Open Access
CC BY-NC-ND 4.0 · Endosc Int Open 2021; 09(03): E496-E504
DOI: 10.1055/a-1341-0788
Original article

EUS-guided gastroenterostomy versus enteral stenting for gastric outlet obstruction: Systematic review and meta-analysis

Authors

  • Saurabh Chandan

    1   Division of Gastroenterology, CHI Creighton University Medical Center, Omaha, Nebraska, United States
  • Shahab R. Khan

    2   Section of Gastroenterology, Rush University Medical Center, Chicago, Illinois, USA.
  • Babu P. Mohan

    3   Division of Gastroenterology and Hepatology, University of Utah School of Medicine, Salt Lake City, Utah, United States
  • Aun R. Shah

    4   Gastroenterology and Hepatology, University of Nebraska Medical Center, Omaha, Nebraska, Unites States
  • Mohammad Bilal

    5   Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States
  • Daryl Ramai

    6   Internal Medicine, The Brooklyn Hospital Center, New York, United States
  • Neil Bhogal

    4   Gastroenterology and Hepatology, University of Nebraska Medical Center, Omaha, Nebraska, Unites States
  • Banreet Dhindsa

    4   Gastroenterology and Hepatology, University of Nebraska Medical Center, Omaha, Nebraska, Unites States
  • Lena L. Kassab

    7   Internal Medicine, Mayo Clinic, Rochester, Minnesota, United States
  • Shailendra Singh

    8   Department of Medicine, West Virginia University Charleston Division, Charleston, West Virginia, United States
  • Suresh Ponnada

    9   Internal Medicine, Carilion Roanoke Memorial Hospital, Roanoke, Virginia, United States
  • Andrew K. Nguyen

    3   Division of Gastroenterology and Hepatology, University of Utah School of Medicine, Salt Lake City, Utah, United States
  • Stephanie McDonough

    3   Division of Gastroenterology and Hepatology, University of Utah School of Medicine, Salt Lake City, Utah, United States
  • Douglas G. Adler

    3   Division of Gastroenterology and Hepatology, University of Utah School of Medicine, Salt Lake City, Utah, United States
Preview

Abtract

Background and study aims Endoscopic and surgical techniques have been utilized for palliation of gastric outlet obstruction (GOO). Enteral stenting (ES) is an established technique with high clinical success and low morbidity rate. Endoscopic ultrasound-guided gastroenterostomy (EUS-GE) is a novel approach that aims to provide sustained palliation of GOO. We conducted a comprehensive review and meta-analysis to evaluate the effectiveness in terms of clinical and technical success, as well as the safety profile of EUS-GE and ES.

Methods We searched multiple databases from inception through July 2020 to identify studies that reported on safety and effectiveness of EUS-GE in comparison to ES. Pooled rates of technical success, clinical success, and adverse events (AEs) were calculated. Study heterogeneity was assessed using I2% and 95 % confidence interval.

Results Five studies including 659 patients were included in our final analysis. Pooled rate of technical and clinical success for EUS-GE was 95.2 % (CI 87.2-.98.3, I2 = 42) and 93.3 % (CI 84.4–97.3, I2 = 59) while for ES it was 96.9 % (CI 90.9–99, I2 = 64) and 85.6 % (CI 73–92.9, I2 = 85), respectively. Pooled rate of re-intervention was significantly lower with EUS-GE i. e. 4 % (CI 1.8–8.7, I2 = 35) compared to ES, where it was 23.6 % (CI 17.5–31, I2 = 35), p = 0.001. Pooled rates of overall and major AEs were comparable between the two techniques.

Conclusion EUS-GE is comparable in terms of technical and clinical effectiveness and has a similar safety profile when compared to ES for palliation of GOO.

Supplementary material



Publication History

Received: 18 September 2020

Accepted: 27 November 2020

Article published online:
22 February 2021

© 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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