Planta Med 2021; 87(01/02): 49-70
DOI: 10.1055/a-1257-8402
Biological and Pharmacological Activities
Reviews

Anticancer Potential of Compounds from the Brazilian Blue Amazon

Diego V. Wilke
1  Núcleo de Pesquisa e Desenvolvimento de Medicamentos (NPDM), Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, CE, Brazil
,
Paula C. Jimenez
2  Departamento de Ciências do Mar, Instituto do Mar, Universidade Federal de São Paulo, Santos, SP, Brazil
,
Paola C. Branco
3  Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SP, Brazil
,
Paula Rezende-Teixeira
3  Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SP, Brazil
,
Amaro E. Trindade-Silva
1  Núcleo de Pesquisa e Desenvolvimento de Medicamentos (NPDM), Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, CE, Brazil
,
Anelize Bauermeister
3  Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SP, Brazil
,
4  Núcleo de Pesquisa em Produtos Naturais e Sintéticos (NPPNS), Departamento de Ciências Biomoleculares, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil
,
3  Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SP, Brazil
› Author Affiliations
Supported by: ArboControl Brasil Project FNS/UnB TED74/2016 and TED42/2017
Supported by: Fundação de Amparo à Pesquisa do Estado de São Paulo 2014/50926-0
Supported by: Fundação de Amparo à Pesquisa do Estado de São Paulo 2015/17177-6
Supported by: Fundação de Amparo à Pesquisa do Estado de São Paulo 2017/09022-8
Supported by: Fundação de Amparo à Pesquisa do Estado de São Paulo 2017/17646-4
Supported by: Conselho Nacional de Desenvolvimento Científico e Tecnológico 465637/2014-0

Abstract

“Blue Amazon” is used to designate the Brazilian Economic Exclusive Zone, which covers an area comparable in size to that of its green counterpart. Indeed, Brazil flaunts a coastline spanning 8000 km through tropical and temperate regions and hosting part of the organisms accredited for the countryʼs megadiversity status. Still, biodiversity may be expressed at different scales of organization; besides species inventory, genetic characteristics of living beings and metabolic expression of their genes meet some of these other layers. These metabolites produced by terrestrial creatures traditionally and lately added to by those from marine organisms are recognized for their pharmaceutical value, since over 50% of small molecule-based medicines are related to natural products. Nonetheless, Brazil gives a modest contribution to the field of pharmacology and even less when considering marine pharmacology, which still lacks comprehensive in-depth assessments toward the bioactivity of marine compounds so far. Therefore, this review examined the last 40 years of Brazilian natural products research, focusing on molecules that evidenced anticancer potential–which represents ~ 15% of marine natural products isolated from Brazilian species. This review discusses the most promising compounds isolated from sponges, cnidarians, ascidians, and microbes in terms of their molecular targets and mechanisms of action. Wrapping up, the review delivers an outlook on the challenges that stand against developing groundbreaking natural products research in Brazil and on a means of surpassing these matters.



Publication History

Received: 16 June 2020

Accepted after revision: 01 September 2020

Publication Date:
03 November 2020 (online)

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