[177Lu]Lu-DOTA-zoledronate therapy – first application in a patient with primary osseous metastatic bronchial carcinoma
Radioligand therapies are gaining increasing importance in tumor therapy. With bone-seeking radiopharmaceuticals that selectively accumulate in osteoblastic active areas, such as the beta-emiting radionuclides samarium-153 and strontium-89 or the alpha-emitting radium-223, therapy options exist to palliate cancer-induced bone pain   or even prolong survival . [153Sm]Sm-EDTMP is approved for osteoblastic bone metastases regardless of the primary tumor, whereas [89Sr]Sr-Chlorid is only approved for palliative pain therapy for bone metastases of prostate cancer  . Zoledronic acid conjugated to the macrocyclic chelator DOTA and labeled with lutetium-177 ([177Lu]Lu-DOTA-ZOL) represent a new class of promising radiopharmaceuticals for the treatment of bone metastases. The bisphosphonate derivative DOTA-ZOL can also be labeled with gallium-68 for diagnosis using positron emission tomography (PET) . Zoledronic acid, a highly potent new generation bisphosphonate, inhibits bone resorption by the osteoclasts and accumulates in osteoblastic bone. Furthermore, lutetium-177 seems to have superior properties for treatment of bone metastases compared to other radioisotopes  .
We report about a lung cancer patient with osseous metastases, refractory to guideline treatment, who received radioligand therapy with [177Lu]Lu-DOTA-ZOL.
28 April 2020 (online)
© Georg Thieme Verlag KG
Stuttgart · New York
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