Planta Med
DOI: 10.1055/a-1266-6980
Reviews

Antibacterial Compounds from Mushrooms: A Lead to Fight ESKAPEE Pathogenic Bacteria?

Violette Hamers
Faculté de pharmacie, Université de Strasbourg, CNRS, IPHC UMR 7178, CAMBAP, Strasbourg, France
,
Clément Huguet
Faculté de pharmacie, Université de Strasbourg, CNRS, IPHC UMR 7178, CAMBAP, Strasbourg, France
,
Mélanie Bourjot
Faculté de pharmacie, Université de Strasbourg, CNRS, IPHC UMR 7178, CAMBAP, Strasbourg, France
,
Faculté de pharmacie, Université de Strasbourg, CNRS, IPHC UMR 7178, CAMBAP, Strasbourg, France
› Author Affiliations

Abstract

Infectious diseases are among the greatest threats to global health in the 21st century, and one critical concern is due to antibiotic resistance developed by an increasing number of bacterial strains. New resistance mechanisms are emerging with many infections becoming more and more difficult if not impossible to treat. This growing phenomenon not only is associated with increased mortality but also with longer hospital stays and higher medical costs. For these reasons, there is an urgent need to find new antibiotics targeting pathogenic microorganisms such as ESKAPEE bacteria. Most of currently approved antibiotics are derived from microorganisms, but higher fungi could constitute an alternative and remarkable reservoir of anti-infectious compounds. For instance, pleuromutilins constitute the first class of antibiotics derived from mushrooms. However, macromycetes still represent a largely unexplored source. Publications reporting the antibacterial potential of mushroom extracts are emerging, but few purified compounds have been evaluated for their bioactivity on pathogenic bacterial strains. Therefore, the aim of this review is to compile up-to-date data about natural products isolated from fruiting body fungi, which significantly inhibit the growth of ESKAPEE pathogenic bacteria. When available, data regarding modes of action and cytotoxicity, mandatory when considering a possible drug development, have been discussed in order to highlight the most promising compounds.

Supporting Information



Publication History

Received: 20 July 2020

Accepted after revision: 18 September 2020

Publication Date:
15 October 2020 (online)

© 2020. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany