Clinical Impact of the TCF7L2 Gene rs7903146 Type 2 Diabetes
                    Mellitus Risk Polymorphism in Women with Gestational Diabetes Mellitus: Impaired
                    Glycemic Control and Increased Need of Insulin Therapy

Laura Potasso; Nikolaos Perakakis; Apostolia Lamprinou; Elektra Polyzou; Dimitrios Kassanos; Andreas Peter; Günter Päth; Jochen Seufert; Katharina Laubner

doi:10.1055/a-1008-9223

Experimental and Clinical Endocrinology & Diabetes, Table of Contents

Exp Clin Endocrinol Diabetes 2020; 128(10): 663-666
DOI: 10.1055/a-1008-9223

Article

Clinical Impact of the TCF7L2 Gene rs7903146 Type 2 Diabetes Mellitus Risk Polymorphism in Women with Gestational Diabetes Mellitus: Impaired Glycemic Control and Increased Need of Insulin Therapy

Laura Potasso‡

¹Division of Endocrinology and Diabetology, Department of Medicine II, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany

,

Nikolaos Perakakis‡

¹Division of Endocrinology and Diabetology, Department of Medicine II, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany

²Current address: Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts

,

Apostolia Lamprinou

³Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, University Hospital Tübingen, Tübingen, Freiburg, Germany

⁴Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen, Tübingen, Germany

⁵German Center for Diabetes Research (DZD), Neuherberg, Freiburg, Germany

,

Elektra Polyzou

⁶University Hospital Attikon, 3rd Department of Obstetrics and Gynecology, Greece

,

Dimitrios Kassanos

⁶University Hospital Attikon, 3rd Department of Obstetrics and Gynecology, Greece

,

Andreas Peter

³Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, University Hospital Tübingen, Tübingen, Freiburg, Germany

⁴Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen, Tübingen, Germany

⁵German Center for Diabetes Research (DZD), Neuherberg, Freiburg, Germany

,

Günter Päth

¹Division of Endocrinology and Diabetology, Department of Medicine II, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany

,

Jochen Seufert

¹Division of Endocrinology and Diabetology, Department of Medicine II, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany

,

Katharina Laubner

¹Division of Endocrinology and Diabetology, Department of Medicine II, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany

› Author Affiliations

Abstract

Background The single nucleotide polymorphism in TCF7L2 rs7903146 is associated with an increased risk of type 2 diabetes mellitus and gestational diabetes mellitus. Mechanisms by which this mutation acts, and its impact on the clinical course of the diseases remain unclear. Here we investigated the clinical impact of the T risk allele in women with gestational diabetes mellitus.

Methods We genotyped the C/T polymorphism in 164 Caucasian women with GDM (German n=114; Greek n=50). The impact of the T allele on the results of the 75g oral-glucose-tolerance-test, and on the required therapy (diet/lifestyle or insulin) was investigated.

Results During oral-glucose-tolerance-test, women harboring the T allele displayed significantly higher glucose values at 60 min (p=0.034) and were more likely to require insulin therapy even after adjusting for confounders, such as BMI and age.

Conclusion These results provide evidence that the T risk allele in TCF7L2 rs7903146 is associated with failure in early postprandial glycemic control and requirement of insulin therapy in women with gestational diabetes mellitus, even after adjusting for confounding factors such BMI and age.

key words

gestational diabetes mellitus - TCF7L2 - insulin therapy

Full Text

References

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