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CC BY-NC-ND 4.0 · Horm Metab Res 2020; 52(06): 379-385
DOI: 10.1055/a-1120-8647
Review

Angiotensin II Type 1 Receptor Autoantibodies in Primary Aldosteronism

Authors

  • Lucie S. Meyer

    1   Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU München, Germany

  • Siyuan Gong

    1   Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU München, Germany

  • Martin Reincke

    1   Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU München, Germany

  • Tracy Ann Williams

    1   Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU München, Germany
    2   Division of Internal Medicine and Hypertension, Department of Medical Sciences, University of Turin, Turin, Italy

Funding: M. Reincke is supported by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No. 694913). T. A. Williams and M. Reincke are supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) Projektnummer: 314061271-TRR 205.
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Abstract

Primary aldosteronism (PA) is the most common form of endocrine hypertension. Agonistic autoantibodies against the angiotensin II type 1 receptor (AT1R-Abs) have been described in transplantation medicine and women with pre-eclampsia and more recently in patients with PA. Any functional role of AT1R-Abs in either of the two main subtypes of PA (aldosterone-producing adenoma or bilateral adrenal hyperplasia) requires clarification. In this review, we discuss the studies performed to date on AT1R-Abs in PA.

Key words

primary aldosteronism - angiotensin II receptor - autoantibodies - endocrine hypertension - adrenal cortex


Publication History

Received: 02 January 2020

Accepted: 12 February 2020

Article published online:
13 March 2020

© 2020. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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