Horm Metab Res 2020; 52(07): 485-491
DOI: 10.1055/a-1160-9902
Review

The Effects of Vitamin D on Metabolic Profiles in Women with Polycystic Ovary Syndrome: A Systematic Review

Ashley Williams
1  Department of Nutrition, Dietetics, and Hospitality Management, Auburn University, AL, USA
,
Jeganathan Ramesh Babu
1  Department of Nutrition, Dietetics, and Hospitality Management, Auburn University, AL, USA
2  Boshell Metabolic Diseases and Diabetes Program, Auburn University, Auburn, AL, USA
,
Danielle D. Wadsworth
3  School of Kinesiology, Auburn University, Auburn, AL, USA
,
Donna Burnett
1  Department of Nutrition, Dietetics, and Hospitality Management, Auburn University, AL, USA
,
Thangiah Geetha
1  Department of Nutrition, Dietetics, and Hospitality Management, Auburn University, AL, USA
2  Boshell Metabolic Diseases and Diabetes Program, Auburn University, Auburn, AL, USA
› Author Affiliations

Abstract

This systematic review aims to evaluate all epidemiological evidence in the literature linking the effect of vitamin D supplementation to metabolic and hormonal functions in women with polycystic ovary syndrome. The literature search was performed with two databases, namely Medline/PubMed and Web of Science, until 20 May 2019 for both observational and experimental studies concerning relationships between vitamin D and polycystic ovary syndrome. A total of ten studies with randomized, double-blinded, and placebo-controlled trial design from 2008 to 2019 were selected for this review. The inclusion criteria were women 18–45 years of age with polycystic ovary syndrome and comparing the metabolic or endocrine parameters between placebo and vitamin D supplementation groups. A total of ten studies were selected for this review. We found that vitamin D supplementation had a significant effect on insulin metabolism, total serum testosterone, hirsutism, C-reactive protein, and total antioxidant capacity in women with polycystic ovary syndrome. Evidence from available randomized controlled trials suggests that patients with polycystic ovary syndrome should take vitamin D supplementation for the beneficial effect of metabolic profiles. However, future research is needed regarding the beneficial effects in women who are non-obese with polycystic ovary syndrome, as well as more studies with larger sample sizes.



Publication History

Received: 25 March 2020

Accepted: 09 April 2020

Publication Date:
18 May 2020 (online)

© Georg Thieme Verlag KG
Stuttgart · New York