Antinociceptive and Anti-Inflammatory Effects of Bixin, a Carotenoid Extracted from the Seeds of Bixa orellana

Samanta Daliana Golin Pacheco; Alexia Thamara Gasparin; Carlos Henrique Alves Jesus; Bruna Bittencourt Sotomaior; Ana Clara Sans Salomão Brunow Ventura; Daiany Darlly Belo Redivo; Daniela de Almeida Cabrini; Josiane de Fátima Gaspari Dias; Marilis Dallarmi Miguel; Obdulio Gomes Miguel; Joice Maria da Cunha

doi:10.1055/a-1008-1238

Planta Medica, Inhaltsverzeichnis

Planta Med 2019; 85(16): 1216-1224
DOI: 10.1055/a-1008-1238

Biological and Pharmacological Activity

Original Papers

Georg Thieme Verlag KG Stuttgart · New York

Antinociceptive and Anti-Inflammatory Effects of Bixin, a Carotenoid Extracted from the Seeds of Bixa orellana

Samanta Daliana Golin Pacheco‡

¹Postgraduate Program in Pharmaceutical Sciences, Federal University of Paraná, Curitiba, Parana, Brazil

,

Alexia Thamara Gasparin‡

²Laboratory of Pharmacology of Pain, Department of Pharmacology, Federal University of Paraná, Curitiba, Parana, Brazil

,

Carlos Henrique Alves Jesus

²Laboratory of Pharmacology of Pain, Department of Pharmacology, Federal University of Paraná, Curitiba, Parana, Brazil

,

Bruna Bittencourt Sotomaior

²Laboratory of Pharmacology of Pain, Department of Pharmacology, Federal University of Paraná, Curitiba, Parana, Brazil

,

Ana Clara Sans Salomão Brunow Ventura

²Laboratory of Pharmacology of Pain, Department of Pharmacology, Federal University of Paraná, Curitiba, Parana, Brazil

,

Daiany Darlly Belo Redivo

²Laboratory of Pharmacology of Pain, Department of Pharmacology, Federal University of Paraná, Curitiba, Parana, Brazil

,

Daniela de Almeida Cabrini

²Laboratory of Pharmacology of Pain, Department of Pharmacology, Federal University of Paraná, Curitiba, Parana, Brazil

,

Josiane de Fátima Gaspari Dias

¹Postgraduate Program in Pharmaceutical Sciences, Federal University of Paraná, Curitiba, Parana, Brazil

,

Marilis Dallarmi Miguel

¹Postgraduate Program in Pharmaceutical Sciences, Federal University of Paraná, Curitiba, Parana, Brazil

,

Obdulio Gomes Miguel

¹Postgraduate Program in Pharmaceutical Sciences, Federal University of Paraná, Curitiba, Parana, Brazil

,

Joice Maria da Cunha

²Laboratory of Pharmacology of Pain, Department of Pharmacology, Federal University of Paraná, Curitiba, Parana, Brazil

› Institutsangaben

Abstract

Bixin is the main natural apocarotenoid extracted from the seeds of Bixa orellana, widely used as a cosmetic and textile colorant. Despite the description of several pharmacological properties of B. orellana extracts, little has been studied regarding the pharmacological properties of bixin. Then we aimed to investigate the potential anti-inflammatory and antinociceptive effect of bixin in preclinical models of inflammation and acute pain. The anti-inflammatory activity of bixin (15 or 30 mg/kg, orally) was determined using carrageenan-induced paw edema and the myeloperoxidase (MPO) activity in male Wistar rats. The antinociceptive effect of bixin was assessed in the formalin and hot plate tests in rats (at same doses) and in the acetic acid-induced writhing test in Swiss albino male mice (at doses of 27 or 53 mg/kg). General locomotor activity was evaluated in the open field test. Only the higher dose of bixin significantly decreased the carrageenan-induced paw edema and the MPO activity and increased the latency time in the hot plate. Both doses of bixin significantly reduced the number of flinches in both phases of the formalin test and the number of acetic acid-induced writhings without changing the locomotor performance in the open field test. This study validates the use of bixin as an anti-inflammatory trough mechanism related to the reduction of neutrophil migration. Furthermore, this is the first report showing the antinociceptive property of bixin, which does not appear to be related to the sedative effect. Further studies are necessary to characterize the mechanisms involved in these effects.

Key words

Bixa orellana - Bixaceae - inflammation - nociception - myeloperoxidase - carrageenan

Volltext

Referenzen

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