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Planta Med 2020; 86(13/14): 941-959
DOI: 10.1055/a-1140-8388
Biological and Pharmacological Activity
Reviews

Prospective Leads from Endophytic Fungi for Anti-Inflammatory Drug Discovery

Pragya Paramita Pal
1   Department of Pharmacy, Birla Institute of Technology and Science–Pilani, Hyderabad Campus, Jawahar Nagar, Hyderabad, Telangana State, India
,
Ameer Basha Shaik
2   Department of Plant Pathology, Professor Jeyashanker Telangana State Agricultural University, Rajendra Nagar, Hyderabad, Telangana State, India
,
A. Sajeli Begum
1   Department of Pharmacy, Birla Institute of Technology and Science–Pilani, Hyderabad Campus, Jawahar Nagar, Hyderabad, Telangana State, India
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Abstract

A wide array of therapeutic effects has been exhibited by compounds isolated from natural sources. “Bio-actives of endophytic origin” is a recently explored area that came into recognition over the last 2 decades. Literature search on the secondary metabolites of endophytes have shown several pharmacologically active compounds especially anti-inflammatory compounds, which have been reviewed in the present paper. The article is structured based on the chemical classification of secondary metabolites. The compounds were identified to possess activity against a total of 16 anti-inflammatory targets. The most common targets involved were NO, TNF-α, and inhibition of total ROS. Further, the article gives a detailed insight into the compounds, their endophytic source, and anti-inflammatory target as well as potency. The contents of the article cover all the scientific reports published until Feb. 2019. Thus 118 compounds and 6 extracts have been reported to be obtained from endophytic sources showing anti-inflammatory activities. Amongst these, herbarin, periconianone A, and periconianone B were identified as the most potent compounds in terms of their IC50 values against NO inhibition.

Key words

endophytes - fungi - anti-inflammation - cytokines - herbarin - periconianone - phytochemicals


Publication History

Received: 02 December 2019

Accepted after revision: 17 March 2020

Article published online:
25 April 2020

© 2020. Thieme. All rights reserved.

Georg Thieme Verlag KG
Stuttgart · New York

 

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