Cerebral Venous Thrombosis: What's New?

Abstract

Thrombosis of the cerebral veins and sinuses (CVT) is a distinct cerebrovascular disorder that, unlike arterial stroke, most often affects children and young adults, especially women. In this review, we will summarize recent advances on the knowledge of patients with CVT.

Keywords

cerebral venous thrombosis - brain lesion - recanalization - risk factor - anticoagulation

Publikationsverlauf

Eingereicht: 24. September 2020

Angenommen: 07. Dezember 2020

Artikel online veröffentlicht:
15. Februar 2021

• References

• 1 Ferro JM, Canhão P, Stam J, Bousser MG, Barinagarrementeria F. ISCVT Investigators. Prognosis of cerebral vein and dural sinus thrombosis: results of the International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT). Stroke 2004; 35 (03) 664-670
• 2 Dentali F, Poli D, Scoditti U. et al; CErebral VEin Thrombosis International Study Investigators. Long-term outcomes of patients with cerebral vein thrombosis: a multicenter study. J Thromb Haemost 2012; 10 (07) 1297-1302
• 3 Ferro JM, Canhão P, Bousser MG, Stam J, Barinagarrementeria F. ISCVT Investigators. Cerebral vein and dural sinus thrombosis in elderly patients. Stroke 2005; 36 (09) 1927-1932
• 4 Zuurbier SM, Hiltunen S, Lindgren E. et al. Cerebral venous thrombosis in older patients. Stroke 2018; 49 (01) 197-200
• 5 Coutinho JM, Zuurbier SM, Aramideh M, Stam J. The incidence of cerebral venous thrombosis: a cross-sectional study. Stroke 2012; 43 (12) 3375-3377
• 6 Otite FO, Patel S, Sharma R. et al. Trends in incidence and epidemiologic characteristics of cerebral venous thrombosis in the United States. Neurology 2020; 95 (16) e2200-e2213
• 7 Ferro JM, Canhão P, Aguiar de Sousa D. Cerebral venous thrombosis. Presse Med 2016; 45 (12, Pt 2): e429-e450
• 8 Ferro JM, Canhão P, Bousser M-G, Stam J, Barinagarrementeria F, Stolz E. ISCVT Investigators. Cerebral venous thrombosis with nonhemorrhagic lesions: clinical correlates and prognosis. Cerebrovasc Dis 2010; 29 (05) 440-445
• 9 Coutinho JM, van den Berg R, Zuurbier SM. et al. Small juxtacortical hemorrhages in cerebral venous thrombosis. Ann Neurol 2014; 75 (06) 908-916
• 10 Aguiar de Sousa D, Lucas Neto L, Jung S. et al. Brush sign is associated with increased severity in cerebral venous thrombosis. Stroke 2019; 50 (06) 1574-1577
• 11 Aguiar de Sousa D, Lucas Neto L, Arauz A. et al. Early recanalization in patients with cerebral venous thrombosis treated with anticoagulation. Stroke 2020; 51 (04) 1174-1181
• 12 Silvis SM, de Sousa DA, Ferro JM, Coutinho JM. Cerebral venous thrombosis. Nat Rev Neurol 2017; 13 (09) 555-565
• 13 Amoozegar F, Ronksley PE, Sauve R, Menon BK. Hormonal contraceptives and cerebral venous thrombosis risk: a systematic review and meta-analysis. Front Neurol 2015; 6: 7
• 14 Martinelli I, Sacchi E, Landi G, Taioli E, Duca F, Mannucci PM. High risk of cerebral-vein thrombosis in carriers of a prothrombin-gene mutation and in users of oral contraceptives. N Engl J Med 1998; 338 (25) 1793-1797
• 15 Zuurbier SM, Arnold M, Middeldorp S. et al. Risk of cerebral venous thrombosis in obese women. JAMA Neurol 2016; 73 (05) 579-584
• 16 Pomp ER, Lenselink AM, Rosendaal FR, Doggen CJM. Pregnancy, the postpartum period and prothrombotic defects: risk of venous thrombosis in the MEGA study. J Thromb Haemost 2008; 6 (04) 632-637
• 17 Sultan AA, West J, Tata LJ, Fleming KM, Nelson-Piercy C, Grainge MJ. Risk of first venous thromboembolism in and around pregnancy: a population-based cohort study. Br J Haematol 2012; 156 (03) 366-373
• 18 Ferro JM, de Sousa DA, Oliveira S. Cerebral venous thrombosis: genetic aspects. In: Stroke Genetics. 2nd ed.. Springer Link; 2017: 295-326
• 19 Coutinho JM, Zuurbier SM, Gaartman AE. et al. Association between anemia and cerebral venous thrombosis: case-control study. Stroke 2015; 46 (10) 2735-2740
• 20 Cavalcanti DD, Raz E, Shapiro M. et al. Cerebral venous thrombosis associated with COVID-19. AJNR Am J Neuroradiol 2020; 41 (08) 1370-1376
• 21 Baldini T, Asioli GM, Romoli M. et al. Cerebral venous thrombosis and SARS-CoV-2 infection: a systematic review and meta-analysis. Eur J Neurol 2021;
• 22 Marjot T, Yadav S, Hasan N, Bentley P, Sharma P. Genes associated with adult cerebral venous thrombosis. Stroke 2011; 42 (04) 913-918
• 23 Shlebak A. Antiphospholipid syndrome presenting as cerebral venous sinus thrombosis: a case series and a review. J Clin Pathol 2016; 69 (04) 337-343
• 24 Silvis SM, Hiltunen S, Lindgren E. et al. Cancer and risk of cerebral venous thrombosis: a case-control study. J Thromb Haemost 2018; 16 (01) 90-95
• 25 Zuurbier SM, Lauw MN, Coutinho JM. et al. Clinical course of cerebral venous thrombosis in adult acute lymphoblastic leukemia. J Stroke Cerebrovasc Dis 2015; 24 (07) 1679-1684
• 26 Passamonti SM, Biguzzi E, Cazzola M. et al. The JAK2 V617F mutation in patients with cerebral venous thrombosis. J Thromb Haemost 2012; 10 (06) 998-1003
• 27 Aguiar de Sousa D, Mestre T, Ferro JM. Cerebral venous thrombosis in Behçet's disease: a systematic review. J Neurol 2011; 258 (05) 719-727
• 28 Netteland DF, Mejlænder-Evjensvold M, Skaga NO, Sandset EC, Aarhus M, Helseth E. Cerebral venous thrombosis in traumatic brain injury: a cause of secondary insults and added mortality. J Neurosurg 2020; ; (epub ahead of print)
• 29 Benjamin CG, Sen RD, Golfinos JG. et al. Postoperative cerebral venous sinus thrombosis in the setting of surgery adjacent to the major dural venous sinuses. J Neurosurg 2018; ;(October): 1-7
• 30 Zuurbier SM, Coutinho JM, Stam J. et al; ISCVT Investigators. Clinical outcome of anticoagulant treatment in head or neck infection-associated cerebral venous thrombosis. Stroke 2016; 47 (05) 1271-1277
• 31 Aguiar de Sousa D, Lucas Neto L, Canhão P, Ferro JM. Recanalization in cerebral venous thrombosis. Stroke 2018; 49 (08) 1828-1835
• 32 Ferro JM, Bousser MG, Canhão P. et al; European Stroke Organization. European Stroke Organization guideline for the diagnosis and treatment of cerebral venous thrombosis - endorsed by the European Academy of Neurology. Eur J Neurol 2017; 24 (10) 1203-1213
• 33 Misra UK, Kalita J, Chandra S, Kumar B, Bansal V. Low molecular weight heparin versus unfractionated heparin in cerebral venous sinus thrombosis: a randomized controlled trial. Eur J Neurol 2012; 19 (07) 1030-1036
• 34 Afshari D, Moradian N, Nasiri F, Razazian N, Bostani A, Sariaslani P. The efficacy and safety of low-molecular-weight heparin and unfractionated heparin in the treatment of cerebral venous sinus thrombosis. Neurosciences (Riyadh) 2015; 20 (04) 357-361
• 35 Qureshi A, Perera A. Low molecular weight heparin versus unfractionated heparin in the management of cerebral venous thrombosis: a systematic review and meta-analysis. Ann Med Surg (Lond) 2017; 17: 22-26
• 36 Coutinho JM, Ferro JM, Canhão P, Barinagarrementeria F, Bousser MG, Stam J. ISCVT Investigators. Unfractionated or low-molecular weight heparin for the treatment of cerebral venous thrombosis. Stroke 2010; 41 (11) 2575-2580
• 37 Ilyas A, Chen CJ, Raper DM. et al. Endovascular mechanical thrombectomy for cerebral venous sinus thrombosis: a systematic review. J Neurointerv Surg 2017; 9 (11) 1086-1092
• 38 Lewis W, Saber H, Sadeghi M, Rajah G, Narayanan S. Transvenous endovascular recanalization for cerebral venous thrombosis: a systematic review and meta-analysis. World Neurosurg 2019; 130: 341-350
• 39 Siddiqui FM, Weber MW, Dandapat S. et al. Endovascular thrombolysis or thrombectomy for cerebral venous thrombosis: study of nationwide inpatient sample 2004-2014. J Stroke Cerebrovasc Dis 2019; 28 (06) 1440-1447
• 40 Coutinho JM, Zuurbier SM, Bousser MG. et al; TO-ACT Investigators. Effect of Endovascular treatment with medical management vs standard care on severe cerebral venous thrombosis: the TO-ACT randomized clinical trial. JAMA Neurol 2020; 77 (08) 966-973
• 41 Canhão P, Ferro JM, Lindgren AG, Bousser MG, Stam J, Barinagarrementeria F. ISCVT Investigators. Causes and predictors of death in cerebral venous thrombosis. Stroke 2005; 36 (08) 1720-1725
• 42 Ferro JM, Crassard I, Coutinho JM. et al; Second International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT 2) Investigators. Decompressive surgery in cerebrovenous thrombosis: a multicenter registry and a systematic review of individual patient data. Stroke 2011; 42 (10) 2825-2831
• 43 Zuurbier SM, Coutinho JM, Majoie CBLM, Coert BA, van den Munckhof P, Stam J. Decompressive hemicraniectomy in severe cerebral venous thrombosis: a prospective case series. J Neurol 2012; 259 (06) 1099-1105
• 44 Raza E, Shamim MS, Wadiwala MF, Ahmed B, Kamal AK. Decompressive surgery for malignant cerebral venous sinus thrombosis: a retrospective case series from Pakistan and comparative literature review. J Stroke Cerebrovasc Dis 2014; 23 (01) e13-e22
• 45 Lindgren E, Silvis SM, Hiltunen S. et al. Acute symptomatic seizures in cerebral venous thrombosis. Neurology 2020; 95 (12) e1706-e1715
• 46 Sánchez van Kammen M, Lindgren E, Silvis SM. et al. Late seizures in cerebral venous thrombosis. Neurology 2020; 95 (12) e1716-e1723
• 47 Ferro JM, Coutinho JM, Dentali F. et al; RE-SPECT CVT Study Group. Safety and efficacy of dabigatran etexilate vs dose-adjusted warfarin in patients with cerebral venous thrombosis: a randomized clinical trial. JAMA Neurol 2019; 76 (12) 1457-1465
• 48 Miranda B, Ferro JM, Canhão P. et al; ISCVT Investigators. Venous thromboembolic events after cerebral vein thrombosis. Stroke 2010; 41 (09) 1901-1906
• 49 Palazzo P, Agius P, Ingrand P. et al. Venous thrombotic recurrence after cerebral venous thrombosis: a long-term follow-up study. Stroke 2017; 48 (02) 321-326
• 50 Martinelli I, Bucciarelli P, Passamonti SM, Battaglioli T, Previtali E, Mannucci PM. Long-term evaluation of the risk of recurrence after cerebral sinus-venous thrombosis. Circulation 2010; 121 (25) 2740-2746
• 51 Lim HY, Ng C, Donnan G, Nandurkar H, Ho P. Ten years of cerebral venous thrombosis: male gender and myeloproliferative neoplasm is associated with thrombotic recurrence in unprovoked events. J Thromb Thrombolysis 2016; 42 (03) 423-431
• 52 Pires GS, Ribeiro DD, Oliveira JAQ. et al. Risk factors associated with recurrent venous thromboembolism after a first cerebral venous thrombosis event: a cohort study. Thromb Res 2019; 178: 85-90
• 53 Miranda B, Aaron S, Arauz A. et al. The benefit of EXtending oral antiCOAgulation treatment (EXCOA) after acute cerebral vein thrombosis (CVT): EXCOA-CVT cluster randomized trial protocol. Int J Stroke 2018; 13 (07) 771-774
• 54 Aguiar de Sousa D, Canhão P, Crassard I. et al; ISCVT-2-PREGNANCY Investigators. Safety of pregnancy after cerebral venous thrombosis results of the ISCVT (international study on cerebral vein and dural sinus thrombosis)-2 PREGNANCY study. Stroke 2017; 48 (11) 3130-3133
• 55 Aguiar de Sousa D, Canhão P, Ferro JM. Safety of pregnancy after cerebral venous thrombosis: a systematic review. Stroke 2016; 47 (03) 713-718
• 56 Aguiar de Sousa D, Canhão P, Ferro JM. Safety of pregnancy after cerebral venous thrombosis: systematic review update. J Neurol 2018; 265 (01) 211-212
• 57 Kowoll CM, Kaminski J, Weiß V. et al. Severe cerebral venous and sinus thrombosis: clinical course, imaging correlates, and prognosis. Neurocrit Care 2016; 25 (03) 392-399
• 58 Soyer B, Rusca M, Lukaszewicz AC. et al. Outcome of a cohort of severe cerebral venous thrombosis in intensive care. Ann Intensive Care 2016; 6 (01) 29
• 59 Zuurbier SM, Hiltunen S, Tatlisumak T. et al. Admission hyperglycemia and clinical outcome in cerebral venous thrombosis. Stroke 2016; 47 (02) 390-396
• 60 Hiltunen S, Putaala J, Haapaniemi E, Tatlisumak T. Long-term outcome after cerebral venous thrombosis: analysis of functional and vocational outcome, residual symptoms, and adverse events in 161 patients. J Neurol 2016; 263 (03) 477-484