Reaction Kinetics Modeling of eHsp70 Induced by Norepinephrine in Response to Exercise Stress

Attila Lovas; Brigitta Szilágyi; Edit Bosnyák; Pongrácz Ács; András Oláh; Zsolt Komka; Miklós Tóth; Béla Merkely; Endre Németh; Beatrix Gilányi; Miklós Krepuska; Csaba Sőti; Péter Sótonyi

doi:10.1055/a-1224-3792

International Journal of Sports Medicine, Inhaltsverzeichnis

Int J Sports Med 2021; 42(06): 506-512
DOI: 10.1055/a-1224-3792

Training & Testing

Reaction Kinetics Modeling of eHsp70 Induced by Norepinephrine in Response to Exercise Stress

Attila Lovas

¹Institute of Mathematics, Budapest University of Technology and Economics, Budapest, Hungary

,

Brigitta Szilágyi

¹Institute of Mathematics, Budapest University of Technology and Economics, Budapest, Hungary

,

Edit Bosnyák

²Department of Health Sciences and Sport Medicine, University of Physical Education, Budapest, Hungary

,

Pongrácz Ács

³Faculty of Health Sciences, University of Pecs, Pecs, Hungary

,

András Oláh

³Faculty of Health Sciences, University of Pecs, Pecs, Hungary

,

Zsolt Komka

²Department of Health Sciences and Sport Medicine, University of Physical Education, Budapest, Hungary

⁸Pázmány Péter Catholic University, Faculty of Information Technology and Bionics, Budapest

,

Miklós Tóth

²Department of Health Sciences and Sport Medicine, University of Physical Education, Budapest, Hungary

,

Béla Merkely

⁴Department of Cardiology, Heart and Vascular Center, FIFA Medical Centre of Excellence, Semmelweis University Budapest, Hungary

,

Endre Németh

⁵Department of Combat Sports, University of Physical Education, Budapest, Hungary

,

Beatrix Gilányi

⁶Institute of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary

,

Miklós Krepuska

⁷Department of Vascular Surgery, Heart and Vascular Center, Semmelweis University, Budapest, Hungary

⁸Pázmány Péter Catholic University, Faculty of Information Technology and Bionics, Budapest

,

Csaba Sőti

⁶Institute of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary

,

Péter Sótonyi

⁷Department of Vascular Surgery, Heart and Vascular Center, Semmelweis University, Budapest, Hungary

› Institutsangaben

Abstract

Exercise elicits a systemic adaptation reaction, involving both neuroendocrine and cellular/paracrine stress responses, exemplified by the sympathoadrenergic activity and the release of cellular Hsp70 into the circulation. Regular sports training is known to result in increased fitness. In this study, we characterized the plasma norepinephrine and Hsp70 levels and modeled their relationship in response to exercise stress by bicycle ergometer in 12 trained judoka athletes and in 10 healthy controls. Resting norepinephrine was similar in both groups, whereas Hsp70 was significantly higher in controls compared to athletes. Intense exercise load induced both norepinephrine and Hsp70 elevation. However, both norepinephrine and Hsp70 were significantly lower in athletes compared to the control group. A reaction kinetic model was developed that provided a quantitative description of norepinephrine-facilitated extracellular Hsp70 release, congruent with the experimental data. Our study indicates that exercise-induced norepinephrine and extracellular Hsp70 may be coordinated responses to physiological stress, which are robustly affected by regular sports activity.

Key words

reaction kinetics modeling - norepinephrine - Hsp70 - exercise stress

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Referenzen

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