CC BY-NC-ND 4.0 · Planta Medica International Open 2020; 07(02): e68-e72
DOI: 10.1055/a-1156-4229
Original Papers

Antioxidant, Cytotoxic, and Acetylcholinesterase Inhibitory Activities of Withanolides from Datura quercifolia

Christian Jasso
1  Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán, México
,
Antonio Nieto-Camacho
1  Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán, México
,
MaríaTeresa Ramírez-Apan
1  Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán, México
,
Mahinda Martínez
2  Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Querétaro, México
,
Emma Maldonado
1  Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán, México
› Author Affiliations

Abstract

Five withanolides identified as daturalactone (1) , withanicandrin (2), withanolide B (3), nicandrin B (4), and daturalactone 2 (5) were isolated from the aerial parts (flowers, leaves, and stems) of Datura quercifolia Kunth. Their structures were determined by analysis of the IR, MS, 1D and 2D NMR spectra. All the isolates were evaluated for their cytotoxic and antioxidant activities, as well as for their capacity to inhibit the activity of the acetylcholinesterase enzyme (AChE). As result, the five withanolides showed weak cytotoxic and pro-oxidant activities, however, they displayed a relevant inhibitory activity against AChE, as indicated by the IC50 values ranging from 1.51 to 12.11 µM. The differences in AChE inhibition seem to be related to the functional group at C-12.

Supporting Information



Publication History

Received: 26 November 2019
Received: 21 February 2020

Accepted: 03 April 2020

Publication Date:
07 May 2020 (online)

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