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Exp Clin Endocrinol Diabetes 2021; 129(04): 314-321
DOI: 10.1055/a-1023-6710
Article

Hyperuricemia Inhibition Protects SD Rats Against Fructose-Induced Obesity Hypertension Via Modulation of Inflammation and Renin-Angiotensin System in Adipose Tissue

Jun Xia Zhang
1   Department of Endocrinology, Central Theater Command General Hospital of the Chinese PLA, Wuhan, China
,
Xue Lin
1   Department of Endocrinology, Central Theater Command General Hospital of the Chinese PLA, Wuhan, China
,
Jinxiu Xu
1   Department of Endocrinology, Central Theater Command General Hospital of the Chinese PLA, Wuhan, China
,
Feng Tang
1   Department of Endocrinology, Central Theater Command General Hospital of the Chinese PLA, Wuhan, China
› Author Affiliations Funding: This work was supported by the National Natural Science Foundation of China (NSFC Number 81500654); Hubei Province health and family planning scientific research project (Number WJ2018H0062); and the Bethune-Merck Diabetes Research Foundation (Number G2018030).
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Abstract

Objective The present study was aimed to reveal the relationship between uric acid and fructose-induced obesity hypertension and its mechanisms.

Methods A rat model with obesity hypertension was induced by a high-fructose diet. In the experiment I, the rats were fed with fructose for 8 wks along with allopurinol or benzbromarone at the beginning. In the experiment II, the rats were fed with fructose for 8 wks firstly. And then, these rats were treated with allopurinol or benzbromarone for additional 6 wks.

Results Fructose-fed rats showed hyperuricemia, abdominal obesity hypertension and an activation in adipose renin-angiotensin system (RAS). Also, fructose-fed rats had higher levels of proinflammatory cytokines and more macrophages infiltrating in adipose tissue. In the experiment I, allopurinol and benzbromarone significantly reduced serum uric acid at 8 wk. Adipose RAS overactivation, adipose inflammatory responses and the development of obesity hypertension were all effectively prevented by hyperuricemia inhibition. In the experiment II, 6-wk treatment with allopurinol and benzbromarone significantly decreased serum uric acid, downregulated adipose RAS, abolished adipose inflammation and improved obesity hypertension.

Conclusion In conclusion, urate-lowering therapy protects rats against fructose-induced obesity hypertension. The mechanisms appear to be via downregulated adipose RAS and reduced inflammation in adipose tissue.

Key words:

uric acid - fructose - adipose tissue - renin-angiotensin system - obesity hypertension


Publication History

Received: 23 June 2019
Received: 16 September 2019

Accepted: 08 October 2019

Article published online:
04 November 2019

© 2019. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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