Exp Clin Endocrinol Diabetes 2021; 129(03): 224-233
DOI: 10.1055/a-1247-4713
Article

Multicenter, Observational Study of Lanreotide Autogel for the Treatment of Patients with Acromegaly in Routine Clinical Practice in Germany, Austria and Switzerland

Sylvère Störmann
1   Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, München, Germany
,
Jochen Schopohl
1   Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, München, Germany
,
Catharina Bullmann
2   Amedes VZ, Hamburg
,
Christoph Terkamp
3   Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover
,
Mirjam Christ-Crain
4   Clinic of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel
,
Reinhard Finke
5   Medical practice at the Kaisereiche (üBAG), Berlin
,
Jörg Flitsch
6   Department of Neurosurgery, University Hospital Hamburg-Eppendorf, Hamburg
,
Ilonka Kreitschmann-Andermahr
7   Department of Neurosurgery and Spine Surgery, University Medicine Essen, University of Duisburg-Essen, Essen, Germany
,
Anton Luger
8   Division of Endocrinology and Metabolism, Medical University of Vienna, Vienna
,
Günter Stalla
1   Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, München, Germany
9   MEDICOVER Neuroendocrinology MVZ, Munich
,
Aude Houchard
10   Ipsen, Boulogne-Billancourt Cedex
,
Dorit Helbig
11   Ipsen Pharma GmbH, Ettlingen
,
Stephan Petersenn
12   ENDOC Center for Endocrine Tumors, Hamburg
› Author Affiliations

Abstract

Background Evidence from controlled trials has shown that lanreotide autogel is effective in achieving biochemical and symptom control in patients with acromegaly. However, it is important to better understand the real-world patient population receiving lanreotide autogel treatment.

Methods In this non-interventional study the long-term treatment response to lanreotide autogel in adult patients with acromegaly from office-based centers or clinics in Germany, Austria and Switzerland was studied. Assessments included growth hormone and insulin-like growth factor-I levels, symptoms, quality of life, lanreotide plasma levels and tumor somatostatin receptor subtype expression. The primary endpoint was achievement of full biochemical control, defined as growth hormone ≤2.5 µg/L and insulin-like growth factor I normalization at month 12.

Results 76 patients were enrolled from 21 sites. 7/51 (13.7%) patients of the efficacy population had full biochemical control at baseline, 15/33 (45.5%) at month 12 and 10/26 (38.5%) at month 24 of treatment. At 12 months of treatment higher rates of biochemical control were observed in the following subgroups: older patients (>53 years [median]), females, treatment-naïve patients, and patients with a time since diagnosis of longer than 1.4 years (median). No clinically relevant differences in acromegaly symptoms or quality of life scores were observed. Median fasting blood glucose and glycated hemoglobin levels remained unchanged throughout the study. No new safety signals were observed. Overall tolerability of treatment with lanreotide autogel was judged by 80.8% of the enrolled patients at month 12 as ‘very good’ or ‘good’.

Conclusion Treatment with lanreotide autogel in a real-world setting showed long-term effectiveness and good tolerability in patients with acromegaly.



Publication History

Received: 29 April 2020
Received: 31 July 2020

Accepted: 25 August 2020

Article published online:
07 December 2020

© 2020. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
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