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Exp Clin Endocrinol Diabetes 2022; 130(01): 43-48
DOI: 10.1055/a-1221-9618
Article

The TUDID Study – Background and Design of a Prospective Cohort

Benjamin Assad Jaghutriz
1   Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany
2   German Center for Diabetes Research (DZD e.V.), Tübingen, Germany
3   Department of Internal Medicine, Division of Endocrinology, Diabetology, and Nephrology, University Hospital Tübingen, Tübingen, Germany
,
Robert Wagner
1   Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany
2   German Center for Diabetes Research (DZD e.V.), Tübingen, Germany
3   Department of Internal Medicine, Division of Endocrinology, Diabetology, and Nephrology, University Hospital Tübingen, Tübingen, Germany
,
Stephanie Kullmann
1   Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany
2   German Center for Diabetes Research (DZD e.V.), Tübingen, Germany
5   Institute of Medical Psychology and Behavioral Neurobiology/fMEG Center, Eberhard Karls University Tübingen, Tübingen, Germany
,
Louise Fritsche
1   Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany
2   German Center for Diabetes Research (DZD e.V.), Tübingen, Germany
,
Sabine S. Eckstein
1   Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany
2   German Center for Diabetes Research (DZD e.V.), Tübingen, Germany
,
Corinna Dannecker
1   Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany
2   German Center for Diabetes Research (DZD e.V.), Tübingen, Germany
,
Caroline Willmann
2   German Center for Diabetes Research (DZD e.V.), Tübingen, Germany
3   Department of Internal Medicine, Division of Endocrinology, Diabetology, and Nephrology, University Hospital Tübingen, Tübingen, Germany
,
Elko Randrianarisoa
1   Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany
2   German Center for Diabetes Research (DZD e.V.), Tübingen, Germany
,
Angela Lehn-Stefan
1   Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany
2   German Center for Diabetes Research (DZD e.V.), Tübingen, Germany
,
Anja Hieronimus
2   German Center for Diabetes Research (DZD e.V.), Tübingen, Germany
3   Department of Internal Medicine, Division of Endocrinology, Diabetology, and Nephrology, University Hospital Tübingen, Tübingen, Germany
,
Sarah Hudak
1   Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany
2   German Center for Diabetes Research (DZD e.V.), Tübingen, Germany
3   Department of Internal Medicine, Division of Endocrinology, Diabetology, and Nephrology, University Hospital Tübingen, Tübingen, Germany
,
Dorothea Vosseler
2   German Center for Diabetes Research (DZD e.V.), Tübingen, Germany
3   Department of Internal Medicine, Division of Endocrinology, Diabetology, and Nephrology, University Hospital Tübingen, Tübingen, Germany
,
Apostolia Lamprinou
1   Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany
2   German Center for Diabetes Research (DZD e.V.), Tübingen, Germany
3   Department of Internal Medicine, Division of Endocrinology, Diabetology, and Nephrology, University Hospital Tübingen, Tübingen, Germany
,
Philipp Huber
3   Department of Internal Medicine, Division of Endocrinology, Diabetology, and Nephrology, University Hospital Tübingen, Tübingen, Germany
,
Andreas Vosseler
1   Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany
2   German Center for Diabetes Research (DZD e.V.), Tübingen, Germany
3   Department of Internal Medicine, Division of Endocrinology, Diabetology, and Nephrology, University Hospital Tübingen, Tübingen, Germany
,
Gabriel Willmann
6   University Eye Hospital Tübingen, Tübingen, Germany
,
Nils Heyne
3   Department of Internal Medicine, Division of Endocrinology, Diabetology, and Nephrology, University Hospital Tübingen, Tübingen, Germany
,
Diana Wolff
7   Department of Conservative Dentistry, University Hospital Tübingen, Tübingen, Germany
,
Norbert Stefan
1   Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany
2   German Center for Diabetes Research (DZD e.V.), Tübingen, Germany
3   Department of Internal Medicine, Division of Endocrinology, Diabetology, and Nephrology, University Hospital Tübingen, Tübingen, Germany
,
Hans-Ulrich Häring
1   Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany
2   German Center for Diabetes Research (DZD e.V.), Tübingen, Germany
3   Department of Internal Medicine, Division of Endocrinology, Diabetology, and Nephrology, University Hospital Tübingen, Tübingen, Germany
,
Andreas L. Birkenfeld
1   Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany
2   German Center for Diabetes Research (DZD e.V.), Tübingen, Germany
3   Department of Internal Medicine, Division of Endocrinology, Diabetology, and Nephrology, University Hospital Tübingen, Tübingen, Germany
,
Andreas Peter
1   Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany
2   German Center for Diabetes Research (DZD e.V.), Tübingen, Germany
4   Institute for Clinical Chemistry and Pathobiochemistry, Department for Diagnostic Laboratory Medicine, University Hospital Tübingen, Tübingen, Germany
,
Andreas Fritsche 
1   Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany
2   German Center for Diabetes Research (DZD e.V.), Tübingen, Germany
3   Department of Internal Medicine, Division of Endocrinology, Diabetology, and Nephrology, University Hospital Tübingen, Tübingen, Germany
,
Martin Heni 
1   Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany
2   German Center for Diabetes Research (DZD e.V.), Tübingen, Germany
3   Department of Internal Medicine, Division of Endocrinology, Diabetology, and Nephrology, University Hospital Tübingen, Tübingen, Germany
4   Institute for Clinical Chemistry and Pathobiochemistry, Department for Diagnostic Laboratory Medicine, University Hospital Tübingen, Tübingen, Germany
› Author Affiliations Funding: This study was partly supported by a grant (01GI0925) from the Federal Ministry of Education and Research (BMBF) to the German Center for Diabetes Research (DZD e.V.). We acknowledge support by the Deutsche Forschungsgemeinschaft and the Open Access Publishing Fund of the University of Tübingen.
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Abstract

Prevalence of both type 1 and type 2 diabetes mellitus is growing worldwide and one major cause for morbidity and mortality. However, not every patient develops diabetes-related complications, but causes for the individual susceptibility are still not fully understood. As a platform to address this, we initiated the TUDID (TUebingen DIabetes Database) study, a prospective, monocentric, observational study that includes adults with diabetes mellitus who are treated in the inpatient clinic of a University Hospital in southern Germany. Besides a thorough clinical examination and extensive laboratory tests (with integrated biobanking), major study focuses are the kidneys, the eyes, the vasculature as well as cognition and mood where standardized investigations for early stages for diabetes complications are performed. Analyses of the data generated by this precise characterization of diabetes-related complications will contribute to our understanding of the development and course of such complications, and thus facilitate the implementation of tailored treatment options that can reduce the risk and severity of diabetes-related complications.

Key words

diabetes complications - observational - prospective


Publication History

Received: 15 May 2020
Received: 03 July 2020

Accepted: 17 July 2020

Article published online:
10 September 2020

© 2020. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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