CC BY-NC-ND 4.0 · Geburtshilfe Frauenheilkd 2020; 80(04): 380-390
DOI: 10.1055/a-1134-5951
GebFra Science
Review/Übersicht
Georg Thieme Verlag KG Stuttgart · New York

SARS-CoV-2 Infection in Pregnancy – a Review of the Current Literature and Possible Impact on Maternal and Neonatal Outcome

Article in several languages: English | deutsch
Florian M. Stumpfe
1  Universitätsklinikum Erlangen, Frauenklinik, Erlangen, Germany
,
Adriana Titzmann
1  Universitätsklinikum Erlangen, Frauenklinik, Erlangen, Germany
,
Michael O. Schneider
1  Universitätsklinikum Erlangen, Frauenklinik, Erlangen, Germany
,
Patrick Stelzl
1  Universitätsklinikum Erlangen, Frauenklinik, Erlangen, Germany
,
Sven Kehl
1  Universitätsklinikum Erlangen, Frauenklinik, Erlangen, Germany
,
Peter A. Fasching
1  Universitätsklinikum Erlangen, Frauenklinik, Erlangen, Germany
,
Matthias W. Beckmann
1  Universitätsklinikum Erlangen, Frauenklinik, Erlangen, Germany
,
Armin Ensser
2  Universitätsklinikum Erlangen, Virologisches Institut, Erlangen, Germany
› Author Affiliations
Further Information

Publication History

received 08 March 2020
revised 09 March 2020

accepted 10 March 2020

Publication Date:
26 March 2020 (online)

  

Abstract

In December 2019, cases of pneumonia of unknown cause first started to appear in Wuhan in China; subsequently, a new coronavirus was soon identified as the cause of the illness, now known as Coronavirus Disease 2019 (COVID-19). Since then, infections have been confirmed worldwide in numerous countries, with the number of cases steadily rising. The aim of the present review is to provide an overview of the new severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2) and, in particular, to deduce from it potential risks and complications for pregnant patients. For this purpose, the available literature on cases of infection in pregnancy during the SARS epidemic of 2002/2003, the MERS (Middle East respiratory syndrome) epidemic ongoing since 2012, as well as recent publications on cases infected with SARS-CoV-2 in pregnancy are reviewed and reported. Based on the literature available at the moment, it can be assumed that the clinical course of COVID-19 disease may be complicated by pregnancy which could be associated with a higher mortality rate. It may also be assumed at the moment that transmission from mother to child in utero is unlikely. Breastfeeding is possible once infection has been excluded or the disease declared cured.