Literaturübersicht zur Therapie der CNO mit TNF-α-Inhibitoren

Die optimale Therapie der Chronisch Nichtbakteriellen Osteomyelitis (CNO) ist zum jetzigen Zeitpunkt nicht geklärt. Neben NSAR werden kurzfristig Glukokortikoide, konventionelle Basismedikamente (Disease Modifying Antirheumatic Drugs: kDMARDs), Bisphosphonate und Biologika eingesetzt. Die vorliegende Arbeit thematisiert diesen differenzialtherapeutischen Aspekt mit Schwerpunkt auf den Tumornekrosefaktor-α-Inhibitoren (TNF-i).

Publikationsverlauf

Artikel online veröffentlicht:
26. Februar 2021

• Literatur

• 1 Aktay Ayaz N, Topaloglu R, Özaltin F. et al A case of chronic recurrent multifocal osteomyelitis successfully treated with etanercept. Pediatric Rheumatology 2008; 6: P191
• 2 Andreasen CM, Jurik AG, Deleuran BW. et al 2020. ‘Pamidronate in chronic non-bacterial osteomyelitis: a randomized, double-blinded, placebo-controlled pilot trial’, Scand J Rheumatol 2020; 49: 312-322
• 3 Beck C, Morbach H, Beer M. et al Chronic nonbacterial osteomyelitis in childhood: prospective follow-up during the first year of anti-inflammatory treatment. Arthritis Res Ther 2010; 12 (02) R74: 1-11
• 4 Borzutzky A, Stern S, Reiff A. et al Pediatric chronic nonbacterial osteomyelitis. Pediatrics 2012; 130: e1190-1197
• 5 Carpenter E, Jackson MA, Friesen CA. et al Crohn’s-associated chronic recurrent multifocal osteomyelitis responsive to infliximab. J Pediatr 2004; 144: 541-544
• 6 Deutschmann A, Mache CJ, Bodo K. et al Successful treatment of chronic recurrent multifocal osteomyelitis with tumor necrosis factor-alpha blockage. Pediatrics 2005; 116: 1231-1233
• 7 Eisenstein EM, Syverson GD, Vora SS, Williams CB. Combination therapy with methotrexate and etanercept for refractory chronic recurrent multifocal osteomyelitis. J Rheumatol 2011; 38 (04) 782-783
• 8 Eleftheriou D, Gerschman T, Sebire N. et al Biologic therapy in refractory chronic non-bacterial osteomyelitis of childhood. Rheumatology (Oxford) 2010; 49: 1505-1512
• 9 Girschick H, Finetti M, Orlando F. et al Organisation Paediatric Rheumatology International Trials, and registry the Eurofever. The multifaceted presentation of chronic recurrent multifocal osteomyelitis: a series of 486 cases from the Eurofever international registry. Rheumatology (Oxford) 2018; 57: 1504
• 10 Hedrich CM, Morbach H, Reiser C, Girschick HJ. New Insights into Adult and Paediatric Chronic Non-bacterial Osteomyelitis CNO. Curr Rheumatol Rep 2020; 22: 52
• 11 Hedrich CM, Girschick HJ. Chronic non-bacterial osteomyelitis. In: Textbook of Autoinflammation. Cham, Switzerland: Springer Nature Switzerland; 2019
• 12 Hofmann SR, Schnabel A, Rosen-Wolff A. et al 2016. ‘Chronic Nonbacterial Osteomyelitis: Pathophysiological Concepts and Current Treatment Strategies. J Rheumatol 2016; 43: 1956-1964
• 13 Hospach T, Langendoerfer M, von Kalle T. et al Spinal involvement in chronic recurrent multifocal osteomyelitis (CRMO) in childhood and effect of pamidronate. Eur J Pediatr 2010; 169: 1105-1111
• 14 Jansson A, Renner ED, Ramser J. et al Classification of non-bacterial osteitis: retrospective study of clinical, immunological and genetic aspects in 89 patients. Rheumatology (Oxford) 2007; 46: 154-160
• 15 Jansson A, Borte M, Hospach A. et al Diagnostik und Therapie der nichtbakteriellen Osteomyelitis. Monatsschr Kinderheilkd 2014; 162: 539-545
• 16 Kaiser D, Bolt I, Hofer M. et al Chronic nonbacterial osteomyelitis in children: a retrospective multicenter study. Pediatr Rheumatol Online J 2015; 13: 25
• 17 Kerrison C, Davidson JE, Cleary AG, Beresford MW. Pamidronate in the treatment of childhood SAPHO syndrome. Rheumatology (Oxford) 2004; 43: 1246-1251
• 18 Pastore S, Ferrara G, Monasta L. et al Chronic nonbacterial osteomyelitis may be associated with renal disease and bisphosphonates are a good option for the majority of patients. Acta Paediatr 2016; 105: e328-e333
• 19 Roderick MR, R.Shah R, Rogers V. et al Chronic recurrent multifocal osteomyelitis (CRMO) – advancing the diagnosis. Pediatr Rheumatol Online J 2016; 14: 47
• 20 Schnabel A, Range U, Hahn G. et al Treatment Response and Longterm Outcomes in Children with Chronic Nonbacterial Osteomyelitis. J Rheumatol 2017; 44: 1058-1065
• 21 Schwarz T, Petzke S, Morbach H. et al Juvenile chronic non-bacterial osteomyelitis (CNO): Long term course of disease and response to treatment in a large institutional cohort. Pediatric Rheumatology 2015; 13: P178
• 22 Schwarz T, Oommen P, Windschall D. et al Protokolle zur Klassifikation, Überwachung und Therapie der chronisch nichtbakteriellen Osteomyelitis. Arthritis und Rheuma 2018; 4: 282-288
• 23 Tlougan BE, Podjasek JO, O’Haver J. et al Chronic recurrent multifocal osteomyelitis (CRMO) and synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome with associated neutrophilic dermatoses: a report of seven cases and review of the literature. Pediatr Dermatol 2009; 26: 497-505
• 24 Wipff J, Costantino F, Lemelle I. et al A large national cohort of French patients with chronic recurrent multifocal osteitis’. Arthritis Rheumatol 2015; 67: 1128-1137
• 25 Wolber C, David-Jelinek K, Udvardi A. et al [Successful therapy of sacroiliitis in SAPHO syndrome by etanercept]. Wien Med Wochenschr 2011; 161: 204-208
• 26 Zhao Y, Chauvin NA, Jaramillo D, Burnham JM. Aggressive Therapy Reduces Disease Activity without Skeletal Damage Progression in Chronic Nonbacterial Osteomyelitis. J Rheumatol 2015; 42: 1245-1251
• 27 Zhao Y, Wu EY, Oliver MS. et al Group Chronic Nonbacterial Osteomyelitis/Chronic Recurrent Multifocal Osteomyelitis Study, Arthritis the Childhood, Vasculitis Autoinflammatory Rheumatology Research Alliance Scleroderma, and Subcommittee Rare Diseases. Consensus Treatment Plans for Chronic Nonbacterial Osteomyelitis Refractory to Nonsteroidal Antiinflammatory Drugs and/or With Active Spinal Lesions. Arthritis Care Res (Hoboken) 2018; 70: 1228-1237
• 28 Ziobrowska-Bech A, Fiirgaard B, Heuck C. et al Ten-year review of Danish children with chronic non-bacterial osteitis. Clin Exp Rheumatol 2013; 31: 974-979