Abstract
Introduction Intrahepatic cholestasis of pregnancy (ICP) is associated with an increased risk
of adverse pregnancy outcomes in mothers and infants. The aim was to evaluate the
sensitivity and specificity of biochemical detection of ICP by ROC curve and to determine
the threshold of more reliable experimental indicators.
Materials and Methods 305 patients and 305 healthy pregnant women were enrolled in the study.
Results The average levels of TBA, ALT, and AST in the ICP group were much higher than those
in the control group (P<0. 001); the area of both CG and TBA under ROC curve was up
to 0.99, the sensitivity was 97.7%, and the specificity was 99.3%.
Conclusions This study did not find any single specificity and sensitivity markers that could
be used to reliably diagnose ICP. In the future, we will pay more attention to the
correlation between sensitive biochemical indicators and adverse pregnancy outcomes.
Keywords
intrahepatic cholestasis of pregnancy - diagnostics - roc curve