CC BY-NC-ND 4.0 · Planta Medica International Open 2020; 07(02): e58-e67
DOI: 10.1055/a-1142-7072
Original Papers

Evaluation of Anti-inflammatory, Anti-pyretic, Analgesic, and Hepatoprotective Properties of Terminalia macroptera

Mahamane Haïdara
1  UMR 152 PHARMA-DEV, Université de Toulouse, IRD, UPS, France
2  Faculté de Pharmacie, Université des Sciences, des Techniques et des Technologies, Bamako, Mali
,
Adama Dénou
2  Faculté de Pharmacie, Université des Sciences, des Techniques et des Technologies, Bamako, Mali
,
1  UMR 152 PHARMA-DEV, Université de Toulouse, IRD, UPS, France
,
Aïssata Camara
1  UMR 152 PHARMA-DEV, Université de Toulouse, IRD, UPS, France
3  Institute for Research and Development of Medicinal and Food Plants of Guinea (IRDPMAG), Dubréka, Guinea
,
Korotoumou Traoré
4  Aidemet ONG, Bamako, Mali
,
Agnès Aubouy
1  UMR 152 PHARMA-DEV, Université de Toulouse, IRD, UPS, France
,
Geneviève Bourdy
1  UMR 152 PHARMA-DEV, Université de Toulouse, IRD, UPS, France
,
Rokia Sanogo
2  Faculté de Pharmacie, Université des Sciences, des Techniques et des Technologies, Bamako, Mali
5  Département de Médecine Traditionnelle (DMT), Institut National de Recherche en Santé Publique (INRSP), Bamako, Mali
› Author Affiliations

Abstract

In Mali, improved traditional medicines [“Médicaments Traditionnels Améliorés”] are prepared from traditionally used medicinal plants. Recently, the Department of Traditional Medicine has identified Terminalia macroptera Guill. & Perr. (Combretaceae) as a potential candidate for an improved traditional medicine. T. macroptera is a West African medicinal plant used in Mali against various health disorders, with more than 30 different indications mentioned by traditional healers, including hepatitis, gonorrhea, fever, pain relief, and various infectious diseases (Helicobacter pylori-associated diseases). To date, validation of most of the biological activities of has been mainly carried out in vitro, except for antimalarial activities. In this study, the potential anti-inflammatory, antipyretic, analgesic, and hepatoprotective properties of T. macroptera were investigated in different murine models. Administration of T. macroptera ethanolic root and leaf extracts in rats significantly reduced pyrexia, pain, inflammation, and hepatic marker enzymes such as alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase in the different murine models used (p<0.05). A phytochemical screening of T. macroptera revealed the presence of tannins, flavonoids, saponins, anthracene derivatives, sterols, triterpenes, and sugars in both leaf and root extracts as the main phytochemical compounds. This was confirmed by qualitative analysis, liquid chromatography coupled with high-resolution mass spectrometry. T. macroptera extracts demonstrated interesting in vivo antipyretic, analgesic, anti-inflammatory, and hepatoprotective activities. Therefore, T. macroptera should be proposed and further evaluated as a potential improved traditional medicine for the treatment of liver-related disorders and for the relief of pain and fever.

* These authors contributed equally to this work.




Publication History

Received: 07 October 2019
Received: 18 March 2020

Accepted: 19 March 2020

Publication Date:
23 April 2020 (online)

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