Int J Sports Med
DOI: 10.1055/a-1231-5410
Genetics & Molecular Biology

Biomarkers and Redox Balance in Aging Rats after Dynamic and Isometric Resistance Training

Rodrigo Vanerson Passos Neves
1  Graduate Program in Physical Education, Catholic University of Brasília, Brasília, Brazil
,
1  Graduate Program in Physical Education, Catholic University of Brasília, Brasília, Brazil
,
Hugo Luca Corrêa
1  Graduate Program in Physical Education, Catholic University of Brasília, Brasília, Brazil
,
Kethelen Mariana da Silva Aires
1  Graduate Program in Physical Education, Catholic University of Brasília, Brasília, Brazil
,
1  Graduate Program in Physical Education, Catholic University of Brasília, Brasília, Brazil
,
Michel Kendy Sousa
2  Nephrology Division, Department of Medicine, Federal University of São Paulo, São Paulo, Brazil
,
Whitley Jo Stone
3  School of Nutrition, Kinesiology, and Physiological Sciences, University of Central Missouri, Warrensburg, MO, United States
,
Lana Ribeiro Aguiar
4  Graduate Program in Genomic Science and Biotechnology, Catholic University of Brasília, Brasília, Brazil
,
Jonato Prestes
1  Graduate Program in Physical Education, Catholic University of Brasília, Brasília, Brazil
,
1  Graduate Program in Physical Education, Catholic University of Brasília, Brasília, Brazil
,
Rosângela Vieira Andrade
4  Graduate Program in Genomic Science and Biotechnology, Catholic University of Brasília, Brasília, Brazil
,
Milton Rocha Moraes
1  Graduate Program in Physical Education, Catholic University of Brasília, Brasília, Brazil
› Author Affiliations
Funding: This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES) – Finance Code 001.

Abstract

Aging muscle is prone to sarcopenia and its associated telomere shortening and increased oxidative stress. Telomeres are protected by a shelterin protein complex, proteins expressed in response to DNA damage. Aerobic exercise training has shown to positively modulate these proteins while aging, but the effects of resistance training are less clear. This investigation was to examine the role of dynamic and isometric RT on markers of senescence and muscle apoptosis: checkpoint kinase 2, 53 kDa protein, shelterin telomere repeat binding 1 and 2, DNA repair, telomere length and redox state in the quadriceps muscle. Fifteen 49-week-old male rats were divided into three groups: control, dynamic resistance training, and isometric resistance training. Dynamic and isometric groups completed five sessions per week during 16 weeks at low to moderate intensity (20–70% maximal load). Only dynamic group decreased expression of 53 kDa protein, proteins from shelterin complex, oxidative stress, and improved antioxidant defense. There was no difference among groups regarding telomere length. In conclusion, dynamic resistance training was more effective than isometric in reducing markers of aging and muscle apoptosis in elderly rats. This modality should be considered as valuable tool do counteract the deleterious effects of aging.



Publication History

Received: 05 May 2020

Accepted: 17 July 2020

Publication Date:
18 September 2020 (online)

© 2020. Thieme. All rights reserved.

© Georg Thieme Verlag KG
Stuttgart · New York