Traumaassoziierte Koagulopathie: Pathophysiologie und Therapie

Zusammenfassung

Die anhaltende unkontrollierte Blutung ist eine der führenden Todesursachen bei polytraumatisierten Patienten [1], [2], [3], [4], [5]. Hypoperfusion durch große Blutverluste führt zu Gewebeschäden, generalisierter Immunantwort sowie Aktivierung des Gerinnungssystems und damit zu einer traumaassoziierten Koagulopathie (TAK) [4], [5]. Durch eine adäquate, frühzeitige Behandlung der TAK können Morbidität und Mortalität signifikant reduziert werden.

Abstract

Persistent, uncontrolled bleeding after trauma is one of the leading causes of fatalities in patients with severe injuries. 40% of trauma deaths are associated with massive haemorrhage. Hypoperfusion due to major loss of blood volume leads to tissue damage. In combination with acidosis and hypothermia, a generalized immune response with activation of coagulation is triggered. This leads to trauma-induced coagulopathy. A suitable, early treatment might lead to a significant reduction in morbidity and mortality.

Schlüsselwörter

traumaassoziierte Koagulopathie - Point of Care - Plasma - Faktorenkonzentrate - Schockraum

Key words

trauma-induced coagulopathy - point of care - plasma - coagulation factor concentrates - emergency room management

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