CC BY-NC-ND 4.0 · Endosc Int Open 2020; 08(05): E607-E610
DOI: 10.1055/a-1127-2991
Innovation forum

First-in-man feasibility study of a novel ingestible magnetically inflated balloon capsule for treatment of obesity

Hung Leng Kaan
1  Department of General Surgery, National University Hospital, Singapore
,
Phuoc Thien Phan
2  School of Mechanical & Aerospace Engineering, Nanyang Technological University, Singapore
,
Anthony Meng Huat Tiong
2  School of Mechanical & Aerospace Engineering, Nanyang Technological University, Singapore
,
Muneaki Miyasaka
2  School of Mechanical & Aerospace Engineering, Nanyang Technological University, Singapore
,
Soo Jay Phee
2  School of Mechanical & Aerospace Engineering, Nanyang Technological University, Singapore
,
Khek Yu Ho
3  Department of Medicine, National University of Singapore
› Author Affiliations
  

Abstract

Intragastric balloons (IGBs) are an established treatment option for obesity. Major barriers to dissemination of IGBs include lack of long-term efficacy outcomes, safety concerns, cost, and tolerability. We developed a novel ingestible magnetically inflated balloon capsule (IMI-BC) in hopes of overcoming these challenges. The IMI-BC is significantly cheaper than IGBs currently available on the market. We performed proof-of-concept animal studies and a first-in-human feasibility study to demonstrate the feasibility of inflating the IMI-BC using an external magnet. Further studies are currently being conducted to evaluate the safety, tolerability, and long-term efficacy of the IMI-BC. When fully developed, we anticipate that this device will benefit obese patients.



Publication History

Received: 19 June 2019

Accepted: 30 December 2019

Publication Date:
17 April 2020 (online)

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