Abstract
Background Ischemia-reperfusion (I-R) leads to acute kidney injury (AKI). The present study
investigated the effects of nitroglycerine (NG) on improving renal dysfunctions caused
by I-R in rats.
Methodology Twenty-four rats were equally divided into four groups: (1) the control group, (2)
the sham group, (3) the I-R group, and (4) NG-treated groups.NG (50 μg/kg) was injected
intraperitoneally after induction of IR. I-R was induced through clamping of the bilateral
renal artery and vein of both kidneys for 20 min followed by 24 h of reperfusion.
Results NG significantly increased the creatinine clearance levels and renal blood flow
rate (which was reduced by I-R). NG also significantly improved serum electrolytes
(sodium and potassium) that were disordered by I-R. In addition, NG significantly
offset impaired antioxidant defense mechanism and inhibited lipid peroxidation.
Conclusions The results show NG has a protective effect on renal tissue against AKI caused by
I-R. These protective effects mediated through antioxidant activity and decrease of
lipid peroxidation.
Key words
nitroglycerine - renal ischemia-reperfusion injury - rat
