Maternal Serum Haptoglobin Levels as a Marker of Preterm Premature Rupture of Membranes

Gul Nihal Buyuk; Z.Asli Oskovi-Kaplan; Huseyin Durukan

doi:10.1055/a-1167-4512

Zeitschrift für Geburtshilfe und Neonatologie, Inhaltsverzeichnis

Z Geburtshilfe Neonatol 2021; 225(01): 47-50
DOI: 10.1055/a-1167-4512

Original Article

Maternal Serum Haptoglobin Levels as a Marker of Preterm Premature Rupture of Membranes

Authors

Gul Nihal Buyuk

¹Obstetrics and Gynecology, Ministry of Health, Ankara City Hospital, Ankara, Turkey
Z.Asli Oskovi-Kaplan

¹Obstetrics and Gynecology, Ministry of Health, Ankara City Hospital, Ankara, Turkey
Huseyin Durukan

²Obstetrics and Gynecology, Mersin University, Mersin, Turkey

Abstract

Objective We aimed to investigate the prognostic value of maternal serum haptoglobin levels in patients presenting with preterm premature rupture of fetal membranes (PPROM) during the second and the third trimesters of pregnancy.

Methods In this case control study, 60 patients were recruited (30 pregnant women with PPROM between 26–34 weeks of gestation and 30 healthy, gestational-age-matched pregnant women without PPROM). White blood cell count (WBC), interleukin 6 (IL-6), C-reactive protein (CRP), sedimentation rate, and haptoglobin levels were measured.

Results The mean age, gestational week, gravida, and parity of the 2 groups were statistically comparable (P>0.001). There was a statistically significant difference between the 2 groups in terms of haptoglobin values (p<0.001). The mean haptoglobin level was 115.5+33.1(mg/dl) in the PPROM group and 66.5+42.6 (mg/dl) in the control group. ROC curve analysis was performed to determine whether the level of haptoglobin alone could diagnose PPROM as an independent marker. It was shown that the level of 94.5 mg/dL for haptoglobin could indicate the diagnosis of PPROM with 80% sensitivity and specificity

Conclusion Maternal serum haptoglobin levels may be a diagnostic marker for suspected PPROM cases when membrane rupture diagnosis is not accurate based on physical examination and other diagnostic tests.

Key words

Preterm premature rupture of fetal membranes - Haptoglobin - Preterm birth - acute phase reactants

Volltext

Referenzen

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