Festination und Freezing bei Parkinsonsyndromen untersuchen

Die Störung der Gangrhythmik bis hin zum völligen Versagen der Ganginitiierung ist ein typisches Symptom von Parkinsonerkrankungen. Erkennen und phänomenologisch korrektes Beschreiben stellen einen wichtigen Baustein der syndromalen Differentialdiagnose dar. Da Festination und Freezing relevant zum Verlust an Lebensqualität beitragen und bedeutende Sturzauslöser sind, kommt der Untersuchung eine klinisch wichtige Rolle bei der Versorgung betroffener Parkinsonpatienten zu.

• Literatur

• 1 Nutt JG, Bloem BR, Giladi N. et al. Freezing of gait: moving forward on a mysterious clinical phenomenon. Lancet Neurol 2011; 10: 734-744
• 2 Nieuwboer A, Giladi N. Characterizing freezing of gait in Parkinson’s disease: Models of an episodic phenomenon. Mov Disord 2013; 28: 1509-1519
• 3 Schaafsma JD, Balash Y, Gurevich T. et al. Characterization of freezing of gait subtypes and the response of each to levodopa in Parkinson’s disease. Eur J Neurol 2003; 10: 391-398
• 4 Nonnekes J, Giladi N, Guha A. et al. Gait festination in parkinsonism: introduction of two phenotypes. J Neurol 2019; 266: 426-430
• 5 Ziegler K, Schroeteler F, Ceballos-Baumann AO. et al. A new rating instrument to assess festination and freezing gait in Parkinsonian patients. Mov Disord 2010; 25: 1012-1018
• 6 Charcot J-M. Lectures on the diseases of the nervous system. On paralysis agitans (lecture V). London: New Sydenham Society; 1877: 129-156
• 7 Fahn S. The freezing phenomenon in parkinsonism. Adv Neurol 1995; 67: 53-63
• 8 Giladi N, Shabtai H, Simon ES. et al. Construction of freezing of gait questionnaire for patients with Parkinsonism. Parkinsonism Relat Disord 2000; 6: 165-170
• 9 Fasano A, Herzog J, Seifert E. et al. Modulation of gait coordination by subthalamic stimulation improves freezing of gait. Mov Disord 2011; 26: 844-851
• 10 Plotnik M, Giladi N, Balash Y. et al. Is freezing of gait in Parkinson’s disease related to asymmetric motor function?. Ann Neurol 2005; 57: 656-663
• 11 Fietzek UM, Zwosta J, Schroeteler FE. et al. Levodopa changes the severity of freezing in Parkinson’s disease. Parkinsonism Relat Disord 2013; 19: 894-896
• 12 Espay AJ, Fasano A, van Nuenen BFL. et al. “On” state freezing of gait in Parkinson disease: a paradoxical levodopa-induced complication. Neurology 2012; 78: 454-457
• 13 Fasano A, Herzog J, Seifert E. et al. Modulation of gait coordination by subthalamic stimulation improves freezing of gait. Mov Disord 2011; 26: 844-851
• 14 Höglinger GU, Respondek G, Stamelou M. et al. Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria. Mov Disord 2017; 32: 853-864
• 15 Thanvi B, Lo N, Robinson T. Vascular parkinsonism--an important cause of parkinsonism in older people. Age Ageing 2005; 34: 114-119
• 16 Vizcarra JA, Lang AE, Sethi KD. et al. Vascular parkinsonism: deconstructing a syndrome. Mov Disord 2015; 30: 886-894
• 17 Seuthe J, Kuball K, Hoffmann A-K. et al. Validation of the German Version of the New Freezing of Gait Questionnaire for People with Parkinson’s Disease. Park Dis 2021; 2021: 8841679
• 18 Giladi N, Shabtai H, Simon ES. Construction of freezing of gait questionnaire for patients with Parkinsonism. Parkinsonism Relat Disord 2000; 6: 165-170
• 19 Vogler A, Janssens J, Nyffeler T. et al. German translation and validation of the “freezing of gait questionnaire” in patients with Parkinson’s disease. Park Dis 2015; 2015: 982058
• 20 Snijders AH, Takakusaki K, Debu B. et al. Physiology of freezing of gait. Ann Neurol 2016; 80: 644-659
• 21 Fietzek UM, Stuhlinger L, Plate A. et al. Spatial constraints evoke increased number of steps during turning in Parkinson’s disease. Clin Neurophysiol Off J Int Fed Clin Neurophysiol 2017; 128: 1954-1960
• 22 Ambani LM, Van Woert MH. Start hesitation--a side effect of long-term levodopa therapy. N Engl J Med 1973; 288: 1113-1115
• 23 Fling BW, Cohen RG, Mancini M. et al. Asymmetric pedunculopontine network connectivity in parkinsonian patients with freezing of gait. Brain J Neurol 2013; 136 : 2405-2418
• 24 Ehgoetz Martens KA, Shine JM. et al. Evidence for subtypes of freezing of gait in Parkinson’s disease. Mov Disord Off J Mov Disord Soc 2018; 33: 1174-1178
• 25 Goetz CG, Tilley BC, Shaftman SR. et al. Movement Disorder Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing results. Mov Disord Off J Mov Disord Soc 2008; 23: 2129-2170