyama N, Hori T. et al. Primary orbital neuroblastoma in a 1-month-old boy. Pediatr Int 2014; 56: 122-125
• 458 Vallinayagam M, Rao V, Pandian D. et al. Primary orbital neuroblastoma with intraocular extension. Indian J Ophthalmol 2015; 63: 684-686
• 459 Zhang N, Lin L. Presumed primary orbital neuroblastoma in a 20-month-old female. Ophthal Plast Reconstr Surg 2010; 26: 383-385
• 460 Rose A, Luthert P, Jayasena C. et al. Primary Orbital Melanoma: Presentation, Treatment, and Long-term Outcomes for 13 Patients. Front Oncol 2017; 7: 316
• 461 Kiratli H, Balci K, Güler G. Primary orbital endodermal sinus tumor (yolk sac tumor). J AAPOS 2008; 12: 623-625
• 462 Mogaddam A, Memar B, Aledavood A. et al. Isolated Orbital Endodermal Sinus Tumor. Ophthal Plast Reconstr Surg 2007; 23: 477-479
• 463 Eckardt A, Lemound J, Rana M. et al. Orbital lymphoma: diagnostic approach and treatment outcome. World J Surg Oncol. 2013 DOI: 73
• 464 Olsen T, Heegaard S. Orbitla Lymphoma. Surv Ophthalmol 2019; 64: 45-66
• 465 Sharma T, Kamath M. Diagnosis and Management of Orbital Lymphoma. Ophthalmic Pearls. 2015 DOI: 37-39
• 466 Bidar M, Wilson M, Laquis S. et al. Clinical and imaging characteristics of orbital leukemic tumors. Ophthalmic Plast Reconstr Surg 2007; 23: 87-93
• 467 Hatton M, Rubin P. Chronic Lymphocytic Leukemia of the Orbit. Arch Ophthalmol 2002; 120: 990-991
• 468 Maka E, Lukáts O, Tóth J. et al. Orbital tumour as initial manifestation of acute myeloid leukemia: granulocytic sarcoma: case report. Pathol Oncol Res 2008; 14: 209-211
• 469 Taylor C, Taylor R, Kinsey S. LEUKEMIC INFILTRATION OF THE ORBIT: Report of Three Cases and Literature Review. Pediatr Hematol Oncol 2005; 22: 415-422
• 470 Pausch N, Sterker I, Bauer U. Maligner intraorbitaler Tumor: Primum oder Metastase?. HNO 2016; 64: 262-264
• 471 Schenke T, Lehmann G, Kunze C. et al. Eine abszessverdächtige Raumforderung in der extraokulären Augenmuskulatur. HNO. 2020
• 472 Suarez C, Ferlito A, Lund V. Management of the orbit in malignant sinunasal tumors. Head Neck 2008; 30: 242-250
• 473 Evert K, Kühnel T, Weiß K. et al. Diagnostik und Management von Gefäßanomalien. Der. Pathologe 2019; 40: 422-430
• 474 Müller-Wille R, Wildgruber M, Sadick M. et al. Vascular Anomalies (Part II): Interventional Therapy of Peripheral Vascular Malformations. Fortschr Röntgenstr 2018; 190: 927-937
• 475 Sadick M, Müller-Wille R, Wildgruber M. et al. Vascular Anomalies (Part I): Classification and Diagnostics of Vascular Anomalies. Fortschr Röntgenstr 2018; 190: 825-835
• 476 Wassef M, Blei F, Adams D. et al. Vascular Anomalies Classification: Recommendations From the International Society for the Study of Vascular Anomalies. Pediatrics 2015; 136: e203-e214
• 477 Fay A, Nguyen J, Jakobiec F. et al. Propranolol for Isolated Orbital Infantile Hemangioma. ARCH OPHTHALMOL 2010; 128: 256-258
• 478 Grantzow R, Schmittenbecher P, Höger P. et al. S2k-Leitlinie 006/100: Infantile Hämangiome im Säuglings- und Kleinkindesalter. AWMF online. 2015 DOI: 1-13
• 479 Goldsmith J, van de Rijn M, Syed N. Orbital Hemangiopericytoma and Solitary Fibrous Tumor: A Morphologic Continuum. Internat J Surg Pathol 2001; 9: 295-302
• 480 Pacheco L, Fernandes B, Miyamoto C. et al. Rapid growth of an orbital hemangiopericytoma with atypical histopathological findings. Clin Ophthalmol 2014; 8: 31-33
• 481 Westerfeld C, Allen C, Mihm M. et al. Non-Involuting Congenital Hemangioma Presenting as an Orbital Mass in a Newborn. Investigative Ophthalmology & Visual Science 48: 3582
• 482 Gbolahan O, Fasina O, Adisa A. et al. Spindle cell hemangioma: Unusual presentation of an uncommon tumor. J Oral Maxillofac Pathol 2015; 19: 406
• 483 Budimir I, Demirović A, Iveković R. et al. Epithelioid hemangioma of the orbit: case report. Acta Clin Croat 2015; 54: 92-95
• 484 McEachren T, Brownstein S, Jordan D. et al. Epithelioid hemangioma of the orbit. Ophtalmology 2000; 107: 806-810
• 485 Stiefel H, Ng J, Wilson D. et al. Orbital Cellular Epithelioid Hemangioma. Ocul Oncol Pathol 2019; 5: 424-431
• 486 Kamano H, Noguchi T, Yoshiura T. et al. Intraorbital lobular capillary hemangioma (pyogenic granuloma). Radiat Med 2008; 26: 609-612
• 487 Häußler S, Uecker F, Knopke S. et al. Tufted angiomas of the head and neck. HNO 2018; 66: S1-S6
• 488 Benesch M, Lackner H, Sorantin E. et al. Medikamentöse Therapie vaskulärer Anomalien. Paediatr Paedolog 2020; 55: 21-27
• 489 Cho W, Kim S, Park S. et al. Intracranial kaposiform hemangioendothelioma: proposal of a new malignant variant. J Pediatr Ophthalmol Strabismus 2009; 3: 147-150
• 490 Li B, Li Y, Tian X. et al. Unusual multifocal intraosseous papillary intralymphatic angioendothelioma (Dabska tumor) of facial bones: a case report and review of literature. Diagn Pathol 2013; 8: 160
• 491 Collaco L, Goncalves M, Gomes L. Orbital Kaposi’s Sarcoma in Acquired Immunodeficiency Syndrome. Eur J Ophthalmol 2000; 10: 88-90
• 492 Siddens J, Fishman J, Jackson I. et al. Primary orbital angiosarcoma: a case report. Ophthalmic Plast Reconstr Surg 1999; 15: 454-459
• 493 Lyon D, Tang T, Kidder T. Epithelioid Hemangioendothelioma of the Orbital Bones. Ophtalmology 1992; 99: 1773-1778
• 494 ISSVA. ISSVA Classification of Vascular Anomalies ©2018. In: International Society for the Study of Vascular Anomalies
• 495 Wildgruber M, Sadick M, Muller-Wille R. et al. Vascular tumors in infants and adolescents. Insights Imaging 2019; 10: 30
• 496 Gilbert P, Dubois J, Giroux F. New Treatment Approaches to Arteriovenous Malformations. Semin Intervent Radiol 2017; 34: 258-271
• 497 Schobinger RA, Fontaine R. Periphere Angiodysplasien.