Drug Research, Table of Contents Drug Res (Stuttg) 2019; 69(S 01): S7-S8DOI: 10.1055/a-0982-5043 Symposium der Paul-Martini-Stiftung Georg Thieme Verlag KG Stuttgart · New YorkDoes Everything Get Slower with Age? Pharmacokinetics in the Elderly Joachim Höchel Recommend Article Abstract Full Text References References 1 Turnheim K. When drug therapy gets old: pharmacokinetics and pharmacodynamics in the elderly. Exp Gerontol 2003; 38: 843-853 2 Klotz U. Pharmacokinetics and drug metabolism in the elderly. Drug Metab Rev 2009; 41: 67-76 3 Nation RL, Vine J, Triggs EJ. et al. Plasma level of chlormethiazole and two metabolites after oral administration to young and aged human subjects. Eur J Clin Pharmacol 1977; 12: 137-145 4 Castleden CM, George CF. The effect of ageing on the hepatic clearance of propranolol. Br J Clin Pharmacol 1979; 7: 49-54 5 Perrie Y, Badhan RKS, Kirby DJ. et al. The impact of ageing on the barriers to drug delivery. J Control Release 2012; 161: 389-398 6 Pea F. Pharmacokinetics and drug metabolism of antibiotics in the elderly. Expert Opin Drug Metab Toxicol 2018; 14: 1087-1100 7 Sotaniemi EA, Arranto AJ, Pelkonen O. et al. Age and cytochrome P450-linked drug metabolism in humans: An analysis of 226 subjects with equal histopathologic conditions. Clin Pharmacol Ther 1997; 61: 331-339 8 Cotreau MM, von Moltke LL, Greenblatt DJ. The influence of age and sex on the clearance of cytochrome P450 3A substrates. Clin Pharmacokinet 2005; 44: 33-60 9 Fliser D, Franek E, Joest M. et al. Renal function in the elderly: impact of hypertension and cardiac function. Kidney Int 1997; 51: 1196-1204 10 Björkman IK, Fastbom J, Schmidt IK. et al. Drug-drug interactions in the elderly. Ann Pharmacother 2002; 36: 1675-1681