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Drug Res (Stuttg) 2021; 71(03): 115-121
DOI: 10.1055/a-1238-2639
Review

Recent Advancement of Synthesis of Isatins as a Versatile Pharmacophore: A review

Gajendra Kumar 
1   Department of Chemistry, Krishna College, Bijnor (UP), India
,
Netra Pal Singh
2   Department of Chemistry, Deen Dayal Upadhyaya Gorakhpur University, Gorakhpur (UP), India
,
Kaushal Kumar
3   Department of Chemistry, Meerut College, Meerut (UP), India
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Abstract

Isatin (1 H-indole-2, 3-Dione) and its derivatives are versatile compounds which acts as a precursor for a large number of pharmacologically active compounds. Therefore isatins have a significant importance in the synthesis of different heterocyclic compounds. Isatins show variety of biological activities. In this review we focus on synthetic methods of isatins and their biological activities such as antimicrobial, anticonvulsant, anti-inflammatory and analgesic activity, antitubercular activity.

Key words

anti-inflammatory drugs - adverse drug reactions - pharmacology


Publication History

Received: 19 July 2020

Accepted: 03 August 2020

Article published online:
09 December 2020

© 2020. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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