Hamostaseologie 2021; 41(02): 128-135
DOI: 10.1055/a-1347-6551
Review Article

Effects and Side Effects of Platelet Transfusion

Fabrice Cognasse
1  Etablissement Français du Sang Auvergne-Rhône-Alpes, Saint-Étienne, France
2  SAINBIOSE, INSERM U1059, University of Lyon, Université Jean-Monnet-Saint-Etienne, France, France
,
Kathryn Hally
3  Department of Surgery and Anaesthesia, University of Otago, Wellington, New Zealand
4  Wellington Cardiovascular Research Group, Wellington, New Zealand
5  School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand
,
Sebastien Fauteux-Daniel
1  Etablissement Français du Sang Auvergne-Rhône-Alpes, Saint-Étienne, France
2  SAINBIOSE, INSERM U1059, University of Lyon, Université Jean-Monnet-Saint-Etienne, France, France
,
Marie-Ange Eyraud
1  Etablissement Français du Sang Auvergne-Rhône-Alpes, Saint-Étienne, France
2  SAINBIOSE, INSERM U1059, University of Lyon, Université Jean-Monnet-Saint-Etienne, France, France
,
Charles-Antoine Arthaud
1  Etablissement Français du Sang Auvergne-Rhône-Alpes, Saint-Étienne, France
2  SAINBIOSE, INSERM U1059, University of Lyon, Université Jean-Monnet-Saint-Etienne, France, France
,
Jocelyne Fagan
1  Etablissement Français du Sang Auvergne-Rhône-Alpes, Saint-Étienne, France
2  SAINBIOSE, INSERM U1059, University of Lyon, Université Jean-Monnet-Saint-Etienne, France, France
,
Patrick Mismetti
2  SAINBIOSE, INSERM U1059, University of Lyon, Université Jean-Monnet-Saint-Etienne, France, France
,
Hind Hamzeh-Cognasse
2  SAINBIOSE, INSERM U1059, University of Lyon, Université Jean-Monnet-Saint-Etienne, France, France
,
Sandrine Laradi
1  Etablissement Français du Sang Auvergne-Rhône-Alpes, Saint-Étienne, France
2  SAINBIOSE, INSERM U1059, University of Lyon, Université Jean-Monnet-Saint-Etienne, France, France
,
Olivier Garraud
2  SAINBIOSE, INSERM U1059, University of Lyon, Université Jean-Monnet-Saint-Etienne, France, France
,
Peter Larsen
3  Department of Surgery and Anaesthesia, University of Otago, Wellington, New Zealand
4  Wellington Cardiovascular Research Group, Wellington, New Zealand
5  School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand
› Author Affiliations

Abstract

Aside from their canonical role in hemostasis, it is increasingly recognized that platelets have inflammatory functions and can regulate both adaptive and innate immune responses. The main topic this review aims to cover is the proinflammatory effects and side effects of platelet transfusion. Platelets prepared for transfusion are subject to stress injury upon collection, preparation, and storage. With these types of stress, they undergo morphologic, metabolic, and functional modulations which are likely to induce platelet activation and the release of biological response modifiers (BRMs). As a consequence, platelet concentrates (PCs) accumulate BRMs during processing and storage, and these BRMs are ultimately transfused alongside platelets. It has been shown that BRMs present in PCs can induce immune responses and posttransfusion reactions in the transfusion recipient. Several recent reports within the transfusion literature have investigated the concept of platelets as immune cells. Nevertheless, current and future investigations will face the challenge of encompassing the immunological role of platelets in the scope of transfusion.



Publication History

Received: 15 September 2020

Accepted: 07 January 2021

Publication Date:
12 March 2021 (online)

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