A Case of Unresectable Pancreatic Cancer with Long-Term Survival in High-Intensity Focused Ultrasound (HIFU) Therapy

Introduction

Despite advancements in imaging diagnosis, about 60% of cases of pancreatic cancer (PC) are still unresectable. Chemotherapy and radiochemotherapy are commonly performed as alternative treatments, but satisfaction with the results remains low. High intensity focused ultrasound therapy (HIFU) is expected to be a minimally invasive therapy for these cases. HIFU is an epoch-making therapeutic method and is a local therapy that converges a large number of ultrasonic transmission sources at one point at the target site of the tumor and cauterizes tissues from outside the body [1] [2] [3].

Case Description

A 63-year-old male, who underwent CT examination at another medical center due to epigastric pain, was then diagnosed with a low-density tumor (65mm) infiltrating the celiac artery (CA) and superior mesenteric artery (SMA) in the pancreas body ([Fig. 1a]). It was histologically diagnosed as PC (UICC criteria; stage III) by EUS-FNA. There was no suitable surgery. Therefore, chemoradiotherapy was initiated due to locally advanced PC. Chemotherapy was performed with GS therapy (GEM 1000 mg/m²+S-1 100 mg/day), and radiotherapy with 50.4 Gy / 28 fraction. After receiving GS therapy (GEM 1000 mg/m²+S-1 100 mg/day) for 2 months, the PC was still diagnosed as progressive disease (PD) based on WHO criteria by CT. The patient presented at our hospital for HIFU therapy. Under sufficient informed consent, HIFU therapy was performed as an additive therapy to systemic chemotherapy. This clinical trial was approved by the ethics committee of our hospital (IRB: 890) and registered with University Hospital Medical Information (UMIN) and was initiated (UMIN000009969). B-mode US showed a hypoechoic mass in the pancreas body ([Fig. 2a]), and contrast-enhanced ultrasound (CE-US) showed isovascularity in previous HIFU therapy ([Fig. 2b]). The FEP-BY 02 HIFU Therapeutic System was used as the HIFU device. (Yuande Bio-Medical Engineering, Beijing, China) ([Fig. 3]).

Fig. 1 CT imaging: a: CT before HIFU therapy showed a low-density mass (65 mm) infiltrating the CA and SMA in the pancreas body. b: CT imaging 3 months after HIFU therapy showed that the pancreas tumor had shrunk slightly. c: CT imaging after the second HIFU therapy (5 months after the first HIFU therapy) showed that the tumor had shrunk and PR in the therapeutic effect was obtained. d: CT imaging after the 4th HIFU therapy (19 months after the first HIFU therapy) showed the tumor size was unchanged (PR continued). e: CT imaging after the 7th HIFU therapy (39 months after the first HIFU therapy) showed continued PR until the patient passed away.

Fig. 2 US imaging: a: B-mode US before HIFU therapy showed a hypoechoic mass (65 mm) in the pancreas body. b: CE-US before HIFU therapy showed an isovascular mass in the pancreas body. c: B-mode US after HIFU therapy showed echogenic change in the tumor post-HIFU therapy. d: CE-US after HIFU therapy showed a change in vascularity from isovascularity to hypovascularity

Fig. 3 FEP-BY Series HIFU Therapy System: The system includes computer control, GE ultrasound imaging system, and treatment table with dual transducers.

After fasting for 12 h before therapy, the patient was placed in a supine position and observed with B-mode ultrasound in order to determine the appropriate therapeutic route and the relation with surrounding organs before therapy. Low-concentration ultrasonic gel for HIFU was applied to the therapeutic area, deaerated water was placed in the water sac, the transducer was lowered to the therapeutic area, and the target was observed with the image confirmation probe while slight compression was applied with the water sac. The image confirmation probe and the therapeutic oscillator were set on the same axis and a therapeutic plan was formulated while watching the target. The thickness of the abdominal wall (skin, subcutaneous fat and muscles of the abdominal wall), the distance from the skin to the target, and the size and depth of the tumor were measured. The therapeutic dose was then calculated considering the attenuation due to the tissue and surrounding environment. The therapeutic plan, output power and HIFU therapy position were entered into the computer. The range cauterized by one irradiation was as small as 3× 3×10 mm. Therapy was carried out while confirming the US image in real time while moving 3 mm vertically and 3 mm to the left and right. During the operation, no significant pain was registered. Therapy was set as one set of 2–3 treatments every 3 days, with the treatment time averaging 30 min. The target HIFU irradiation was 1 000 per dose.

The clinical course is shown in [Fig. 4]. The tumor showed echogenic change immediately after HIFU therapy on B-mode US ([Fig. 2c]) and a hypovascularity change on CE-US ([Fig. 2d]). The CT image taken after 3 months of HIFU therapy also showed that the tumor had shrunk ([Fig. 1b]). As for symptoms, the amount of pain had been significantly reduced. Therefore, the amount of opioid prescribed was also reduced. Additional HIFU therapy (2nd) was administered in order to obtain further therapeutic results. As seen on the CT image taken 5 months after the first therapy, the tumor was further reduced and PR as the therapeutic effect was also obtained ([Fig.1c]). Because of increased pain, additional HIFU therapy (3rd treatment) was administered. On the CT image taken 19 months after the first HIFU treatment, the tumor marker was elevated and epigastric discomfort had increased. Since the tumor size was unchanged, stable disease (SD) ([Fig.1d]), additional HIFU therapy (4th therapy) was performed. As seen on the CT image taken 26 months after the first HIFU therapy, the tumor size was unchanged and the patient’s pain had improved. However, tumor marker elevation was observed, and an additional HIFU therapy (5^th therapy) was performed. Even after that, no marked change was noted in the tumor size on the image. However, since the tumor marker temporarily decreased and then increased again, two additional HIFU treatments were performed (34 and 39 months after the first HIFU therapy). Regarding chemotherapy, GS therapy also continued until the 6th HIFU therapy and then changed to GEM + nab-PTX therapy 3 years and 6 months after the introduction of chemotherapy. However, although there was no change on the image ([Fig. 1e]), the general conditions, such as the appearance of edema, had worsened and the malaise had increased. Ultimately, the patient died 4 years and 6 months after the onset of PC and 3 years and 6 months after the start of HIFU therapy after being diagnosed with PD.

Fig. 4 Clinical course; each treatment, tumor size, tumor marker (CEA label), anti-tumor effect, pain relief control were showed in the monthly time series as the clinical course.

• References

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