Paraneoplastische reaktiv perforierende Kollagenose nach transienter akantholytischer Dermatose Grover

Zusammenfassung

Wir berichten über einen 90-jährigen Patienten mit Prostata-Karzinom, bei dem initial ein Morbus Grover bestand, welcher einen Wandel der klinischen Morphe hin zu einer erworbenen reaktiv perforierenden Kollagenose im Kontext eines paraneoplastischen Geschehens zeigte. Die detaillierte Pathogenese der transienten akantholytischen Dermatose Grover sowie der reaktiv perforierenden Kollagenose ist derzeit unklar. Während die reaktiv perforierende Kollagenose sporadisch in den paraneoplastischen Kontext gerückt wird, ist der Morbus Grover bisher nicht als paraneoplastische Erscheinung eingeordnet worden. Wir diskutieren die klinischen und histologischen differenzialdiagnostischen Überlegungen und empfehlen auf Basis dieser Beobachtungen bei Auftreten eines auffälligen Morbus Grover an fakultative Paraneoplasien zu denken.

Abstract

We report on a 90-year-old patient with prostate carcinoma who initially had Groverʼs disease, which showed a clinical change to an acquired reactive perforating collagenosis in the context of a paraneoplastic event. Detailed pathogenesis of the transient acantholytic dermatosis Grover and the reactive perforating collagenosis is currently unclear. While reactive perforating collagenosis is sporadically placed in the paraneoplastic context, Groverʼs disease has not yet been classified as a paraneoplastic phenomenon. We discuss clinical and histological differential diagnostic considerations and, based on these observations, recommend that facultative paraneoplasia should be considered if an unusual Groverʼs disease occurs.

Publication History

Article published online:
05 August 2020

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