Abstract
Background Exercise benefits people with
abnormal glucose metabolism, and serum ficolin-3
levels have been reported to be associated with
diabetes. However, no relevant study has discussed
the relationship between high-intensity interval
training (HIIT) and ficolin-3 in a Chinese
population.
Objective To compare the effect of HIIT and
moderate-intensity continuous training (MICT) on
blood pressure, glucose control, the lipid profile
and the serum ficolin-3 level in patients with
prediabetes and type 2 diabetes (T2D).
Methods We recruited 145 patients with
prediabetes and 196 T2D patients from March to
June 2018. All participants were randomly grouped
into HIIT and MICT groups. HIIT consisted of
progressing to twelve 1-min bouts at 90% maximal
aerobic capacity (1 min recovery), and MICT
consisted of progressing to 20 min at 65% maximal
aerobic capacity. ˙VO2 peak, body
composition, blood pressure, glucose, the lipid
profile and the serum ficolin-3 level were
measured before and after three weeks of
training.
Results After 3 weeks of training,
participants in both the HIIT and MICT groups had
significantly lower SBP, BMI, waist circumference,
% body fat, and serum levels of FPG, TC, TGs, UA
and ficolin-3, as well as increased vital capacity
and VOmax. Additionally, the patients in the HIIT
group still had significantly lower levels of 2hPG
and LDL-C, regardless of prediabetes or diabetes
status. After comparing the differences in the
variation in parameters between the HIIT and MICT
groups, we found that HIIT could help patients
with prediabetes or diabetes acquire better
effects of treatment in regard to anthropometry,
blood pressure, glucose control, UA and ficolin-3
levels than MICT. Finally, the patients in the
HIIT group had a lower rate of loss to follow-up
and a higher rate of session attendance.
Conclusions Both HIIT and MICT were
beneficial exercise strategies for health in
patients with prediabetes or T2D. However, HIIT is
a more time-efficient strategy and could lower the
serum level of ficolin-3 in patients after 3 weeks
of training.
Key words HIIT - MICT - ficolin-3 - prediabetes - type 2 diabetes
