Horm Metab Res 2020; 52(04): 207-215
DOI: 10.1055/a-1129-6785
Review
© Georg Thieme Verlag KG Stuttgart · New York

Effect of Bariatric Surgery on the Circulating Level of Adiponectin, Chemerin, Plasminogen Activator Inhibitor-1, Leptin, Resistin, and Visfatin: A Systematic Review and Meta-Analysis

Moein Askarpour
1  Department of Community Nutrition, Tehran University of Medical Sciences, Tehran, Iran
,
Shahab Alizadeh
2  Department of Cellular and Molecular Nutrition, Tehran University of Medical Sciences, Tehran, Iran
,
Amir Hadi
3  Halal Research Center of IRI, FDA, Tehran, Iran
4  Department of Clinical Nutrition, Isfahan University of Medical Sciences, Isfahan, Iran
,
Michael E. Symonds
5  The Early Life Research Unit, Division of Child Health, Obstetrics and Gynaecology, University of Nottingham, Nottingham, UK
,
Maryam Miraghajani
6  Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
,
Ali Sheikhi
1  Department of Community Nutrition, Tehran University of Medical Sciences, Tehran, Iran
,
Ehsan Ghaedi
2  Department of Cellular and Molecular Nutrition, Tehran University of Medical Sciences, Tehran, Iran
7  Students’ Scientific Research Center (SSRC), Tehran University of Medical Sciences (TUMS), Tehran, Iran
› Author Affiliations
Further Information

Publication History

received 29 April 2019

accepted 18 February 2020

Publication Date:
08 April 2020 (online)

Abstract

Different adipokines secreted from adipose tissue, exert a range of physiological effects. The aim of present systematic review and meta-analysis was to critically investigate the consequence of bariatric surgery on circulating adipokines, that is, adiponectin, leptin, visfatin, resistin, plasminogen activator inhibitor, and chemerin. After systematically checking the following electronic databases: ISI web of Science, Scopus and PubMed without limitation in time and language up to February 2019, a pool based on a random effect model was established. Eighty-five eligible studies were entered for quantitative analysis. Our meta-analysis revealed that circulating adiponectin increased significantly after bariatric surgery [Standardized mean difference (SMD)=1.401, 95% CI: 1.101, 1.701, p<0.001]; whilst leptin (SMD=–2.178, 95% CI: –2.433, –1.923, p<0.001), PAI-1 (–14.928 ng/ml 95% CI: –21.794, –8.063, p<0.001), and chemerin (–50.238 ng/ml 95% CI: –85.708, –14.768, p<0.001) decreased. However, serum visfatin (2.05 ng/ml, 95% CI: –5.07, 9.17, p=0.573) and resistin (–2.080 ng/ml, 95% CI: –5.352, 1.192, p=0.21) were unchanged. In conclusion, bariatric surgery is associated with a reduction in specific adipokines including leptin, chemerin, and PAI-1, whereas adiponectin is raised, adaptations that could be indicative of improved fat mass and function.

Supplementary Material