Correlation Between Serum TSH Levels Within Normal Range and Serum Lipid Profile

Abstract

The aim of the work was to investigate the correlation between serum TSH (thyrotropin) levels within normal range and serum lipids. A total of 1962 subjects with normal thyroid function were enrolled. The subjects were divided into four groups according to the quartiles of serum normal TSH levels, [Q₁ (0.27–1.68) mIU/l, Q₂ (1.69–2.35) mIU/l, Q₃ (2.36–3.07) mIU/l, and Q₄ (3.08–4.20) mIU/l]. The effect of serum normal TSH levels on serum lipid profiles of different age or gender was analyzed. The total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) levels of the Q₃ group and TG levels of the Q₄ group were higher than those of the Q₁ group in youth (p <0.05). The TC levels of the Q₃ group were higher than those of the Q₂ group in middle age (p <0.05). The LDL-C levels of middle age or elderly were higher than those of youth at the same TSH levels (p <0.05), while the TC levels of middle age were higher than those of youth in Q₁, Q₃, or Q₄ group (p <0.05), and the TC and HDL-C levels of elderly were higher than those of youth in the Q₂ group (p <0.05). The TG levels of the Q₃ group were higher than those of Q₁ group in males (p <0.05). The LDL-C levels of the Q₃ group were higher than those of the Q₁ group in females (p <0.05). In conclusion, the normal serum TSH levels were found to be closely related to serum lipid profiles, and with increasing TSH levels, serum lipids levels increased gradually.

Key words

thyroid - thyroid-stimulating hormone - serum lipids

Publikationsverlauf

Eingereicht: 29. März 2020

Angenommen nach Revision: 28. Mai 2020

Artikel online veröffentlicht:
23. Juni 2020

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