CC BY-NC-ND 4.0 · Geburtshilfe Frauenheilkd 2020; 80(11): 1093-1104
DOI: 10.1055/a-1124-7225
GebFra Science

Liquid Biopsy in Breast Cancer

Article in several languages: English | deutsch
Maggie Banys-Paluchowski
1  Frauenklinik, Asklepios Klinik Barmbek, Hamburg, Germany
Natalia Krawczyk
2  Universitäts-Frauenklinik, Universitätsklinikum Düsseldorf, Düsseldorf, Germany
Tanja Fehm
2  Universitäts-Frauenklinik, Universitätsklinikum Düsseldorf, Düsseldorf, Germany
› Author Affiliations


In recent years, the blood-based analysis of circulating tumour cells (CTCs) and nucleic acids (DNA/RNA), otherwise known as liquid biopsy, has become increasingly important in breast cancer. Numerous trials have already underscored the high prognostic significance of CTC detection in both early and metastatic stages. Moreover, the changes in CTC levels and circulating tumour DNA (ctDNA) during the course of the disease correlate with the response to treatment. Research currently focuses on liquid-biopsy based therapeutic interventions in metastatic breast cancer. In this context, alpelisib, a PI3K inhibitor, was the first agent to be approved by FDA and EMA.

Publication History

Received: 29 June 2020

Accepted after revision: 02 August 2020

Publication Date:
06 November 2020 (online)

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