Z Geburtshilfe Neonatol 2021; 225(03): 238-243
DOI: 10.1055/a-1233-9084
Original Article

The Role of Melatonin, IL-8 and IL-10 in Intrahepatic Cholestasis of Pregnancy

Samettin Çelik
1  Obstetrics and Gynecology, Samsun Education and Research Hospital, Samsun, Turkey
,
Huri Guve
2  Department of Obstetrics and Gynecology, Düzce Üniversitesi Tip Fakültesi, Duzce, Turkey
,
Canan Çalışkan
1  Obstetrics and Gynecology, Samsun Education and Research Hospital, Samsun, Turkey
,
Sebahattin Çelik
3  Obstetrics and Gynecology, Balıkesir Devlet Hastanesi, Balıkesir, Turkey
› Author Affiliations

Abstract

Introduction Intrahepatic cholestasis of pregnancy is a pregnancy-specific liver disease that usually emerges during the third trimester of pregnancy. It is characterized by itching and elevated serum total bile acid levels, and it may lead to severe fetal complications. This study aimed to investigate the role of interleukin-8, a pro-inflammatory cytokine; interleukin-10, an anti-inflammatory cytokine; and melatonin in intrahepatic cholestasis of pregnancy.

Materials and Methods This prospective, case-controlled study was conducted with 51 women with intrahepatic cholestasis of pregnancy (40 mild and 11 severe cases) and 43 healthy pregnant women. Serum interleukin-8, interleukin-10, and melatonin levels were evaluated.

Results Melatonin and interleukin -10 were significantly lower in subjects with intrahepatic cholestasis of pregnancy (p=0.001; p=0.001, respectively p<0.05). Interleukin-8 levels were found to be significantly higher in the cholestasis group than control group (p=0.001, p<0.05).

Conclusions Because interleukin-8, interleukin-10, and melatonin were found to be significantly correlated with intrahepatic cholestasis of pregnancy, we believe this finding could shed light on the etiology of the disease.



Publication History

Received: 17 May 2020

Accepted after revision: 24 July 2020

Publication Date:
17 September 2020 (online)

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