Int J Sports Med 2020; 41(08): 495-504
DOI: 10.1055/a-1128-7128

Musculoskeletal Regeneration, Rehabilitation, and Plasticity Following Traumatic Injury

1  School of Kinesiology, University of Minnesota, Minneapolis, United States
Benjamin T. Corona
2  School of Medicine, Wake Forest University, Winston-Salem, United States
Jarrod A. Call
3  Department of Kinesiology, University of Georgia, Athens, United States
4  Regenerative Bioscience Center, University of Georgia, Athens, United States
› Author Affiliations
Funding: The Assistant Secretary of Defense for Health Affairs endorsed by the Department of Defense, through the Clinical & Rehabilitative Medicine Research Program, FY17 Neuromusculoskeletal Injuries Rehabilitation Research Award (W81XWH-18–1–0710 to SMG and JAC). Opinions, interpretations, conclusions and recommendations are those of the authors and are not necessarily endorsed by the Department of Defense or National Institutes of Health.


The musculoskeletal system has an integral role throughout life, including structural support to the body, protection, and allowing a range of fine to complex movements for daily living to elite sporting events. At various times, injuries to the musculoskeletal system occur resulting in varying levels of impact to the person both acutely and chronically. Specifically, there is a spectrum of complexity in orthopedic injuries, with some such as common muscle strains, that while burdensome will have no impact on life-long functional ability, and others that can result in long lasting disability. Focusing on extremity injuries, this review highlights: i)the current impact of orthopedic injuries in sport and daily life; ii) the foundation of bone and skeletal muscle repair and regeneration; and iii) the disruptions in regenerative healing due to traumatic orthopedic injuries. This review seeks to maximize the broad and collective research impact on sport and traumatic orthopedic injuries in search of promoting ongoing innovation for treatment and rehabilitation approaches aimed to improve musculoskeletal health throughout life.

Publication History

Received: 00 00 2020

Accepted: 12 February 2020

Publication Date:
02 April 2020 (online)

© Georg Thieme Verlag KG
Stuttgart · New York