DOI: 10.1055/a-0972-0788
Empfehlungen zur systemischen Therapie des metastasierten Nierenzellkarzinoms 2019
Current recommendations for the systemic treatment of metastatic renal cell carcinomaPublication History
Publication Date:
04 September 2019 (online)
Zusammenfassung
Für die Behandlung des metastasierten Nierenzellkarzinoms steht eine Vielzahl an Medikamenten für die Systemtherapie zur Verfügung. Diese werden sowohl in der Erst- als auch Zweitlinientherapie und in späteren Linien eingesetzt. Die vorliegende Übersichtsarbeit beschreibt die in Deutschland zugelassenen Medikamente der Tyrosinkinase-, mTOR- und Immuncheckpointinhibition für die Systemtherapie des metastasierten klarzelligen Nierenzellkarzinoms und gibt eine Empfehlung für deren klinischen Einsatz aufgrund der vorhanden Phase II- und Phase III-Studiendaten. Des Weiteren werden detailliert die potenziellen Nebenwirkungen der einzelnen Substanzen beschrieben.
Abstract
Numerous substances are available for the treatment of metastatic renal cell carcinoma (mRCC). Therefore, medical treatment of patients with mRCC has become a very complex subject. This review summarises clinical studies and typical side-effects of currently available agents that have been approved in Germany. The authors give suggestions for the use of these substances in the different therapy lines.
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