Z Geburtshilfe Neonatol 2021; 225(02): 155-160
DOI: 10.1055/a-1209-3861
Original Article

Experience with Real-Time Continuous Glucose Monitoring in Newborns with Congenital Hyperinsulinemic Hypoglycemia

Ayşe Anık
1  Pediatrics, Division of Neonatology, Adnan Menderes University School of Medicine, Aydin, Turkey
,
Münevver Kaynak Türkmen
1  Pediatrics, Division of Neonatology, Adnan Menderes University School of Medicine, Aydin, Turkey
,
Abdullah Barış Akcan
1  Pediatrics, Division of Neonatology, Adnan Menderes University School of Medicine, Aydin, Turkey
,
Tolga Ünüvar
2  Pediatrics, Division of Pediatric Endocrinology, Adnan Menderes University School of Medicine, Aydin, Turkey
,
Sercan Öztürk
3  Pediatrics, Celal Bayar University School of Medicine, Manisa, Turkey
,
Ahmet Anık
2  Pediatrics, Division of Pediatric Endocrinology, Adnan Menderes University School of Medicine, Aydin, Turkey
› Author Affiliations

Abstract

Background Effective treatment and close monitoring of hypoglycemia in children with congenital hyperinsulinemic hypoglycemia (CHH) is vital to prevent brain damage. The current use of capillary sampling schedules does not provide a comprehensive assessment of glycemic status and fails to detect asymptomatic hypoglycemia episodes.

Aim To investigate the efficacy and accuracy of a real-time continuous glucose monitoring system (RT-CGMS) in neonates with CHH.

Methods A sensor connected to RT-CGMS was inserted into the newborn patients and maintained for at least 6 days during their stay in the hospital. We compared the readings of CGMS with capillary blood glucose values using Bland-Altman analysis.

Results A total of 110 blood glucose values were compared to readings from the CGMS. All results were calculated and plotted for CGMS values at 0–4, 5–9, 10–14, 15–19, 20–24, and 25–29 min after capillary blood glucose sampling. CGMS readings were highly correlated with blood glucose values, especially during normoglycemia. In case of hypoglycemia, the mean difference between the CGMS and capillary glucose values was higher. Although the false positive rate for hypoglycemia was relatively high in CGMS, RT-CGMS may show some episodes of hypoglycemia earlier than blood measurement.

Conclusion RT-CGMS is accurate during normoglycemia, and it can reduce the number of capillary blood samples in children with CHH.



Publication History

Received: 22 May 2020

Accepted after revision: 18 June 2020

Publication Date:
03 August 2020 (online)

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