Horm Metab Res 2019; 51(11): 709-713
DOI: 10.1055/a-1020-3992
Endocrine Care
© Georg Thieme Verlag KG Stuttgart · New York

Markers of Metabolic Syndrome in Patients with Pituitary Adenoma: A Case Series of 303 Patients

Seher Çetinkaya Altuntaş
1   Department of Internal Medicine, Division of Endocrinology, Recep Tayyip Erdogan University, Recep Tayyip Erdogan Universitesi, Rize, Turkey
,
Mehtap Evran
2   Medical Faculty, Department of Internal Medicine, Division of Endocrinology, Cukurova University, Adana, Turkey
,
Murat Sert
2   Medical Faculty, Department of Internal Medicine, Division of Endocrinology, Cukurova University, Adana, Turkey
,
Tamer Tetiker
2   Medical Faculty, Department of Internal Medicine, Division of Endocrinology, Cukurova University, Adana, Turkey
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Publikationsverlauf

received 12. April 2019

Publikationsdatum:
04. November 2019 (online)

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Abstract

To assess the demographic characteristics and hormonal status of patients who presented to our clinic with pituitary adenoma and to demonstrate the presence, prevalence, and relationship of metabolic syndrome parameters in these patients. The study included 303 patients with known or newly diagnosed pituitary adenoma and 52 age- and sex-matched healthy controls. The patients were classified into 3 groups; acromegaly (ACRO) (n=54),prolactinoma (PRLoma) (n=163), and non-functional adenoma (NFA) (n=86). in 55.6% (n=172) and 52% (n=163) of the patients, respectively. The waist circumference of all patients (p<0.001) and body mass index (BMI) of patients with PRLoma (p=0.03) and ACRO (p<0.001) were found to be significantly higher than in the controls. The HbA1c, insulin and HOMA-IR values were significantly higher in the ACRO and PRLoma groups, whereas the insulin and HOMA-IR values were significantly higher in the NFA group compared with the control group (p<0.001 and p<0.001, respectively). When the 3 patient groups were compared, waist circumference and BMI were significantly higher in the ACRO group than in the PRLoma group (p=0.04 and p=0.03, respectively). In patients developing pituitary failure after treatment, age, waist circumference, plasma glucose, low-density lipoproteins and triglyceride values were significantly increased when compared with those without pituitary failure after treatment (p<0.001). In our study, it was found that there was increased metabolic and cardiovascular risk in functional pituitary adenoma and NFA.