CC BY-NC-ND 4.0 · Geburtshilfe Frauenheilkd 2020; 80(03): 277-287
DOI: 10.1055/a-1111-2431
GebFra Science
Review/Übersicht
Georg Thieme Verlag KG Stuttgart · New York

Update Breast Cancer 2020 Part 1 – Early Breast Cancer: Consolidation of Knowledge About Known Therapies

Article in several languages: English | deutsch
Andreas Schneeweiss
1  National Center for Tumor Diseases, Division Gynecologic Oncology, University Hospital and German Cancer Research Center, Heidelberg, Germany
,
Andreas D. Hartkopf
2  Department of Obstetrics and Gynecology, University of Tübingen, Tübingen, Germany
,
Volkmar Müller
3  Department of Gynecology, Hamburg-Eppendorf University Medical Center, Hamburg, Germany
,
Achim Wöckel
4  Department of Gynecology and Obstetrics, University Hospital Würzburg, Würzburg, Germany
,
Michael P. Lux
5  Klinik für Gynäkologie und Geburtshilfe, Frauenklinik St. Louise, Paderborn, St. Josefs-Krankenhaus, Salzkotten, Germany
,
Wolfgang Janni
6  Department of Gynecology and Obstetrics, Ulm University Hospital, Ulm, Germany
,
Johannes Ettl
7  Department of Obstetrics and Gynecology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
,
Erik Belleville
8  ClinSol GmbH & Co KG, Würzburg, Germany
,
Jens Huober
6  Department of Gynecology and Obstetrics, Ulm University Hospital, Ulm, Germany
,
Marc Thill
10  Agaplesion Markus Krankenhaus, Frauenklinik, Frankfurt, Germany
,
Peter A. Fasching
11  Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany
,
Hans-Christian Kolberg
12  Department of Gynecology and Obstetrics, Marienhospital Bottrop, Bottrop, Germany
,
Patrik Pöschke
11  Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany
,
Manfred Welslau
13  Onkologie Aschaffenburg, Aschaffenburg, Germany
,
Friedrich Overkamp
14  OncoConsult Overkamp GmbH, Berlin, Germany
,
Hans Tesch
15  Oncology Practice at Bethanien Hospital Frankfurt, Frankfurt, Germany
,
Tanja N. Fehm
16  Department of Gynecology and Obstetrics, University Hospital Düsseldorf, Düsseldorf, Germany
,
Diana Lüftner
17  Charité University Hospital, Campus Benjamin Franklin, Department of Hematology, Oncology and Tumour Immunology, Berlin, Germany
,
Florian Schütz
9  Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany
› Author Affiliations
Further Information

Publication History

received 27 January 2020
revised 03 February 2020

accepted 03 February 2020

Publication Date:
04 March 2020 (online)

  

Abstract

This review is intended to present the latest developments in the prevention and treatment of early breast cancer. The risk of breast cancer can be increasingly better characterised with large epidemiological studies on genetic and non-genetic risk factors. Through new analyses, the evidence for high-penetrance genes as well as for low-penetrance genes was able to be improved. New data on denosumab and atezolizumab are available in the neoadjuvant situation as is a pooled appraisal of numerous studies on capecitabine in the curative situation. There is also an update to the overall survival data of pertuzumab in the adjuvant situation with a longer follow-up observation period. Finally, digital medicine is steadily finding its way into science. A recently conducted study on automated breast cancer detection using artificial intelligence establishes the basis for a future review in clinical studies.