Association Between Metabolic Syndrome and All-Cause Mortality in Patients with Acute Coronary Syndrome: A Meta-Analysis

Yong Yang; Haili Shen; Zhigeng Jin; Dongxing Ma; Qing Zhao; Xuyi Zhang

doi:10.1055/a-1381-8245

Hormone and Metabolic Research, Table of Contents

Horm Metab Res 2021; 53(04): 257-263
DOI: 10.1055/a-1381-8245

Endocrine Care

Association Between Metabolic Syndrome and All-Cause Mortality in Patients with Acute Coronary Syndrome: A Meta-Analysis

Authors

Yong Yang

¹Department of Cardiology, Third Medical Center of PLA General Hospital, Beijing, China
Haili Shen

²Cadre’s Ward, Third Medical Center of PLA General Hospital, Beijing, China
Zhigeng Jin

¹Department of Cardiology, Third Medical Center of PLA General Hospital, Beijing, China
Dongxing Ma

¹Department of Cardiology, Third Medical Center of PLA General Hospital, Beijing, China
Qing Zhao

¹Department of Cardiology, Third Medical Center of PLA General Hospital, Beijing, China
Xuyi Zhang

³Medical Service Department, Third Medical Center of PLA General Hospital, Beijing, China

Abstract

The association between metabolic syndrome (MetS) and survival outcome after acute coronary syndrome (ACS) remains controversial. This meta-analysis sought to examine the association of MetS with all-cause mortality among patients with ACS. Two authors independently searched PubMed and Embase databases (from their inception to June 27, 2020) for studies that examined the association of MetS with all-cause mortality among patients with ACS. Outcome measures were in-hospital mortality and all-cause mortality during the follow-up. A total of 10 studies involving 49 896 ACS patients were identified. Meta-analysis indicated that presence of MetS was associated with an increased risk of long-term all-cause mortality [risk ratio (RR) 1.25; 95% CI 1.15–1.36; n=9 studies] and in-hospital mortality (RR 2.35; 95% CI 1.40–3.95; n=2 studies), respectively. Sensitivity and subgroup analysis demonstrated the credibility of the value of MetS in predicting long-term all-cause mortality. MetS is associated with an increased risk of long-term all-cause mortality among patients with ACS. However, additional studies are required to investigate the association of MetS with in-hospital mortality.

Key words

metabolic syndrome - acute coronary syndrome - in-hospital mortality - all-cause mortality

Full Text

References

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